About: Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS)

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS) Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

scientific article published on 01 August 2000

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в серпні 2000 (uk) im August 2000 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'agostu de 2000 (ast) scientific article published on 01 August 2000 (en)
publication date	wds:Q72995250-96BB4481-1938-464F-BFD3-5010DAD31D69
publication date	2000-08-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q72995250-E4FF7FE2-4E87-4062-8707-B014BFB9EAFC
language of work or name	English
cites work	wds:Q72995250-03D6334B-4155-4230-99A4-B12D4ECDDA2C wds:Q72995250-0838E09E-AF35-4941-8BE1-9E0A9C944DCF wds:Q72995250-09BE04CA-832F-4C44-A171-637B1151E64F wds:Q72995250-0D2A1376-4305-4A15-B151-9E201116ACD7 wds:Q72995250-1A6C5B54-A3B8-461E-9B99-6D98FB79FA4F wds:Q72995250-381B0289-9866-4350-BEC7-4CB915C3B61E wds:Q72995250-472A1597-B0EA-497B-B21E-38E1A553DCC2 wds:Q72995250-4E3C59B3-36D4-43AE-9A0B-67AF208D24D9 wds:Q72995250-633C48A1-A3CE-4CFD-B078-F8C8EBEF50E6 wds:Q72995250-7CA6C1B8-FF91-450E-96A8-E8DA0813BB4D wds:Q72995250-8EFCFBDD-DC93-4E6A-BBE7-086CC8F09E5D wds:Q72995250-92D1AFB9-2469-4097-B4A0-04F81382AA1D wds:Q72995250-B832EF63-BA45-4030-92B3-F37CC625047C wds:Q72995250-CA0ADB78-3681-48EA-8FC6-1998C77801A5 wds:Q72995250-CB380BB6-97BC-4E8C-8231-4FC0B434124A wds:Q72995250-E2565B51-F611-4D19-803D-23BB6E1A22D0 wds:Q72995250-F64D24AB-8582-4981-A571-30361788B6C3 wds:Q72995250-F8DC62E9-C78A-478F-9672-4B6B8694DD33
cites work	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine in combination with cyclophosphamide: an active, low-toxicity regimen for metastatic hormonally unresponsive prostate cancer Microsomal epoxide hydrolase of rat liver is a subunit of theanti-oestrogen-binding site Mechanisms of growth inhibition by nonsteroidal antioestrogens in human breast cancer cells Variation of the inhibition of calmodulin dependent cyclic AMP phosphodiesterase amongst analogues of tamoxifen; correlations with cytotoxicity Comparative affinity of steroidal and non-steroidal antioestrogens, cholesterol derivatives and compounds with a dialkylamino side chain for the rat liver antioestrogen binding site. Differential Initiation of Translation of a Single Estrogen Receptor mRNA Could Explain Some Estradiol Resistance Cases A diphenylmethane derivative selective for the anti-estrogen binding site may help define its biological role Structure-activity relationship of antiestrogens. Studies on 2,3-diaryl-1-benzopyrans Physicochemical and genetic evidence for specific antiestrogen binding sites Results of a clinical trial in humans with refractory cancer of the intracellular histamine antagonist, N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl, in combination with various single antineoplastic agents Synthesis of 2-(p-chlorobenzyl)-3-aryl-6-methoxybenzofurans as selective ligands for antiestrogen-binding sites. Effects on cell proliferation and cholesterol synthesis Modifications of benzylphenoxy ethanamine antiestrogen molecules: influence affinity for antiestrogen binding site (AEBS) and cell cytotoxicity Antagonism of estrogen receptor and calmodulin association by antiestrogens is not dependent on an interaction with calmodulin Phase II trial of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine.HCl and doxorubicin chemotherapy in metastatic breast cancer: A National Cancer Institute of Canada clinical trials group study Ligands of the antiestrogen binding site block endothelial cell proliferation reversibly The intracellular histamine antagonist, N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethamine.HCL, may potentiate doxorubicin in the treatment of metastatic breast cancer: Results of a pilot study
author name string	wds:Q72995250-0AC584E4-ED93-46CD-8C0C-26E8242933A5 wds:Q72995250-16729C76-DE79-4034-A372-A264F0CB3E8C wds:Q72995250-3AD294E6-9649-4FED-B901-BF3EC3A4F42F wds:Q72995250-74AFF432-384B-4DFB-9D01-F63C475DC167 wds:Q72995250-E3C45D2C-10E3-4D87-9CAB-F66E11101333 wds:Q72995250-E85EA7BE-D73F-4E06-A604-BD2FBB0F5BE4
author name string	J C Faye F Delarue J J Perie M Poirot A Klaebe P De Medina
rdfs:label	Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS) (en) Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS) (nl)
skos:prefLabel	Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS) (en) Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS) (nl)
name	Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS) (en) Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS) (nl)
title	wds:Q72995250-176C7E29-77F6-4B75-9506-F17382347324
title	Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS) (en)
page(s)	wds:Q72995250-974DDE73-BA8C-4B96-B238-1B725BDC19AC
page(s)	2007-2016
instance of	wds:Q72995250-C44C3807-3A07-4759-9F55-65CDBF65F4C2
instance of	scholarly article
PubMed ID	wds:Q72995250-A8FB9DFB-F90F-4634-8EA0-52DCFE0AE644
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11003145
PubMed ID	11003145
published in	wds:Q72995250-2DA7DF6A-8F18-4741-A697-CA99C4F6161E
published in	Bioorganic & Medicinal Chemistry
issue	wds:Q72995250-A487C153-D8D1-4B38-A505-C39E82FE8423
volume	wds:Q72995250-35F2072C-42EF-41CB-9C03-71F50187B8C6
issue	8
volume	8
DOI	wds:Q72995250-D8E4C369-F1BE-4E38-BD2B-FF1B3D8BEFE6
DOI	http://dx.doi.org/10.1016/S0968-0896(00)00119-X
DOI	10.1016/S0968-0896(00)00119-X
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q72995250
is cites work of	Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways. Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor. Dendrogenin A drives LXR to trigger lethal autophagy in cancers. Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds.
is cites work of	wds:Q34068091-ADCB2568-E9C6-4AD7-8731-F928C7DAFA36 wds:Q47594502-5D465477-BD07-4242-9A90-D60D807D7E8B wds:Q37132250-336B2DE0-20ED-4A7C-BC83-98E64662FD7C wds:Q39839020-27F3E5DC-FB54-4A4C-BF22-9B120C5F8AE6 wds:Q36427475-BD67402E-F673-4A75-9603-913D122B0407 wds:Q25257588-EA0CFC1E-D4E0-4B0D-B51D-FAE48EF02D7D wds:Q47107657-FD3D3909-3DE1-4296-8B50-4AFB7F2C5FF7

Faceted Search & Find service v1.16.117 as of May 05 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of May 5 2024, on Linux (x86_64-centos_6-linux-gnu), Single-Server Edition (378 GB total memory, 195 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software