About: In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

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About: In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 Goto Sponge NotDistinct Permalink

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scientific article published on 01 October 1997

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в жовтні 1997 (uk) article scientifique publié en 1997 (fr) im Oktober 1997 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'ochobre de 1997 (ast) scientific article published on 01 October 1997 (en)
publication date	wds:Q73802072-981DC9F9-BD73-459B-ADB9-DAF09C336ADE
publication date	1997-10-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73802072-B4AB866C-93AC-4B64-8E64-95EFDFF6496A
language of work or name	English
author name string	wds:Q73802072-283007B5-7539-495E-89B2-B6A55D2DBFD0 wds:Q73802072-2EAAC5D3-649D-4A36-8C40-0614F6A76AEC wds:Q73802072-874E1168-648B-465F-91AE-7E1FA172A600 wds:Q73802072-914E74EB-194B-464C-B292-7F99FA7875EC wds:Q73802072-B0C2817E-CB31-481A-A1E4-F796BF02A4CD wds:Q73802072-EA5234E5-9F1C-4DCB-8BE0-9E73678BE691 wds:Q73802072-ED76864D-3C31-4E52-A442-7388B9DA3594 wds:Q73802072-F69722E4-962F-4480-A03C-212DC9FDD2DB
author name string	Compton DS Sybertz EJ Alton KB Davis HR Jr McLeod RL Van Heek M France CF Yumibe NP
rdfs:label	In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 (en) In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 (nl)
skos:prefLabel	In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 (en) In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 (nl)
name	In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 (en) In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 (nl)
title	wds:Q73802072-B738D7E9-729A-4DA3-A635-41B515B17490
title	In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 (en)
page(s)	wds:Q73802072-2E341FF0-8B2A-437A-99BE-E71AB0687394
page(s)	157-163
instance of	wds:Q73802072-8524EDC9-0733-4EFE-8D19-9748E6596B50
instance of	scholarly article
PubMed ID	wds:Q73802072-98DA1F41-6341-45D4-8426-9879F30127BD
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9336320
PubMed ID	9336320
published in	wds:Q73802072-428BA109-4C20-43BC-BB2E-BD154329D76D
published in	Journal of Pharmacology and Experimental Therapeutics
issue	wds:Q73802072-42ABFF95-F6AB-47DC-9209-A341A5E053B3
volume	wds:Q73802072-A8CC9847-B941-45FF-B1F7-CF2DB5E0714C
issue	1
volume	283
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73802072
is cites work of	Ezetimibe: a novel cholesterol-lowering agent that highlights novel physiologic pathways Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663 Hypercholesterolemia and myocardial function evaluated via tissue doppler imaging Ezetimibe reduces plaque inflammation in a rabbit model of atherosclerosis and inhibits monocyte migration in addition to its lipid-lowering effect Fenofibrate: a novel formulation (Triglide) in the treatment of lipid disorders: a review Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia Phenotypic screens as a renewed approach for drug discovery Monogenic hypercholesterolemia: new insights in pathogenesis and treatment The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1) High-density lipoprotein (HDL) cholesterol: leveraging practice-based biobank cohorts to characterize clinical and genetic predictors of treatment outcome RETRACTED: Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport Emerging roles of the intestine in control of cholesterol metabolism. Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption? Zebrafish lipid metabolism: from mediating early patterning to the metabolism of dietary fat and cholesterol Role of selective cholesterol absorption inhibition in the management of dyslipidemia Effects of ezetimibe and simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia. Pharmacology and therapeutics of ezetimibe (SCH 58235), a cholesterol-absorption inhibitor Comparison of Ezetimibe/Simvastatin 10/20 mg Versus Atorvastatin 20 mg in Achieving a Target Low Density Lipoprotein-Cholesterol Goal for Patients With Very High Risk New insights into the molecular mechanism of intestinal fatty acid absorption Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption Achievement of low-density lipoprotein cholesterol goals: new strategies to address new guidelines Heterozygous familial hypercholesterolaemia in childhood: cardiovascular risk prevention Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles Comparative study of ezetimibe and atorvastatin alone and in combination on lipid profile in rats Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor ezetimibe and simvastatin Therapeutic strategies to deplete macrophages in atherosclerotic plaques Effect of fixed-dose combinations of ezetimibe plus rosuvastatin in patients with primary hypercholesterolemia: MRS-ROZE (Multicenter Randomized Study of ROsuvastatin and eZEtimibe). A new model system swims into focus: using the zebrafish to visualize intestinal metabolism in vivo Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double knockout mice Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice. In vivo effects of anacetrapib on preβ HDL: improvement in HDL remodeling without effects on cholesterol absorption Ezetimibe inhibits hepatic Niemann-Pick C1-Like 1 to facilitate macrophage reverse cholesterol transport in mice Disruption of cholesterol homeostasis by plant sterols Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8) Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish. Regulation of intestinal lipid metabolism: current concepts and relevance to disease An HPLC-CAD/fluorescence lipidomics platform using fluorescent fatty acids as metabolic tracers. Cholesterol absorption inhibitors: defining new options in lipid management. Protein mediators of sterol transport across intestinal brush border membrane Efficacy and safety of coadministration of ezetimibe and statins in elderly patients with primary hypercholesterolaemia Management strategies of dyslipidemia in the elderly: 2005. Newer pharmaceutical agents to treat lipid disorders Sitosterolaemia in Switzerland: molecular genetics links the US Amish-Mennonites to their European roots. Effects of ezetimibe and anticoagulant combined therapy on progressing stroke: a randomized, placebo-controlled study. Efficacy and safety of coadministration of ezetimibe and simvastatin in African-American patients with primary hypercholesterolemia.

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