About: Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations

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About: Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations Goto Sponge NotDistinct Permalink

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scientific article published on 01 November 1993

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в листопаді 1993 (uk) article scientifique publié en 1993 (fr) im November 1993 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en payares de 1993 (ast) scientific article published on 01 November 1993 (en)
publication date	wds:Q72641388-A207F025-4BC9-41AA-A38E-6CCCF1144AEE
publication date	1993-11-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q72641388-021396ED-3DC5-4266-930B-218C448D7589
language of work or name	English
cites work	wds:Q72641388-73A03965-048B-40A0-9CBE-0A06CE604B2C
cites work	Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity
author name string	wds:Q72641388-0B3C0B34-89C9-4D9F-A0FF-242A47EA938A wds:Q72641388-10B30E80-6E58-49DD-9BF2-AADB9A9659C7 wds:Q72641388-342E1FC9-B2DE-4E3D-8D99-31E2B56A2D7F wds:Q72641388-63F2D5AD-9914-4861-8219-ECD551ED4C50 wds:Q72641388-71A360A3-CC65-404E-A48E-DCFE76282E68 wds:Q72641388-B129A71A-EF88-4130-9558-D594D8F6DAF9
author name string	B Testa W F van Gunsteren N el Tayar R M Brunne A E Mark P Vallat
rdfs:label	Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations (en) Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations (nl)
skos:prefLabel	Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations (en) Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations (nl)
name	Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations (en) Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations (nl)
title	wds:Q72641388-E0EAF1C9-F982-4424-AC65-1A902371BE25
title	Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations (en)
page(s)	wds:Q72641388-6B6B9B79-A36F-4B0D-BDAF-3CA98587D746
page(s)	3757-3764
instance of	wds:Q72641388-6EABC0AD-6502-41DE-B34E-33EC6D790548
instance of	scholarly article
main subject	wds:Q72641388-875B2B84-D7C8-4812-8CE3-99AECCA4202F
main subject	cyclosporine
PubMed ID	wds:Q72641388-6EF3AC70-765F-4853-B5D1-5A215EDB4C55
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8254605
PubMed ID	8254605
published in	wds:Q72641388-AB44202F-6027-4B59-AD90-C6C8AA42A289
published in	Journal of Medicinal Chemistry
issue	wds:Q72641388-F514D629-0920-484A-BFAF-0F293F1D0E4F
volume	wds:Q72641388-F13B3ADD-DFC0-49EB-9AA0-3180FA87D6D4
issue	24
volume	36
DOI	wds:Q72641388-A2FED501-7F35-4820-8524-9C38437E8A73
DOI	http://dx.doi.org/10.1021/JM00076A002
DOI	10.1021/JM00076A002
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q72641388
is cites work of	A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporine Novel formulations for antimicrobial peptides Cyclosporine A delivery to the eye: A pharmaceutical challenge Oral cyclosporine A--the current picture of its liposomal and other delivery systems. 1H and 13C-NMR and molecular dynamics studies of cyclosporin a interacting with magnesium(II) or cerium(III) in acetonitrile. Conformational changes and cis-trans conversion of peptide bonds Modulation of P-glycoprotein activity in Calu-3 cells using steroids and beta-ligands Estimation of the increase in solubility of drugs as a function of bile salt concentration. High-throughput evaluation of relative cell permeability between peptoids and peptides Chromatographic retention of drug molecules on immobilised liposomes prepared from egg phospholipids and from chemically pure phospholipids Safety and efficacy of cyclosporine in the treatment of chronic dry eye. Strategies toward predicting peptide cellular permeability from computed molecular descriptors. Clinical studies with oral lipid based formulations of poorly soluble compounds Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties. Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs. The effect of environment on the stability of an integral membrane helix: Molecular dynamics simulations of surfactant protein C in chloroform, methanol and water A study of the binding requirements of calyculin A and dephosphonocalyculin A with PP1, development of a molecular recognition model for the binding interactions of the okadaic acid class of compounds with PP1. The effect of conformation of the acyloxyalkoxy-based cyclic prodrugs of opioid peptides on their membrane permeability Solubilization of cyclosporin A. Engineering β-sheets employing N-methylated heterochiral amino acids. Octanol-water partition of nonzwitterionic peptides: predictive power of a molecular size-based model. Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of the supercritical antisolvent process with the conventional film method Short term effects of topical cyclosporine and viscoelastic on the ocular surfaces in patients with dry eye Structure-lipophilicity relationships of peptides and peptidomimetics Peptidic Macrocycles - Conformational Sampling and Thermodynamic Characterization. An overview on dry eye treatment: approaches for cyclosporin a delivery Relation between retention factors of immunosuppressive drugs in microemulsion electrokinetic chromatography with biosurfactants and octanol-water partition coefficients. New agents for treating dry eye syndrome. Formulation and evaluation of a protein-loaded solid dispersions by non-destructive methods Controlled ocular drug delivery with nanomicelles Production and characterization of 22 monoclonal antibodies directed against S 20499, a new potent 5-HT1A chiral agonist: influence of the hapten structure on specificity and stereorecognition A New Hydrate of Cyclosporine: Structural and Physicochemical Characterization The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration Stability of a second-generation cephalosporin veterinary mastitis formulation after electron beam irradiation Cyclosporine Amicellar delivery system for dry eyes Molecules as complex adaptative systems: constrained molecular properties and their biochemical significance Nano composite emulsion for sustained drug release and improved bioavailability 11-Demethylcyclosporins exhibit a single conformation in methanol and dimethylsulfoxide Understanding and designing head-to-tail cyclic peptides Analytical method for monitoring concentrations of cyclosporin and lovastatin in vitro in an everted rat intestinal sac absorption model Solubilization of Cyclosporine in Topical Ophthalmic Formulations: Preformulation Risk Assessment on a New Solid Form Cyclosporin absorption is impaired by the fat substitutes, sucrose polyester and tricarballylate triester, in the rat Prediction of Passive Membrane Permeability by Semi-Empirical Method Considering Viscous and Inertial Resistances and Different Rates of Conformational Change and Diffusion
is cites work of	wds:Q26991771-22F183C2-D28B-4754-B883-97DA9A80668E wds:Q43511616-FE26CF56-9383-442C-832B-DA3BEBEE5FFB wds:Q40778082-8D5652D2-AD5A-4CF8-B27C-CA30169435B8 wds:Q42014153-B1031CA0-45F5-4DB9-B189-3C5D1DFF5BDB wds:Q44731611-F465FA38-6D9C-4046-B8BF-AD18A8BFA38C wds:Q51583931-24A53888-8DBF-4CB5-A820-E7C058B403B1

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