About: Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex

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About: Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex Goto Sponge NotDistinct Permalink

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scientific article published on 01 December 2005

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2005 (fr) наукова стаття, опублікована в грудні 2005 (uk) artículu científicu espublizáu n'avientu de 2005 (ast) scientific article published on 01 December 2005 (en)
publication date	wds:Q81038742-CE4C7953-1BEF-4793-8828-13E3CE25BB49
publication date	2005-12-01 00:00:00Z (xsd:dateTime)
exact match	wds:Q81038742-FF48DAD3-ECD1-45E7-B4E6-4B19760EC0BD
exact match	https://scigraph.springernature.com/pub.10.1038/sj.onc.1208949
cites work	wds:Q81038742-00B24607-1113-4DEC-8A1E-A56768D4F50A wds:Q81038742-04EB7BE3-9B41-408C-99A3-5E920F27A6C7 wds:Q81038742-0C87CAA6-F23A-4987-B168-B91F14A5231D wds:Q81038742-28A230CA-CBCB-4786-A27B-D624309030BA wds:Q81038742-35C0A627-665E-4675-B429-4D20F1D37327 wds:Q81038742-3632A8E9-7489-4A92-9420-5C6045832CE8 wds:Q81038742-370C76B2-AFAF-499F-9780-DDBD02FEC8D5 wds:Q81038742-395762F4-C6A9-4F3E-8EBD-6CCE826110AE wds:Q81038742-42B681CC-A928-4DF5-ABE7-3CB528087DD0 wds:Q81038742-58940324-1C0E-4B66-B229-D186B6A2E363 wds:Q81038742-6202EC07-DF01-449F-B31D-9EE823F09D6E wds:Q81038742-70069497-949C-4C98-81AF-4573598E2C14 wds:Q81038742-7FB8108A-EEBC-4245-9544-3BCA06C3D2B3 wds:Q81038742-9194E32B-58BB-4E69-952E-DDA6EBE8EF1F wds:Q81038742-9B4BA78F-403A-4953-A728-4157D28C5BCF wds:Q81038742-B5F4AB34-D09F-475D-BE41-D4F2900BD821 wds:Q81038742-BC4B1F99-9F06-4E36-AAB8-2ABA5F03E1EE wds:Q81038742-C09D4E62-9DC1-4026-8528-FE95001D3465 wds:Q81038742-C8A32527-08CB-4CCF-8D6F-DB94750F2289 wds:Q81038742-D6E0EFE5-7ECF-4918-BEAA-8FE6ACA6B0C0 wds:Q81038742-D8E2423D-1EA4-4F72-BE26-1DD4D3BBBEA0 wds:Q81038742-DFF4CD60-2BB6-405D-936C-DFE364DDDB5A wds:Q81038742-E00F9E55-5805-4832-8622-F05ACA19E62C wds:Q81038742-EE5F97AA-C729-4A06-982D-2B055205164E wds:Q81038742-F6727992-E77C-491E-A889-F86BA6771230 wds:Q81038742-FB1E3171-BF91-496A-B383-6B636270ADDF wds:Q81038742-FB4232DC-BDCA-4557-81D6-503539D250C6
cites work	Bim: a novel member of the Bcl-2 family that promotes apoptosis Mcl-1. Modulation of cell death by Bcl-XL through caspase interaction Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. BCL-2 family members and the mitochondria in apoptosis MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12 BH3-Only proteins-essential initiators of apoptotic cell death The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells Myeloid cell factor-1 is a critical survival factor for multiple myeloma Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells. The Bcl-2 family: roles in cell survival and oncogenesis. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis. Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells Comparison of 200 mg/m(2) melphalan and 8 Gy total body irradiation plus 140 mg/m(2) melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergrou The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB. Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1. The substitution of the C-terminus of bax by that of bcl-xL does not affect its subcellular localization but abrogates its pro-apoptotic properties.
author name string	wds:Q81038742-392BD404-7D42-421E-BE4C-A35DEE0A5FE0 wds:Q81038742-4D82DD54-D260-40A2-B8C5-613B7FC39052 wds:Q81038742-6B985A86-27C5-4FD5-9DBF-53004EE472D2 wds:Q81038742-A622FC91-5A28-4C9A-BCCF-D0B7EC7E94EF
author name string	Steven Le Gouill Martine Amiot Régis Bataille Patricia Gomez-Bougie
rdfs:label	Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex (en) Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex (nl)
skos:prefLabel	Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex (en) Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex (nl)
name	Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex (en) Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex (nl)
author	wds:Q81038742-8F607976-CAD3-4D56-B557-8FC75396CDE9
author	Lisa Oliver
title	wds:Q81038742-5407BF86-F4BA-41BB-8ED5-880EB1ABCE54
title	Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex (en)
page(s)	wds:Q81038742-232D4605-0232-4BE5-BD62-550A26FE9A93
page(s)	8076-8079
instance of	wds:Q81038742-119F623A-2217-4338-A776-5897FED1E23E
instance of	scholarly article
main subject	wds:Q81038742-F21D40D1-D046-4BF1-8B2A-9DC531B95C5F
main subject	multiple myeloma
PubMed ID	wds:Q81038742-31A78EC8-AE6B-40AC-947F-AEEC3E3BE915
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16091744
PubMed ID	16091744
published in	wds:Q81038742-B6E2CE4D-6EAA-4CD3-9FC8-8C8280E97CFF
published in	Oncogene
issue	wds:Q81038742-8BA4B294-7218-47A6-96CE-1EA7AF438622
volume	wds:Q81038742-E684FB34-FD6D-477E-8A26-603816F1621F
issue	54
volume	24
DOI	wds:Q81038742-661D58C5-17BF-4AC4-B799-7092B7DA0567
DOI	http://dx.doi.org/10.1038/SJ.ONC.1208949
DOI	10.1038/SJ.ONC.1208949

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