About: Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes

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About: Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes Goto Sponge NotDistinct Permalink

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scientific article published on 01 October 1999

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в жовтні 1999 (uk) article scientifique publié en 1999 (fr) im Oktober 1999 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'ochobre de 1999 (ast) scientific article published on 01 October 1999 (en)
publication date	wds:Q73066446-B7EC46B2-4EF9-4894-9E6A-237FB3F82081
publication date	1999-10-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73066446-D2CE1897-0EA0-4487-B7B6-F3CD65555712
language of work or name	English
cites work	wds:Q73066446-008B8BE5-9244-4BF6-B4F0-E400DFB332F1 wds:Q73066446-10DBF465-8877-47B8-9C7F-0A0EA14BC417 wds:Q73066446-3C901EAA-1C9C-4943-BF88-FC0B6E80CC92 wds:Q73066446-4A948E12-A220-4EFA-A7FA-BC779394E1DC wds:Q73066446-51CEAF35-4348-413E-A2E4-78649BB112BE wds:Q73066446-57DDABF3-A999-4EFD-BDFC-4C2BF2C17E3E wds:Q73066446-6B71BE40-53C4-4190-BD4D-8FFA5FFC0E63 wds:Q73066446-7157C7EE-BB7F-494F-B5FE-6381642D0A03 wds:Q73066446-975BB7D3-0F71-42C5-B6AD-B6A37835FC95 wds:Q73066446-C2E87C3E-25FF-4BAF-9D1A-748747F9D37A wds:Q73066446-CA6536ED-1F0A-4131-8D2C-DD9B511D583E wds:Q73066446-CAC08A40-9BC7-4EA1-A5F0-057AC6597FB6 wds:Q73066446-D716C876-6897-431B-AF6B-9070F2DE23D3
cites work	Ideal copolymers and the second-order transitions of synthetic rubbers. i. non-crystalline copolymers Characteristics and significance of the amorphous state in pharmaceutical systems Formation of glasses from liquids and biopolymers Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures Spontaneous degradation of polypeptides at aspartyl and asparaginyl residues: effects of the solvent dielectric Chemical pathways of peptide degradation. II. Kinetics of deamidation of an asparaginyl residue in a model hexapeptide The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids Effect of high molecular mobility of poly(vinyl alcohol) on protein stability of lyophilized gamma-globulin formulations How does residual water affect the solid-state degradation of drugs in the amorphous state? Moisture-induced aggregation of lyophilized insulin Calcium affects the spontaneous degradation of aspartyl/asparaginyl residues in calmodulin. The use of solution theories for predicting water vapor absorption by amorphous pharmaceutical solids: a test of the Flory-Huggins and Vrentas models Solid-state stability of human insulin. I. Mechanism and the effect of water on the kinetics of degradation in lyophiles from pH 2-5 solutions
author name string	wds:Q73066446-21535D44-D208-4D2E-8B32-04C776B96FAC wds:Q73066446-246C89A6-D7AA-4A16-AC1A-B9757772AF35 wds:Q73066446-3DB7E6CD-91F1-41CD-95C5-2BDB65076753 wds:Q73066446-BA524337-96CB-4D94-AE80-8491E9A0A17B wds:Q73066446-E9B41377-22EF-4731-937F-7059A73DFE85
author name string	R T Borchardt E M Topp M J Hageman R L Schowen M C Lai
rdfs:label	Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly (nl) Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes (en)
skos:prefLabel	Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly (nl) Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes (en)
name	Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly (nl) Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes (en)
title	wds:Q73066446-DC5909EF-2C47-4106-BF64-2A20B95E6CE4
title	Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes (en)
page(s)	wds:Q73066446-FDBECE3C-9C4D-4FB7-8F64-08F1B962891F
page(s)	1073-1080
instance of	wds:Q73066446-F04E8EC1-7B1A-42AD-AB59-2DB251FF44F8
instance of	scholarly article
PubMed ID	wds:Q73066446-DBBC4BEB-BD95-4578-A811-EC2EC4BFCECC
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10514358
PubMed ID	10514358
published in	wds:Q73066446-D20D8FE0-D474-4B68-94AE-67A56026E191
published in	Journal of Pharmaceutical Sciences
issue	wds:Q73066446-AE15C25E-7BCD-4E16-B6E9-59F1FB800980
volume	wds:Q73066446-CD58B132-A0B7-432E-975D-7272517B1A0D
issue	10
volume	88
DOI	wds:Q73066446-3546BE43-B886-42C0-A9A5-30434FF3F515
DOI	http://dx.doi.org/10.1021/JS980227G
DOI	10.1021/JS980227G
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73066446
is cites work of	Effects of glycosylation on the stability of protein pharmaceuticals Distribution and effect of water content on molecular mobility in poly(vinylpyrrolidone) glasses: a molecular dynamics simulation. The role of thiols and disulfides on protein stability. Effect of viscosity on the deamidation rate of a model Asn-hexapeptide In vivo release kinetics of octreotide acetate from experimental polymeric microsphere formulations using oil/water and oil/oil processes Chemical stability of peptides in polymers. 2. Discriminating between solvent and plasticizing effects of water on peptide deamidation in poly(vinylpyrrolidone). Chemical reactivity in solid-state pharmaceuticals: formulation implications Kinetics and mechanisms of deamidation and covalent amide-linked adduct formation in amorphous lyophiles of a model asparagine-containing Peptide Coupling between chemical reactivity and structural relaxation in pharmaceutical glasses Water and solids mobility in foods Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state Effects of solution polarity and viscosity on peptide deamidation Inhibition of peptide acylation in PLGA microspheres with water-soluble divalent cationic salts Usefulness of the Kohlrausch-Williams-Watts stretched exponential function to describe protein aggregation in lyophilized formulations and the temperature dependence near the glass transition temperature. Temperature dependence of bimolecular reactions associated with molecular mobility in lyophilized formulations Improved protocol and data analysis for accelerated shelf-life estimation of solid dosage forms Effect of Water on the Chemical Stability of Amorphous Pharmaceuticals: 2. Deamidation of Peptides and Proteins Diffusion of short chain alcohols from amorphous maltose-water mixtures above and below their glass transition temperature Spontaneous formation of nanoparticles on electrospun nanofibres
is cites work of	wds:Q42020795-0BE63F0B-102A-4960-B271-432D5C2B5B5C wds:Q37361931-4F3A83ED-9776-45A1-BB53-03D5DA5F783F wds:Q42542049-1F6F3190-69BE-4984-8302-DE67573DDBD7 wds:Q37114305-2CBC8B16-A922-4DBE-B2AD-72A94936D853 wds:Q46563123-A5953A53-8D8A-40B1-8CF6-5088BA9B8A9C wds:Q30616703-54AFD9C3-CCA2-461F-B4D9-CE9A7B7CF7DC wds:Q43967461-5A34CE38-13C9-4DAF-B063-89FC07160D1E wds:Q73233594-19CF783B-D718-4CCB-8D45-D63395B4C022 wds:Q52142573-929D710D-EBA4-413D-9563-640725989CE6

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