About: Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-deficient patients expressing high levels of Syk

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About: Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-deficient patients expressing high levels of Syk Goto Sponge NotDistinct Permalink

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scientific article published on 01 May 2000

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 2000 (uk) article scientifique publié en 2000 (fr) im Mai 2000 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en mayu de 2000 (ast) scientific article published on 01 May 2000 (en)
publication date	wds:Q73626684-C4D7D807-D551-47EC-A1BC-10FE43A0BFB0
publication date	2000-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73626684-E323CAB5-83C0-4FBB-90E4-8EC9F0F76440
language of work or name	English
cites work	wds:Q73626684-0062A700-35B6-471E-B01C-BDE96262EE92 wds:Q73626684-0A8F201F-5033-4AF4-BF94-029082C8D687 wds:Q73626684-24E11124-0E49-4162-B04B-D5F0F8D52813 wds:Q73626684-24FEEC30-3185-48AC-BB38-665B38852854 wds:Q73626684-27BE03A0-DC1C-4693-BEE1-2569FED620D9 wds:Q73626684-28350EEF-22CE-4F96-9EB7-0F1DF9AA5D3C wds:Q73626684-2B14C298-CB2A-46C1-A6BF-8FFE4010E4AA wds:Q73626684-3DDAE325-9490-45ED-A78B-671E7E5162FC wds:Q73626684-51F4F0AC-7381-498A-993E-9BE24284A2EE wds:Q73626684-566FAE1C-D91E-42DC-94FA-39B63612802C wds:Q73626684-5844B430-BB59-476E-AE5D-0EC9C654894C wds:Q73626684-59FE5109-DD22-4133-B3F4-6739B87B798A wds:Q73626684-62291854-45D0-4F29-910B-98FCEECD1DF3 wds:Q73626684-723E48A9-F7CE-41BE-AB8F-9AADB913AFE0 wds:Q73626684-7E97D120-CF9A-4098-90F7-6A83767D4A37 wds:Q73626684-7EC339A3-CAB0-4E7A-8E99-978D1A3EAF4F wds:Q73626684-812E3AD6-06A7-4822-8802-912470CC9F03 wds:Q73626684-81BB59D3-5ACD-478B-A7F4-194379FCCE4D wds:Q73626684-840BF4C8-0DB6-435C-ACBE-5B61BF6FB66C wds:Q73626684-87FBECED-2801-43D4-9FB6-042DEE3AB82B wds:Q73626684-8E319A71-10E1-4EB8-B993-4BD770EF0915 wds:Q73626684-A1F2B45D-9A28-446A-B06C-8F360E85CBD8 wds:Q73626684-BA841D7B-DECC-4644-A876-592B520F14BB wds:Q73626684-BFA62ABC-87D3-4942-A6BD-15E1868A618D wds:Q73626684-C91E1A39-88BE-4848-8A01-80EF45B623AE wds:Q73626684-CEA79D44-EE81-4C93-AC1B-DBA582D22D4D wds:Q73626684-D5743646-D27F-4DEA-9AFE-BD37833564E7 wds:Q73626684-D5EC2143-AD6A-49C7-A44C-5D67175F96C8 wds:Q73626684-DAAF8617-DCFD-45FA-A226-CFB7D07D112F wds:Q73626684-F755811E-86E6-4552-8796-851A9DECD347 wds:Q73626684-FAC8622C-16B3-4045-AB5C-94D7B9162D21 wds:Q73626684-FF04119B-A9C9-4DA3-9C91-201D73D1E22F wds:Q73626684-FF074DC1-81B4-48DE-A564-1A21EA9954B7
cites work	Differential activation of transcription factors induced by Ca2+ response amplitude and duration Essential role for ZAP-70 in both positive and negative selection of thymocytes A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation The Syk family of protein tyrosine kinases in T-cell activation and development Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK JNK is involved in signal integration during costimulation of T lymphocytes. Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes T cell antigen receptor signal transduction pathways JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation T cell activation by clustered tyrosine kinases Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase Direct evidence that ERK regulates the production/secretion of interleukin-2 in PHA/PMA-stimulated T lymphocytes The regulation and function of p21ras during T-cell activation and growth. The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase Recombinant interleukin 2 therapy in severe combined immunodeficiency disease Temperature-sensitive ZAP70 mutants degrading through a proteasome-independent pathway. Restoration of a kinase domain mutant by Cdc37. Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules
author name string	wds:Q73626684-016428D1-CFBD-4D43-90CA-33713134432C wds:Q73626684-46D7830E-8587-41C3-98FF-3823F55F83B5 wds:Q73626684-8C7A0D54-44C1-4E88-BF63-02AE3D373115 wds:Q73626684-8E3A34D9-BDA0-4131-97D4-4A7E6FB65C48 wds:Q73626684-93E4E14F-9F6F-4E51-A41F-BFFF3D4E079B wds:Q73626684-988A06E9-C6DF-4B5E-99AC-71606032CA7F wds:Q73626684-9B329503-D265-4CD8-9414-5D4594ED1688 wds:Q73626684-9BD68C79-EB99-4E39-8E92-0E3E1437E5C8 wds:Q73626684-9DB034A4-EA03-454C-AE1F-DB9132952550 wds:Q73626684-D81C87C9-5A41-43B7-A13D-15A235C2C4C6
author name string	H Yssel W Friedrich K Schwarz M Steinberg N Taylor C Rebouissou K Bacon N Noraz R Hipskind V Dardalhon
rdfs:label	Alternative antigen receptor (nl) Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-deficient patients expressing high levels of Syk (en)
skos:prefLabel	Alternative antigen receptor (nl)

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