About: Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

scientific article published on 01 June 1998

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в червні 1998 (uk) im Juni 1998 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xunu de 1998 (ast) scientific article published on 01 June 1998 (en)
publication date	wds:Q77134006-C1CEBBF1-B3C3-4BF6-A423-51A7F5FA481E
publication date	1998-06-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q77134006-151C74DE-2A94-4B49-8A2E-D7A4B638D763
language of work or name	English
cites work	wds:Q77134006-12F0755F-5C70-4EB8-9229-5E5F9840D969 wds:Q77134006-1ADBF839-4829-4370-8944-13ED643F014B wds:Q77134006-24BEAE65-AF47-4589-A87C-1AB2ED29DACE wds:Q77134006-3659CBAC-4E38-4187-9C78-6BFF524E88BE wds:Q77134006-390D6F5F-37FE-426F-B1D4-72AA83563E72 wds:Q77134006-397C5ACE-B9A2-4A7A-A964-3F24DC2B1CAA wds:Q77134006-3A9E4D60-021F-4105-A3C5-04E4F2612B30 wds:Q77134006-3F9A60D1-207C-49C0-8A1C-AA5247CED00B wds:Q77134006-435729AB-DEF4-4BEA-9A37-47FA0C4A94E3 wds:Q77134006-49C0CB6E-915B-4538-8B7F-2A9535D4500E wds:Q77134006-556116BE-D586-4110-A5BC-4B97B533718F wds:Q77134006-5FC94D5F-DA1F-4FAC-900F-9CD075CB7AF9 wds:Q77134006-60F082CD-F1EB-48E3-A962-1F8A72E20635 wds:Q77134006-622EEC08-AF07-408D-953E-330D81DD4DB9 wds:Q77134006-67777D0C-9A31-4A14-AECA-786ABF17D9B4 wds:Q77134006-71413FE8-E794-4B05-B7D8-B15EB0FC99A6 wds:Q77134006-7E0A46D8-15AD-44EC-9ADE-85F9AAFB4E74 wds:Q77134006-8792A92B-6751-4DD2-B53C-DC58AB65A452 wds:Q77134006-8B6A3C27-EFC0-4E2C-AE57-4499D1AFAA3C wds:Q77134006-9D1550EE-3452-4DD8-B988-8DDF5F1D3701 wds:Q77134006-9D7C2556-EAF6-4549-9E1B-6454754651C0 wds:Q77134006-A01ACCF9-6E88-4132-AEB8-1FC4F919224B wds:Q77134006-AC94241A-7B20-419B-9AD8-5CD1B8948560 wds:Q77134006-BF09A9FA-1428-40C0-AF99-8D91E0BB3ABF wds:Q77134006-C743B657-5671-4387-AD06-614EC3B876C1 wds:Q77134006-C870723B-40CF-4106-B42D-C238457B2B25 wds:Q77134006-F34A3954-2249-4DAD-807C-6454DF7C7932 wds:Q77134006-F9ABE0AC-5646-4464-BF17-D72961D5393D wds:Q77134006-F9F0EA20-63C3-4627-8FB5-EFF1F862ACA1 wds:Q77134006-FD059E5D-A626-4BFB-8DAA-240EF708D642 wds:Q77134006-FD789464-7CE7-4E52-A4D4-A5B2A714B37F wds:Q77134006-FE70FA16-A9CF-45C4-A5E5-97B8022423E9
cites work	Role of CYP2E1 in the hepatotoxicity of acetaminophen P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Histopathologic examination of the rat nasal cavity Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes Paracetamol-induced acute renal failure in the absence of fulminant liver damage. Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity. S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models Modulation of rat hepatic microsomal monooxygenase enzymes and cytotoxicity by diallyl sulfide. Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity Immunolocalization of cytochromes P-450olf1 and P-450olf2 in rat olfactory mucosa cDNA cloning, heterologous expression, and characterization of mouse CYP2G1, an olfactory-specific steroid hydroxylase. Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta'-iminodipropionitrile (IDPN) in the rat. Renal necrosis, glutathione depletion, and covalent binding after acetaminophen Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite. Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen Nasal diagrams: a tool for recording the distribution of nasal lesions in rats and mice. Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity Molecular engineering of microsomal P450 2a-4 to a stable, water-soluble enzyme. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4 Identification of the mouse liver 44-kDa acetaminophen-binding protein as a subunit of glutamine synthetase. Steroid metabolism by rabbit olfactory-specific P450 2G1 Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen. Protection by dimethylsulfoxide against acetaminophen-induced hepatic, but not respiratory toxicity in the mouse Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis Acute renal failure after analgesic drugs including paracetamol (acetaminophen) The effect of propylene glycol on the P450-dependent metabolism of acetaminophen and other chemicals in subcellular fractions of mouse liver Extrahepatic lesions induced by acetaminophen in the mouse Prednisolone stimulates hepatic glutathione synthesis in mice. Protection by prednisolone against acetaminophen hepatotoxicity in vivo
author name string	wds:Q77134006-1A4118B5-A286-4BFD-9084-123B6BBD396C wds:Q77134006-2219F8DC-AFAB-4547-95B2-2BDC1963760A wds:Q77134006-29EA3838-5DE7-4492-98C3-14D856F43B1A wds:Q77134006-51D378CD-5F53-4586-851A-ABE8E48318A4 wds:Q77134006-A4285061-E7BF-460C-BA9F-901890A2F5DC wds:Q77134006-CD2E1444-332D-4EB6-9D14-F3F9C9843A92
author name string	M Negishi X Ding D W Nebert J Gu H C Liang M B Genter
rdfs:label	Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse (en) Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2 (nl)
skos:prefLabel	Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse (en) Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2 (nl)
name	Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse (en) Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2 (nl)
author	wds:Q77134006-3EAD4F8E-D83F-4439-9B97-D2BACEB18789
author	Ross A. McKinnon
title	wds:Q77134006-9C1EAEC1-C791-41F5-BA69-60886717A313
title	Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse (en)
page(s)	wds:Q77134006-F48A2FA3-C1C9-4A84-84EF-CA426B1955F5
page(s)	1819-1826
instance of	wds:Q77134006-3DD20099-CF6B-4FCC-9657-679D369B8E2D
instance of	scholarly article

Faceted Search & Find service v1.16.117 as of May 05 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of May 5 2024, on Linux (x86_64-centos_6-linux-gnu), Single-Server Edition (378 GB total memory, 180 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software