About: Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

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About: Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice Goto Sponge NotDistinct Permalink

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research work

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття (uk) research work (en) article scientifique publié en 2007 (fr) im März 2007 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q80059540-19CCCAC0-3C38-4849-A46A-DDEBB06E866C wds:Q80059540-B5E84C73-72B1-47DA-808B-887690F7FEB3
publication date	2007-01-01 00:00:00Z (xsd:dateTime) 2007-03-29 00:00:00Z (xsd:dateTime)
exact match	wds:Q80059540-38DCE907-3BDC-4987-B904-BBFC5675E84C wds:Q80059540-901146ED-FF14-414C-AA4D-B21AAB4A15F8
exact match	https://scigraph.springernature.com/pub.10.1007/s00125-007-0637-9 http://ugspace.ug.edu.gh/handle/123456789/957
cites work	wds:Q80059540-0097CD07-07F6-4F67-A82A-DC7A3EF21202 wds:Q80059540-01E735B8-E392-4892-A125-6974270E8140 wds:Q80059540-033FF688-93C0-445D-A36D-21A58B5115A3 wds:Q80059540-05DADA76-6096-492A-8D9B-CBAE6E07B176 wds:Q80059540-0B1EA01E-DBBF-4E7A-8AE6-EAF1FA1B47F5 wds:Q80059540-0BEA414C-9576-4CC3-9CB7-951E8D578A07 wds:Q80059540-12F44813-7D43-47A8-9D38-76214CD9128C wds:Q80059540-1354F4F3-9144-4FBB-844D-C4B6D4532028 wds:Q80059540-1A80703E-8090-49A8-8BC7-018A187163F9 wds:Q80059540-2CA15F1F-D51F-441B-B05E-39401447CD3F wds:Q80059540-322FC331-8F9A-4FC9-8045-85CD2FEB68C0 wds:Q80059540-342C79D0-57F6-49AF-A71C-561E9C724B23 wds:Q80059540-572D225F-D85D-4CBF-8A02-1BDB8BF082A0 wds:Q80059540-65C3708B-536C-498A-8392-6E3AC1A1EDC9 wds:Q80059540-75F410F3-94FA-49EF-B0F4-9AA28CAAB29D wds:Q80059540-77A0A9B3-E7B9-46B7-801C-86EEEAA2FA18 wds:Q80059540-9B835B3F-5EC8-44E5-95BD-0378DFDFBD13 wds:Q80059540-AE594718-D153-4DBE-8B44-EC558D2E1D8C wds:Q80059540-AE64AE8B-5224-4EBF-A347-C6E51FE90ED0 wds:Q80059540-B2646580-2A79-4CAC-8812-6E7D7E097FE9 wds:Q80059540-B9A6AA3B-EAB6-4DBD-80E0-EBB96833A9C5 wds:Q80059540-BAA33F82-632D-4DF5-A805-548FCA675202 wds:Q80059540-C204822B-A846-483D-A81B-7D6F5D039E05 wds:Q80059540-C6155E6C-C607-47BF-88F7-2B6FF6F735FB wds:Q80059540-CBF8D18C-A8F8-42DF-8C9C-B6A1E7EBFEC8 wds:Q80059540-CF8C0A6B-907A-4543-9D5C-787285803032 wds:Q80059540-D72D800E-519B-46D5-8965-7D06CAC9A9AE wds:Q80059540-DABCF13E-D11D-4B2F-8EC3-1D4E8E3B3FA3 wds:Q80059540-DDD41CE3-29A6-4B18-9DBE-35ED50D13926 wds:Q80059540-E04A12E3-8462-4AF9-B488-271CA760C54E wds:Q80059540-F0D0F9AA-9D37-4940-B995-5EEA948BBD91 wds:Q80059540-F6FE2DE0-F12F-4134-8DBC-B53DBC07A4BE
cites work	Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. IRS-2 pathways integrate female reproduction and energy homeostasis Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes New perspectives into the molecular pathogenesis and treatment of type 2 diabetes Disruption of IRS-2 causes type 2 diabetes in mice Pdx1 restores beta cell function in Irs2 knockout mice A key role for beta-cell cytosolic phospholipase A(2) in the maintenance of insulin stores but not in the initiation of insulin secretion Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67 Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice. New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
author name string	wds:Q80059540-05DD96BF-21A6-4073-A4C1-3BC47E4B36D2 wds:Q80059540-1F3B2836-6DF3-4134-AEB2-54C57A4649AB wds:Q80059540-231626A2-F91C-4872-963F-7C86F1263442 wds:Q80059540-37B26CD7-16CA-4FBA-80A8-8A5F0CC5C663 wds:Q80059540-43F6DAB0-E8A2-46CA-9FA4-B03E1F375DAE wds:Q80059540-46853292-0B8B-45FF-AACA-B3AD708C205F wds:Q80059540-55132D20-4BF1-4D2B-A94D-B14CF743236A wds:Q80059540-5816DC27-2176-4FC7-9265-ECE686E4F045 wds:Q80059540-6B03619F-2FDE-45A6-AEFF-551DA5B33AE9 wds:Q80059540-9F74BFE2-A80D-44A2-B201-C431128A7522 wds:Q80059540-A2FD77A7-A575-429F-9CDF-31FB15D3D597 wds:Q80059540-BB12FB49-90AF-4D30-BDD1-073AA02323C1 wds:Q80059540-EAA61ADF-DE55-4570-99B8-E2301D8148FE wds:Q80059540-EB2872C6-1E7D-422D-BB81-CEF6D07CC9D3
author name string	P Herrera A I Choudhury Anane-Asare, H. H Asare-Anane Cantley, J. Choudhury, A. I. H Heffron Heffron, H.

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