About: Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits

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About: Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits Goto Sponge NotDistinct Permalink

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scientific article published on 01 August 1997

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в серпні 1997 (uk) im August 1997 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'agostu de 1997 (ast) scientific article published on 01 August 1997 (en)
publication date	wds:Q73589806-36485B7F-26AB-47C8-B767-8A6CAA060445
publication date	1997-08-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73589806-5B7D1FA3-216F-42FE-ADAF-EE50FDF32AFD
language of work or name	English
author name string	wds:Q73589806-17841CCA-126A-4EE7-BF29-DDB1713420C1 wds:Q73589806-1A384C73-13A4-42E8-8961-78F6CA64A02C wds:Q73589806-2C5DC888-F20E-4317-A441-75825DC1928A wds:Q73589806-3966F576-079E-4B82-BE47-7303D3CF90F1 wds:Q73589806-446E9EBE-5D36-4FBB-8D95-5FAC7E6C4520 wds:Q73589806-4BC65580-5811-44C7-A23F-9BE8F3CCDE29 wds:Q73589806-4EF012FD-1193-4340-BB42-C598B17DFF4E wds:Q73589806-5D349A5A-85AF-4A05-B6DA-A5FAA0FBC783 wds:Q73589806-6EB3E046-8EFA-4DF3-BB3E-E849823F2C0C wds:Q73589806-9FBC8D86-06D6-421B-936C-B2A2B8E202D8 wds:Q73589806-A8387994-7EED-4B1B-86A0-A7B2A2EA55ED wds:Q73589806-B0FBCBC3-3430-45A8-A1DD-5272032A6A65 wds:Q73589806-C092307F-B5E9-4B10-AE8E-D744B35714C7 wds:Q73589806-D7625365-E031-43BC-BBD3-F9AE56B022F5 wds:Q73589806-D88519BF-F648-4B6E-BE10-3CD9EB94FEA3 wds:Q73589806-F06485AB-2B58-4797-BAA9-397796F85843 wds:Q73589806-FC6BFE71-CC8A-4317-AFBE-0AD5D171BAB2 wds:Q73589806-FD4F2DBB-0FB1-4DA1-BA71-2C49BBD7836E
author name string	Zhu L Wilson D Carroll BJ Hu S Goldstein R O'Byrne EM Bayburt EK Goldberg RL Blancuzzi V Ganu V MacPherson LJ Parker DT Spirito S Fryer L Melton RA Capparelli MP Doughty JR Justice MR
rdfs:label	Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits (en) Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits (nl)
skos:prefLabel	Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits (en) Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits (nl)
name	Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits (en) Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits (nl)
title	wds:Q73589806-B7D01140-A07C-423A-8F17-7F461E4CA587
title	Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits (en)
page(s)	wds:Q73589806-CB57E9CD-611E-459E-8F98-D13697FA8B31
page(s)	2525-2532
instance of	wds:Q73589806-80870E95-4A33-406A-AF2F-6671B81049A2
instance of	scholarly article
PubMed ID	wds:Q73589806-5F6FE3FB-5D89-4A02-8D4A-A6912647E738
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9258358
PubMed ID	9258358
published in	wds:Q73589806-B59DC852-27D7-45AF-BA8D-EF5EF55EF1E4
published in	Journal of Medicinal Chemistry
issue	wds:Q73589806-EC237A33-2F6C-4E02-B45A-BC2552DEE15B
volume	wds:Q73589806-105CEFAC-1A8A-4042-80A2-05995A78D1C0
issue	16
volume	40
DOI	wds:Q73589806-52C95318-828C-4A83-AAAD-C74A7F286345
DOI	http://dx.doi.org/10.1021/JM960871C
DOI	10.1021/JM960871C
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73589806
is cites work of	The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a PUTATIVE mechanism of postsynaptic plasticity The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease NAHA, a novel hydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Investigating the selectivity of metalloenzyme inhibitors Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model Protease inhibitors and their peptidomimetic derivatives as potential drugs Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors Selection of anti-sulfadimidine specific ScFvs from a hybridoma cell by eukaryotic ribosome display Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain Effects of novel semiselective matrix metalloproteinase inhibitors on ex vivo cardiac structure-function Metalloprotease inhibitor blocks angiotensin II-induced migration through inhibition of epidermal growth factor receptor transactivation Highly water-soluble matrix metalloproteinases inhibitors and their effects in a rat adjuvant-induced arthritis model The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups A profiling platform for the identification of selective metalloprotease inhibitors The synthesis and biological activity of a novel series of diazepine MMP inhibitors Target molecules for anti-angiogenic therapy: from basic research to clinical trials Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: implications for capillary basement membrane pathology Molecular imaging in cancer treatment Synthesis, biodistribution and micro-PET imaging of a potential cancer biomarker carbon-11 labeled MMP inhibitor (2R)-2-[[4-(6-fluorohex-1-ynyl)phenyl]sulfonylamino]-3-methylbutyric acid [11C]methyl ester Synthesis and preliminary biological evaluation of MMP inhibitor radiotracers [11C]methyl-halo-CGS 27023A analogs, new potential PET breast cancer imaging agents. Potent and selective aggrecanase inhibitors containing cyclic P1 substituents Comparative studies of potential cancer biomarkers carbon-11 labeled MMP inhibitors (S)-2-(4'-[11C]methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid and N-hydroxy-(R)-2-[[(4'-[11C]methoxyphenyl)sulfonyl]benzylamino]-3-methylbutanamide Tumor angiogenesis as a therapeutic target

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