About: Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation

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About: Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation Goto Sponge NotDistinct Permalink

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scientific article published on 01 December 2000

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в грудні 2000 (uk) مقالة علمية تنشرت ف 1 دجنبر 2000 (ary) artículu científicu espublizáu n'avientu de 2000 (ast) scientific article published on 01 December 2000 (en) im Dezember 2000 veröffentlicher wissenschaftlicher Artikel (de)
publication date	wds:Q73342628-79C091D4-6E34-4DB5-B11F-F51850586BE7
publication date	2000-12-01 00:00:00Z (xsd:dateTime)
cites work	wds:Q73342628-00C76923-A640-41D9-8368-8C41D1AB7852 wds:Q73342628-01C9ADF1-33DB-4F3E-AD09-C37995074B9D wds:Q73342628-0B7DE261-9F4B-4EA8-BC62-DE7D64F5881F wds:Q73342628-13E0E92F-A885-41E0-ABFD-B48A01EB40AC wds:Q73342628-278265C8-16FC-4AF9-A1C9-7DFCAB54D22C wds:Q73342628-2F255FBE-84E2-47FC-8E0E-09E4306DECBA wds:Q73342628-2FC7A0D9-1A15-41C5-84DC-83E09535C2DC wds:Q73342628-34DC2EAA-43B1-4B02-84A2-49F45CB5D350 wds:Q73342628-37F37139-03EB-4F97-92AB-6AB55ECA026E wds:Q73342628-3E02164C-23D8-4728-BD47-B61013009717 wds:Q73342628-43C52803-58EB-46AD-B4C6-79BF21D90C69 wds:Q73342628-482D1001-7021-4101-8DF1-51850798670C wds:Q73342628-66B7F398-E667-432E-8B63-21B57409F36F wds:Q73342628-6AE45BBF-251E-4A6F-BB26-2555803B471D wds:Q73342628-6B5850E6-0C79-4A65-A5AC-225DA8CD4CED wds:Q73342628-6BD7ECD0-0BA7-499E-852D-975D4A09F0EF wds:Q73342628-93BBE8DE-4F18-4195-9FC4-892EE1346B33 wds:Q73342628-9CCEA9A0-4294-4855-90D4-0C620E8B4A30 wds:Q73342628-A1B70664-C851-4344-AA8A-C8F516237653 wds:Q73342628-AC339354-10DF-4146-AD9D-C67DDA6E1730 wds:Q73342628-B3603CEC-8644-4E83-AFA5-207E7FA6A05A wds:Q73342628-BDD00D28-C3C9-4A27-85C3-054CB704DEA5 wds:Q73342628-C17CF1D4-D784-4695-82AB-C7FB714D9389 wds:Q73342628-CDDB4FD2-B7BE-4999-B39A-095A2531FE00 wds:Q73342628-D0680CA2-104E-4690-8A7A-44A746EDDAE6 wds:Q73342628-D5C8BB21-7F11-477A-9B66-C49A75FA5312 wds:Q73342628-DA468B30-DE2E-4CCB-AB6A-B39F50B7569E wds:Q73342628-DD6EB2DC-A6AB-41A9-9267-25D032822A1A wds:Q73342628-F53EE3D3-DC3A-4FDA-A064-23CE5708FCCB
cites work	Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues Glutathione Comparison of the short-term effects of di(2-ethylhexyl) phthalate, di(n-hexyl) phthalate, and di(n-octyl) phthalate in rats The Role of Active Metabolites in Drug Toxicity Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine A fluorometric method for determination of oxidized and reduced glutathione in tissues Resistance of precision-cut liver slices to the toxic effects of menadione. Importance and regulation of hepatic glutathione Biliary excretion of glutathione and glutathione disulfide in the rat. Regulation and response to oxidative stress Glutathione biosynthesis; gamma-glutamylcysteine synthetase from rat kidney Circadian periodicity of tissue glutathione and its relationship with lipid peroxidation in rats Glutathione metabolism and its role in hepatotoxicity Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil Effect of BCNU pretreatment on diquat-induced oxidant stress and hepatotoxicity. Glutathione and lipid peroxide levels in rat liver following administration of methapyrilene and analogs. Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology Characterization of the hepatic responses to the short-term administration of ciprofibrate in several rat strain. Co-induction of microsomal cytochrome P-450 IVA1 and peroxisome proliferation Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats. Thiophene sulfoxides as reactive metabolites: formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo. Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid Ultrastructural changes in the liver of animals treated with methapyrilene and some analogs. Thiophene S-oxides as new reactive metabolites: formation by cytochrome P-450 dependent oxidation and reaction with nucleophiles Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione Relationship between peroxisome-proliferating sulfur-substituted fatty acid analogs, hepatic lipid peroxidation and hydrogen peroxide metabolism The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat
author name string	wds:Q73342628-08D4DDC5-3A97-43D9-8BCF-71A9A10C69A2 wds:Q73342628-3B8D7577-E89E-421A-8B02-6280D822A1EE wds:Q73342628-55A637B6-AEF4-4CE0-BFFA-6A4CF27A40D9 wds:Q73342628-9A55B9C4-DC99-4EBB-9792-FF4086C85A7E wds:Q73342628-9BD6B1CD-957C-49CC-805B-2F32A63037D1
author name string	B K Park C J Powell S Cottrell J L Maggs G S Ratra
rdfs:label	Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation (en) Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation (nl)
skos:prefLabel	Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation (en) Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation (nl)
name	Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation (en) Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation (nl)
title	wds:Q73342628-F0370249-C685-411C-A923-7E7490D30F16
title	Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation (en)
page(s)	wds:Q73342628-39D5EA8B-1494-4A6A-B7B8-8F8613EF363A
page(s)	279-295
instance of	wds:Q73342628-643B89FB-F317-4DAC-9EE5-67C019D864A1
instance of	scholarly article
main subject	wds:Q73342628-A77B019E-0588-4398-B0B3-9FDF408A1967 wds:Q73342628-C6DD3384-5768-4F6E-8E5F-E74C69CF2851
main subject	glutathione methapyrilene
PubMed ID	wds:Q73342628-C753A5ED-4AD3-4716-B297-91029FD969C5
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11137066
PubMed ID	11137066
published in	wds:Q73342628-E5D1E6E3-0E3A-4620-8C8C-7330D6C7D511
published in	Chemico-biological Interactions
issue	wds:Q73342628-BE248BEB-232F-431B-9734-BECC100F93FF
volume	wds:Q73342628-473002E9-1B43-49C8-AC42-41E457B8C7D6

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