About: A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

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About: A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy Goto Sponge NotDistinct Permalink

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scientific article published on 01 May 2002

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 2002 (uk) article scientifique publié en 2002 (fr) im Mai 2002 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en mayu de 2002 (ast) scientific article published on 01 May 2002 (en)
publication date	wds:Q74117541-3A0BE017-5ADF-4076-9BF3-6BB37C63CE72
publication date	2002-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q74117541-A7B6FDED-8CF0-4D85-99BA-42F61A634107
language of work or name	English
cites work	wds:Q74117541-03CE5245-B0D0-4892-84E2-DD892DB47943 wds:Q74117541-088A299C-E419-4B20-9534-95F124C7E05D wds:Q74117541-0A1B9A0D-2798-4A76-A202-8938AEEE1572 wds:Q74117541-22EB67A9-FFA6-4113-A945-2297E39BBC4C wds:Q74117541-3119F482-A272-4CCF-AFA8-6E185D55AA96 wds:Q74117541-36234216-DFB3-46BB-A736-98A626DB1393 wds:Q74117541-45225AB4-C3BB-46D3-B248-DFE00428B227 wds:Q74117541-455EC2FA-E915-4DCE-A2DA-2E5C5623D1CE wds:Q74117541-4FEE5DE1-1B7B-44A3-BB6B-F189F14B3009 wds:Q74117541-55CB4BDB-29E2-4536-B765-9C3870994582 wds:Q74117541-56218252-F8E8-4936-857A-4DE6C7596A45 wds:Q74117541-665F8CBC-7E4B-4A50-A023-1E2F2E5BA736 wds:Q74117541-68230C64-6507-4834-BF35-4E045BD252D2 wds:Q74117541-854DF565-7B4B-410F-B50D-256C897DEBB2 wds:Q74117541-9015163E-59E1-4BF0-A611-A9598826EF9D wds:Q74117541-94C10A96-ABEF-4208-8FF8-4B7E6D0445F9 wds:Q74117541-9B8A761D-74F4-4CA0-9F62-98B71BF5B017 wds:Q74117541-9EC71FC7-9B8C-4E03-8916-8EBAC2792006 wds:Q74117541-A1C8B938-5B23-44CF-99BF-4882B2604AB6 wds:Q74117541-AEA1FCD2-C030-4945-8C8D-9EF25118B03B wds:Q74117541-B5411CF8-5F7D-4100-884C-2F9BEA4B3AF6 wds:Q74117541-B6B43D7E-90B2-4C12-B771-ABE30E442BBE wds:Q74117541-B8B296F0-FF87-4EC5-B03D-42B0CB54F213 wds:Q74117541-BCFF0C8F-F560-4686-B4AE-F4AB3A2FBDB7 wds:Q74117541-CDDC369B-9C4A-4516-979B-0E51B24F63AC wds:Q74117541-E63669F7-E6AF-4A42-9369-D3D9AA8D0E72 wds:Q74117541-EA6A2249-C257-4A43-B255-87B170999367 wds:Q74117541-F6662EC7-C50F-44BA-AA58-1CB6EF6DABB6 wds:Q74117541-F79DEB04-4F65-4A8F-851C-0D6BDED7BEE2 wds:Q74117541-F7A12B64-E01E-49C7-96F1-507B665C855C wds:Q74117541-FA8D7EA6-6238-42AA-A056-CDCDCD8B9632
cites work	DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts A biomarker that identifies senescent human cells in culture and in aging skin in vivo The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genetic analysis of chemoresistance in primary murine lymphomas. The INK4a/ARF network in tumour suppression Apoptosis: a link between cancer genetics and chemotherapy p53-dependent apoptosis modulates the cytotoxicity of anticancer agents Surfing the p53 network Requirement for p53 and p21 to sustain G2 arrest after DNA damage p16INK4A and p19ARF act in overlapping pathways in cellular immortalization Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Genetic determinants of response to chemotherapy in transgenic mouse mammary and salivary tumors Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence Disruption of p53 in human cancer cells alters the responses to therapeutic agents Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts The serial cultivation of human diploid cell strains E1A signaling to p53 involves the p19(ARF) tumor suppressor Dual inactivation of RB and p53 pathways in RAS-induced melanomas Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening Cellular senescence: mitotic clock or culture shock? Dissecting p53 tumor suppressor functions in vivo Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages Cell-cycle arrest versus cell death in cancer therapy Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice Parsing Ink4a/Arf: "pure" p16-null mice Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo DNA damage responses and chemosensitivity in the E mu-myc mouse lymphoma model.
author name string	wds:Q74117541-6638C9F9-56D1-4F04-A967-4889CF6BCA55 wds:Q74117541-6B224A62-EF6D-45F3-ACF8-7DF41E2249EB wds:Q74117541-707AEE46-D0E0-4EDE-A7FC-A00343B28CFE wds:Q74117541-8538E316-A7C1-49CA-A446-6B74982E5503 wds:Q74117541-9A2FC31B-4A7D-449C-9F22-4FAD0770371A wds:Q74117541-FB57D956-FFE5-4C80-9F2E-76390E479940
author name string	Scott W Lowe Robert M Hoffman Meng Yang Eugene Baranov Jordan S Fridman Clemens A Schmitt
rdfs:label	A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy (en) A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy (nl)
skos:prefLabel	A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy (en) A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy (nl)
name	A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy (en) A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy (nl)
author	wds:Q74117541-23D1219B-DD1E-439C-ADA0-0F728F8D3367
author	Soyoung Lee
title	wds:Q74117541-04D3BA88-F409-4600-ACF3-B5152BA4AC47
title	A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy (en)
page(s)	wds:Q74117541-9A3B66EE-15A2-434D-89A6-92245E80550D
page(s)	335-346
instance of	wds:Q74117541-2999E24D-5654-4BD9-994D-85C0E364C4FF
instance of	scholarly article
PubMed ID	wds:Q74117541-2D6E9865-7BA6-44F4-A49D-93C746B39ACE

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