About: Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation

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About: Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation Goto Sponge NotDistinct Permalink

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scientific article published on 21 May 2001

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 2001 (uk) im Mai 2001 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en mayu de 2001 (ast) scientific article published on 21 May 2001 (en)
publication date	wds:Q73919703-B298FA5F-EADE-4191-BAC7-3762B5EFE614
publication date	2001-05-21 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73919703-40EDEDC0-8515-4164-8C96-AE9A4D0AAC2D
language of work or name	English
cites work	wds:Q73919703-0B1AD637-5A56-4068-AFEC-970A9F1E5621 wds:Q73919703-16DE05DC-B52C-41A3-8B1D-E3E7ABC21440 wds:Q73919703-185B98EE-DE03-49E5-BF0E-6BF9CDF72DFA wds:Q73919703-21D345FB-EB4C-47E0-AAA7-6E4182CAC8A7 wds:Q73919703-2A4E8D5F-DADA-44A0-AF25-E7AC173FEE85 wds:Q73919703-2C419E4E-86B4-4691-BCED-488A77EE8C5F wds:Q73919703-3428986B-6309-4E8E-BC1E-6E8C5A1C2839 wds:Q73919703-37D28854-FC0A-4E7A-8D3C-4ECD579F2B66 wds:Q73919703-3845BEFC-902D-424A-B7DE-474F8447A488 wds:Q73919703-3E115099-10AC-48C6-899A-4FD20688412C wds:Q73919703-43678F6B-C18A-4305-9965-629F7A6BA862 wds:Q73919703-4A4B59C8-ADD0-4B72-AC51-4F24A5A5C00A wds:Q73919703-60648421-908E-450C-BFF0-DC36A5ADFA90 wds:Q73919703-62575385-BE37-4EEA-BF47-BEF2DAB83088 wds:Q73919703-6717062B-0187-47F1-BC49-7FEFCA23C4E2 wds:Q73919703-72956856-2C70-443E-808A-A33238C7728B wds:Q73919703-77257CE5-A6E5-4CBD-B1BE-9762F9B170F3 wds:Q73919703-7DA967B7-FAE5-4394-A3E9-480261F8A386 wds:Q73919703-811F09BC-3A36-41F8-83CD-BB3C2DFC6F95 wds:Q73919703-B33990F2-896E-4160-9727-E7E491FA4F10 wds:Q73919703-BE69C19B-B367-4B47-B910-F0024F4D5C82 wds:Q73919703-C15C9311-E81B-4ED0-8DA5-E7EF4D7E9B99 wds:Q73919703-CDCB5934-F863-4D81-8A94-E4289BC1D679 wds:Q73919703-F424C48C-2B98-4D73-89BB-A12CE37BA455
cites work	Crystal structure of the proenzyme domain of plasminogen Chymotrypsinogen: 2,5-Å crystal structure, comparison with α-chymotrypsin, and implications for zymogen activation The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-tryp Structural basis of the activation and action of trypsin Human plasminogen catalytic domain undergoes an unusual conformational change upon activation Calculation of protein extinction coefficients from amino acid sequence data Crystal structure of the catalytic domain of human plasmin complexed with streptokinase Induction of the bovine trypsinogen-trypsin transition by peptides sequentially similar to the N-terminus of trypsin Thioester peptide chloromethyl ketones: reagents for active site-selective labeling of serine proteinases with spectroscopic probes Analogs of human plasminogen that are labeled with fluorescence probes at the catalytic site of the zymogen. Preparation, characterization, and interaction with streptokinase Streptokinase binds to human plasmin with high affinity, perturbs the plasmin active site, and induces expression of a substrate recognition exosite for plasminogen Plasminogen activator activities of equimolar complexes of streptokinase with variant recombinant plasminogens. Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes The mechanism of activation of human plasminogen by streptokinase Deletion of Ile1 changes the mechanism of streptokinase: evidence for the molecular sexuality hypothesis 29 Human plasminogen Streptokinase binds preferentially to the extended conformation of plasminogen through lysine binding site and catalytic domain interactions Zymogen activation in the streptokinase-plasminogen complex. Ile1 is required for the formation of a functional active site Complete amino acid sequence of streptokinase and its homology with serine proteases Purification and characterization of streptokinase with studies of streptokinase activation of plasminogen Kinetic mechanism of the activation of human plasminogen by streptokinase Identification of a plasminogen binding region in streptokinase that is necessary for the creation of a functional streptokinase-plasminogen activator complex A proposal for the mechanism of chymotrypsinogen activation Interaction of streptokinase and plasminogen. Studied with truncated streptokinase peptides
author name string	wds:Q73919703-68187B1D-0A95-44BA-9788-078445186919 wds:Q73919703-6A25E97F-8828-4715-92B9-78EB8E3C4B92 wds:Q73919703-CB5EA81F-5F2A-44D0-BEEE-01B4B57C5BFD wds:Q73919703-CD77E313-53E4-4482-898A-5275AC2D9884
author name string	Fay WP Bock PE Boxrud PD Verhamme IM
rdfs:label	Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation (en) Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation (nl)
skos:prefLabel	Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation (en) Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation (nl)
name	Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation (en) Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation (nl)
title	wds:Q73919703-C5EB07DF-C06B-4826-93F1-1CE36B6C6A2A
title	Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation (en)
page(s)	wds:Q73919703-E9E5DE80-C05F-4D7E-8E90-C8A3110D6D17
page(s)	26084-26089
instance of	wds:Q73919703-C206ACBB-68B7-4657-817F-7DFF89D778C1
instance of	scholarly article
main subject	wds:Q73919703-8249C625-1C64-456A-9CCE-BAE9AE156225 wds:Q73919703-DFD5DD8B-1791-4E8E-B211-7DC44C6F9C48
main subject	plasminogen Streptokinase
PubMed ID	wds:Q73919703-9BA42480-F721-4CD1-8EDE-80AD6D896C33
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11369771
PubMed ID	11369771
published in	wds:Q73919703-27840E7C-D948-416A-A2AB-97CC8E222A07
published in	Journal of Biological Chemistry
issue	wds:Q73919703-1D6B32BE-40AF-4628-AD1A-223DB33EA664
volume	wds:Q73919703-0C9F8548-DB9F-44C7-90A4-C64CF0C64B03
issue	28
volume	276
number of pages	wds:Q73919703-6150DC5B-F9A5-4073-979F-B9EE8FFB70FD
number of pages	6 (xsd:decimal)
DOI	wds:Q73919703-DCA050C8-5092-4704-ACEC-587856E6D13F
DOI	http://dx.doi.org/10.1074/JBC.M101966200
DOI	10.1074/JBC.M101966200
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73919703
is cites work of	Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation Involvement of a nine-residue loop of streptokinase in the generation of macromolecular substrate specificity by the activator complex through interaction with substrate kringle domains Streptokinase--the drug of choice for thrombolytic therapy

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