About: Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones

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About: Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones Goto Sponge NotDistinct Permalink

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scientific article published on 01 July 1994

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в липні 1994 (uk) article scientifique publié en 1994 (fr) im Juli 1994 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xunetu de 1994 (ast) scientific article published on 01 July 1994 (en)
publication date	wds:Q72114635-A4A5663C-4DB9-46D1-A72C-80A9A21CF041
publication date	1994-07-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q72114635-AE636F07-E904-4A4D-B34D-49A0BF41355E
language of work or name	English
author name string	wds:Q72114635-2873AE32-4ED3-4D4B-8893-9B237480FD15 wds:Q72114635-5FA4A002-75EC-4625-B09B-8EB9CBAD5087 wds:Q72114635-7BDC820D-3C4D-461B-9E29-D917D294B905 wds:Q72114635-7DB0DC90-1B78-4141-935F-3454B99EA85F wds:Q72114635-8FEC16D4-F92C-414A-AAA9-28F8D92D3D86 wds:Q72114635-9317F3B6-6AB4-440B-AB55-7DBD4265B865 wds:Q72114635-A6661D61-1A79-4E24-B1BB-E6418B80707A
author name string	A C Sartorelli T S Lin A H Cory J G Cory M C Liu A Lorico G Rappa
rdfs:label	Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones (en) Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones (nl)
skos:prefLabel	Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones (en) Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones (nl)
name	Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones (en) Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones (nl)
title	wds:Q72114635-BB2A7D13-19D2-4148-AF68-72D8945F1E83
title	Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones (en)
page(s)	wds:Q72114635-5AAA8AE8-8440-40A2-8344-9330A9A8AF30
page(s)	335-344
instance of	wds:Q72114635-95089B28-E058-48C9-8563-96AE70A836F3
instance of	scholarly article
PubMed ID	wds:Q72114635-073C34E1-B81D-4E8A-84C6-E5E1ACFB4E2A
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8053929
PubMed ID	8053929
published in	wds:Q72114635-96C7594D-9505-471C-A99E-9EA06EEBB495
published in	Biochemical Pharmacology
issue	wds:Q72114635-4DDECA02-2B4B-4BA9-9E79-4DF009B578CB
volume	wds:Q72114635-41FEB2F8-A011-4067-A733-C3E4615C9E04
issue	2
volume	48
DOI	wds:Q72114635-99D08B86-96BA-4177-8706-56507C998A22
DOI	http://dx.doi.org/10.1016/0006-2952(94)90105-8
DOI	10.1016/0006-2952(94)90105-8
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q72114635
is cites work of	Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas Phase II study of Triapine in patients with metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC IND.161) Population pharmacokinetics of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine®) in cancer patients Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies Iron chelators as therapeutic agents for the treatment of cancer. Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity. Phase II trial of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehydethiosemicarbazone plus gemcitabine in patients with advanced biliary tract cancer A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase Platinum(II) and palladium(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone as alternative antiherpes simplex virus agents Turning tumor-promoting copper into an anti-cancer weapon via high-throughput chemistry Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer A phase I study of Triapine in combination with doxorubicin in patients with advanced solid tumors A phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive mye Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase Phase I study of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) in combination with high dose cytarabine in patients with advanced myeloid leukemia. Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo Neuroprotective activity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (PAN-811), a cancer therapeutic agent. Targeting cancer by binding iron: Dissecting cellular signaling pathways A phase II trial of sequential ribonucleotide reductase inhibition in aggressive myeloproliferative neoplasms Cellular delivery of nucleoside diphosphates: a prodrug approach ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. Antibacterial, antifungal and in vitro antileukaemia activity of metal complexes with thiosemicarbazones. Eco-Friendly Synthesis of Some Thiosemicarbazones and Their Applications as Intermediates for 5-Arylazothiazole Disperse Dyes. Antiproliferative and cytotoxic effects of geldanamycin, cytochalasin E, suramin and thiacetazone in human prostate xenograft tumor histocultures PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats. A New Thiosemicarbazone-Based Fluorescence "Turn-on" Sensor for Zn(2+) Recognition with a Large Stokes Shift and its Application in Live Cell Imaging. Metal complexes driven from Schiff bases and semicarbazones for biomedical and allied applications: a review
is cites work of	wds:Q33402598-ADDE0E42-10F9-45EE-8E59-163C7759EB13 wds:Q36318799-DC173C3B-A16D-4D07-88E9-952AB5847B8E wds:Q35809097-6B1527B4-E81B-467D-8F3A-90D75C4480E3 wds:Q37206068-4BF4BB75-1B3C-47B7-94B9-D01CA7391455 wds:Q34750537-50B22EC7-4FBF-406D-9EF5-C7934E1F14D8 wds:Q41107359-EA58980A-FA08-447C-B938-2BEF38A51ADF wds:Q33392476-FC7DFCF0-8E9D-44FB-8E56-53D0ECB49050 wds:Q35045012-00EA80D3-DFEE-4765-85E2-A0CB5ABC9038 wds:Q34685780-259645DE-0A3D-4F5A-BE5A-34EB51D5D711 wds:Q34459006-D50D1F39-FBB0-4D7B-AE8F-0097BE2E6AE8 wds:Q38218536-F3117969-2151-48F1-A3D7-426097B0D194 wds:Q80059427-02E75EAE-458F-48D0-8E56-C7F2863C32E4 wds:Q33724511-44315C8D-5A95-45EF-95F3-0F89145B6F02 wds:Q37529964-83F3F698-006D-40E3-8A94-788A9E8491D6 wds:Q48165375-EAD4EF4E-EF55-4F15-A279-408B64D266E3 wds:Q50236797-B8F75A14-0E26-4EC1-B94F-A3673107D7FB wds:Q34671614-F359CFCE-5D29-4200-9D5E-B9FDA59D3196 wds:Q35391111-BF740FBB-826C-41CD-B6C3-E3843220AF50

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