About: Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples

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About: Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples Goto Sponge NotDistinct Permalink

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scientific article published on 31 May 2011

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 2011 (uk) scientific article published on 31 May 2011 (en) artículu científicu espublizáu en mayu de 2011 (ast)
publication date	wds:Q84230049-15A01E1E-E0CA-4C12-889F-F7C2BB123F7E
publication date	2011-05-31 00:00:00Z (xsd:dateTime)
exact match	wds:Q84230049-E6721C59-A6E1-414B-B028-F8686FFDEC9C
exact match	https://scigraph.springernature.com/pub.10.1007/s10637-011-9695-4
cites work	wds:Q84230049-0232ACC3-7D08-43F4-B577-A6CDD1CC680B wds:Q84230049-065B48CA-02D4-4C01-95E0-85355C783E15 wds:Q84230049-0950F489-8C70-49FE-807F-B30E4A721559 wds:Q84230049-188A124B-8AF3-4C9F-809C-FFD314667068 wds:Q84230049-26D81A41-DDA9-4F55-8A86-1E5EC3482D82 wds:Q84230049-28D9750F-6E53-4567-819C-6F8EE5E949DA wds:Q84230049-32BF0BBC-AC64-42B9-A57F-087DEAD02B95 wds:Q84230049-400DE5F3-0956-45C5-8B19-BACAA90DDC3F wds:Q84230049-4975D5CE-76A9-49AB-ABD0-FC05FA4F6395 wds:Q84230049-4A2124C8-9113-4079-B5EB-4A2DB7486C3A wds:Q84230049-4BD3AD7F-3C6F-442B-8989-7781E143B7F7 wds:Q84230049-74FBB95A-8EE2-487C-83EE-2FE210DD9E05 wds:Q84230049-7A218A66-8B1B-4384-BC28-B6AC39175461 wds:Q84230049-81C7A4AF-E783-4E0A-9E0F-CE0FB3085036 wds:Q84230049-82EAC34D-B87B-4C24-A9E4-030FF34E4746 wds:Q84230049-83BF02B9-B14C-47B1-B8CF-63F314C13766 wds:Q84230049-9D894E01-E6FB-40B0-B735-83A564A6F67B wds:Q84230049-9F669B6C-3FB5-4649-A8AB-91CBB6927719 wds:Q84230049-A6E9F09F-9A03-4261-BC69-FCA9355389AE wds:Q84230049-A85CED76-8A59-4149-AE42-682FA76C32BB wds:Q84230049-AD2181A2-939A-4CD4-831A-5452604A4A66 wds:Q84230049-C7D31A7F-7879-4A29-B4F8-3152A6358C77 wds:Q84230049-DF640C0D-6B98-4822-BCCB-5924BA72B551 wds:Q84230049-E0B1C39F-297B-4F3B-9687-2D70F1A959BD wds:Q84230049-EDCC2CDF-CA8D-41F5-9B07-083CC90DA415 wds:Q84230049-FEC078F4-91DA-4D23-B754-4114F8AB647C
cites work	Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial. The MDM2 inhibitor Nutlins as an innovative therapeutic tool for the treatment of haematological malignancies A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cells miR-34a as part of the resistance network in chronic lymphocytic leukemia MDM2 inhibitors for cancer therapy Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia Human immunodeficiency virus type 1 envelope glycoprotein gp120-mediated killing of human haematopoietic progenitors (CD34+ cells). p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL). Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival Antiangiogenic Activity of the MDM2 Antagonist Nutlin-3 miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells 17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells miRNA analysis in B-cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR-150 and high BIC/miR-155 expression
author name string	wds:Q84230049-4CE02EFC-5C29-4DFE-8678-770B4453E80E wds:Q84230049-892F9C1D-BEB7-463B-8C44-DCF7DB0A6C1C wds:Q84230049-D3C80A74-4B3B-4A8E-A995-F669C85CF7F6 wds:Q84230049-DE282C1B-31CD-42F0-83CC-17183E47F5D3
author name string	Oriano Radillo Rebecca Voltan Maria Grazia di Iasio Riccardo Addobbati
rdfs:label	Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples (en) Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples (nl)
skos:prefLabel	Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples (en) Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples (nl)
name	Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples (en) Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples (nl)
title	wds:Q84230049-355ABDAD-B85E-4CCC-B9A4-8F35DAAE200B
title	Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples (en)
page(s)	wds:Q84230049-B9BFAAB8-FA14-4100-A08E-13CD3CD9674C
page(s)	1761-1765
instance of	wds:Q84230049-8137A880-5430-4043-A013-AAE139A99B5C
instance of	scholarly article
main subject	wds:Q84230049-001E11D8-6F07-4C4A-8DE1-B4364F5A9DCB
main subject	chronic lymphocytic leukemia
PubMed ID	wds:Q84230049-3BDC0C1A-ED6E-49EC-AF95-9846E033575D
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21626114
PubMed ID	21626114
published in	wds:Q84230049-E7822079-08F2-43E1-B047-41FFBFC4FB33
published in	Investigational New Drugs
issue	wds:Q84230049-1B8927A5-D5DE-41DD-A23E-3C8A69FD33D6
volume	wds:Q84230049-FA364BC7-2CAC-4B00-8443-FBD55D0F8711
issue	4
volume	30
DOI	wds:Q84230049-C37245BD-F64A-4981-A2E1-472D3697CCB8
DOI	http://dx.doi.org/10.1007/S10637-011-9695-4
DOI	10.1007/S10637-011-9695-4
Dimensions Publication ID	wds:Q84230049-CC87DDAB-FEAA-4373-946E-81A5C097B94F
Dimensions Publication ID	1012846418
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q84230049
is cites work of	SOCS1 is significantly up-regulated in Nutlin-3-treated p53wild-type B chronic lymphocytic leukemia (B-CLL) samples and shows an inverse correlation with miR-155. Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells

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