About: Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes

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About: Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes Goto Sponge NotDistinct Permalink

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scientific article published on 09 October 2008

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2008 (fr) наукова стаття, опублікована в жовтні 2008 (uk) artículu científicu espublizáu n'ochobre de 2008 (ast) scientific article published on 09 October 2008 (en)
publication date	wds:Q82254308-2F735005-7C2F-4030-9AB1-E45F25CBC85F
publication date	2008-10-09 00:00:00Z (xsd:dateTime)
author name string	wds:Q82254308-050EC420-A1EA-4CD4-BFF4-E0F8FD0413BD wds:Q82254308-4024E0C8-2250-4E24-836E-A66BE174F806 wds:Q82254308-45250EB4-91A2-4AC1-8B31-46B0D5FA560D wds:Q82254308-50D36DA7-D656-4347-A583-30029B2C667E wds:Q82254308-6D3F1742-F281-4B00-87A6-3E8E295C127E wds:Q82254308-84BB9D7B-E303-4CF2-9CCF-BF9C15656D0C wds:Q82254308-B333AE3D-7B06-49F9-A708-DCDABD6C643A wds:Q82254308-B9DAADB0-0B09-4D7D-9734-932C07E1CD9B wds:Q82254308-D94857C9-9F09-42B0-836F-8A5BEBA5FBF3 wds:Q82254308-DCEEDB03-08FE-4F0B-BEA2-233CF98D0A67 wds:Q82254308-F8AD645F-725F-45DC-BE8D-856DE3924128
author name string	Frederic J de Sauvage Radek C Skoda Adrian Wiestner Ralph Tiedt Johannes Schenkel Carl W Jackson Jörn Coers Svetlana Karakhanova Caroline Bornmann Hui Hao-Shen Sandra Ziegler
rdfs:label	Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes (en) Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes (nl)
skos:prefLabel	Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes (en) Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes (nl)
name	Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes (en) Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes (nl)
title	wds:Q82254308-FCA1A727-B2F1-45E8-AC56-234B44194528
title	Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes (en)
page(s)	wds:Q82254308-882C67C9-1601-4719-A53E-86F16E25CF95
page(s)	1768-1777
instance of	wds:Q82254308-F3F3805B-67FC-4EE5-858A-50DC69B9708A
instance of	scholarly article
PubMed ID	wds:Q82254308-7BF97BC4-6CA8-47DE-B92A-9D4E9D9559A4
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18845793
PubMed ID	18845793
published in	wds:Q82254308-52E7567E-EDAA-49DD-8253-E7F4ED9FA217
published in	Blood
issue	wds:Q82254308-2ED062FD-9365-47CE-B04E-0376E8CEE7D1
volume	wds:Q82254308-42FFCF0D-79F8-4B9D-B504-24AA68E58603
issue	8
volume	113
DOI	wds:Q82254308-53274DC6-0B8A-42F6-84C9-4B69A75E99F7
DOI	http://dx.doi.org/10.1182/BLOOD-2008-03-146084
DOI	10.1182/BLOOD-2008-03-146084
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q82254308
is cites work of	Mpl traffics to the cell surface through conventional and unconventional routes Toward a universal treatment for cancer: cell inflation assisted chemotherapy Role of tumor suppressor p53 in megakaryopoiesis and platelet function Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis Extracellular domain N-glycosylation controls human thrombopoietin receptor cell surface levels Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project. A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression. The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis Recent advances in understanding myelofibrosis and essential thrombocythemia Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation. Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice Platelet studies in autism spectrum disorder patients and first-degree relatives The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin Megakaryocyte development is normal in mice with targeted disruption of Tescalcin Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis Identification of MPL R102P Mutation in Hereditary Thrombocytosis. Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources Mouse models of diseases of megakaryocyte and platelet homeostasis. Evaluating the Role of Janus Kinase Pathways in Platelet Homeostasis Using a Systems Modeling Approach
is cites work of	wds:Q24299221-0E9D590B-369A-42D2-B709-307FC0A6A0B8 wds:Q54265169-4471EFAB-27DD-438E-80D3-8886DA2BD4D9 wds:Q33440994-E3509A55-1DC5-4801-A618-B4F999ED0303 wds:Q33386724-5F9878C9-ABCA-4DC9-8C94-B60256E8CE4B wds:Q41684028-D56184FA-4495-4267-AB19-EBA7EEF38CD5 wds:Q30486155-2BE619E1-40B7-4D45-BB69-FF0FBCCD407D wds:Q42157999-CF5D199C-DCE4-495D-9A36-1E339416EC19 wds:Q33419130-DB111ECA-DB99-4F7A-93F1-335C5A45AEE2 wds:Q24311471-68713F11-981C-4D54-B08C-3912E5DFE8C4 wds:Q38155169-4D8E889A-2CAA-4FF0-B2D4-B9B649239692 wds:Q30419441-30270CF6-A9C6-480E-BD5F-3C2C35867022 wds:Q92996966-B5290981-0AE5-45CE-AF63-3982C2AEDB9D wds:Q37888528-507EDF07-186D-431B-8CA1-9BF4D6F8EDB4 wds:Q34737531-9BEB92E0-51E4-4880-94C4-4EA578FB9B28 wds:Q36642197-49746BFE-92A6-4975-BC2E-90D1D9F14779 wds:Q42363263-5ACA425F-44F0-4EDB-9C22-2504D756CA30 wds:Q36203094-0C89B82C-B9FA-43CD-98EF-68AD00987F21 wds:Q34293019-AD816746-49F6-4C18-9F18-393BF1F4BFB7 wds:Q37725327-DB3AD537-EB72-4B2E-9ECE-09314343992C

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