About: The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel

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About: The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel Goto Sponge NotDistinct Permalink

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scientific article published on 01 December 1998

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в грудні 1998 (uk) im Dezember 1998 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'avientu de 1998 (ast) scientific article published on 01 December 1998 (en)
publication date	wds:Q77701461-CE851B47-D8ED-4396-AC90-A06DCBDA0091
publication date	1998-12-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q77701461-A1D53C74-A47E-4C65-BD56-60A1BDD91174
language of work or name	English
author name string	wds:Q77701461-25DB3668-3464-4A86-AD47-B93B4166D92C wds:Q77701461-458538B4-B905-4263-9F14-581C1588C687 wds:Q77701461-92045C9D-E190-45CF-A033-9515E548016E wds:Q77701461-BBC196B5-BBBB-428B-8FC7-DE8509C1E836
author name string	J P Cazenave P Ohlmann B Hechler C Gachet
rdfs:label	The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel (en) The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel (nl)
skos:prefLabel	The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel (en) The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel (nl)
name	The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel (en) The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel (nl)
author	wds:Q77701461-CAF4540A-07D5-4848-B9BC-1DA393D6D898
author	A Eckly
title	wds:Q77701461-6C1505BF-51BE-4D8A-B415-63DE5623479B
title	The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel (en)
page(s)	wds:Q77701461-F5D64F2C-4855-4420-B322-89C52A6A5DD4
page(s)	858-866
instance of	wds:Q77701461-6056711C-0B1D-40B4-9CBC-59FAF04E9E53
instance of	scholarly article
main subject	wds:Q77701461-6C9A8669-F105-4CE3-A77B-BC742F8F3540 wds:Q77701461-87D6D0E6-6F02-4716-835A-41E631E8590A
main subject	wd:Q410237 platelet aggregation
PubMed ID	wds:Q77701461-84587584-2B14-4C4E-9408-415DD9426B94
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9858246
PubMed ID	9858246
published in	wds:Q77701461-1BF669B4-A365-4D5D-8359-C3B7CCBF332C
published in	British Journal of Haematology
issue	wds:Q77701461-A944CA92-C41E-4FDE-ABE6-4BF64717C0CC
volume	wds:Q77701461-41490412-4D3F-48F2-ADC1-A8F55A7DCE29
issue	3
volume	103
DOI	wds:Q77701461-0479C8BA-4E11-415C-9EE5-9A6C4262210F
DOI	http://dx.doi.org/10.1046/J.1365-2141.1998.01056.X
DOI	10.1046/J.1365-2141.1998.01056.X
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q77701461
is cites work of	Clopidogrel: a review of its use in the prevention of atherothrombosis Pharmacology of the new P2Y12 receptor inhibitors: insights on pharmacokinetic and pharmacodynamic properties. ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors Identification of the platelet ADP receptor targeted by antithrombotic drugs International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs Platelet inhibition with prasugrel (CS-747) compared with clopidogrel in patients undergoing coronary stenting: the subset from the JUMBO study Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999 (N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice Impaired activation of murine platelets lacking G alpha(i2) P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist Characterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins Identification, characterization, and inhibition of the platelet ADP receptors P2 receptors and platelet function Activity of adenosine diphosphates and triphosphates on a P2Y(T) -type receptor in brain capillary endothelial cells Haemolysis induced by α-toxin from Staphylococcus aureus requires P2X receptor activation. Vasodilatation of intrapulmonary arteries to P2-receptor nucleotides in normal and pulmonary hypertensive newborn piglets Purification and Functional Reconstitution of the Human P2Y12Receptor Metabotropic P2Y receptors inhibit P2X3 receptor-channels via G protein-dependent facilitation of their desensitization. Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1. Inhibition of platelet aggregation and the release of P-selectin from platelets by cilostazol Role of ADP receptors on platelets in the growth of ovarian cancer Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential. P2Y12 receptor: platelet thrombus formation and medical interventions. Novel uses for anti-platelet agents as anti-inflammatory drugs. 4-Benzothiazole-7-hydroxyindolinyl diaryl ureas are potent P2Y1 antagonists with favorable pharmacokinetics: low clearance and small volume of distribution Historical perspective on ADP-induced platelet activation Current developments in anti-platelet therapy Pharmacodynamic interplay of the P2Y(1), P2Y(12), and TxA(2) pathways in platelets: the potential of triple antiplatelet therapy with P2Y(1) receptor antagonism
is cites work of	wds:Q24290587-97898E32-5986-46EC-B51F-D84068A8322D wds:Q35041833-D59F004E-3D8C-4E2C-A2D7-58487B4D844B wds:Q35130686-F84BB910-DCF2-4F9F-9437-00573B5A8465 wds:Q36173822-4E1A5CEF-9A1B-4D92-BC51-6CF6987D50F7 wds:Q44689561-A35B90D6-95D0-4A4D-9E7E-D347D35BBA4A wds:Q28367095-3A1A1576-6810-4EBE-B3F6-93BFFB6E899D wds:Q24290845-F9820786-E32F-4BD5-B803-510141CBAC17 wds:Q28345855-82A5A442-64FE-40C2-BA45-29AB812686B9 wds:Q34141735-2BAFC822-9EB4-46D0-9A51-9B485635BE58 wds:Q45869485-D354C53B-9EF1-4191-BA6B-DEBB4099BC8B wds:Q58486856-0020D636-43C9-4CF0-8682-D393378600B6 wds:Q31882653-03EF6E72-C34F-461E-A011-FA9DA6B31971 wds:Q26861200-B7040BC2-49F9-4707-9337-EA5B854722E9 wds:Q24629255-400F99F6-991D-4E7F-9C00-F5F2151815F0

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