About: Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

scientific article published on 01 November 1984

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в листопаді 1984 (uk) im November 1984 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 01 November 1984 (en) artículu científicu espublizáu en payares de 1984 (ast)
publication date	wds:Q70702408-FC3212F5-70E7-454B-87AD-AB6A831F77F1
publication date	1984-11-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q70702408-9B7072F0-E3A4-4D47-B1AB-1E8E86CDE9BC
language of work or name	English
cites work	wds:Q70702408-0A9C80DD-5467-43BB-8D58-505D24532527 wds:Q70702408-3EF08265-A568-4FAD-AC5C-B6401F3C883C wds:Q70702408-7F81E845-DBD9-4722-BC83-3FA9DD7807E4 wds:Q70702408-831BF791-ACBE-4D9B-A43E-8E97A8576956 wds:Q70702408-A161C1AB-6276-4E40-9F13-4B5CB1F439FB wds:Q70702408-B4858D22-A107-4BED-805B-ABE0347C62A6 wds:Q70702408-D813B274-B49F-4C34-8369-05AAF264C912 wds:Q70702408-E0D93CDC-8A28-4C13-AAC4-286479B4A508 wds:Q70702408-E156A6FE-5261-49E3-8406-1C93B292B5A7 wds:Q70702408-E3F6D79E-A706-424F-97AB-6AC89CAAC01A wds:Q70702408-E52E4DE9-EC83-46B0-BDD6-8FB087858E7F wds:Q70702408-F2C1AFB8-DB9D-4508-945C-B2A48C5C9E4F
cites work	Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone Polymorphic hydroxylation of Debrisoquine in man. Defective oxidation of drugs: pharmacokinetic and therapeutic implications A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. Evidence for an enzymatic defect in the 4-hydroxylation of debrisoquine by human liver A rapid method for removal of detergents from protein solution The genetic controlof bufuralol metabolisminman Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation Oxidation polymorphism has clinical relevance Bufuralol metabolism in human liver: a sensitive probe for the debrisoquine-type polymorphism of drug oxidation Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine Kinetics and metabolism of (+)-, (?)- and (�)-bufuralol
author name string	wds:Q70702408-02BFA6D3-F422-4F9C-9BDE-CFF633CBFEC6 wds:Q70702408-0EF3BDFD-AB88-4E2C-AD82-31E5808EE656 wds:Q70702408-30625BF2-977E-4533-8036-6382605F6870 wds:Q70702408-838D99EF-926F-4A86-8E45-8BFCF2DEFFA4 wds:Q70702408-8C4DB336-A155-4AA2-BE1A-E9D321661BD2 wds:Q70702408-A4389842-0F0C-4561-8B8D-DD89BCC3A946 wds:Q70702408-FA79F40E-AE72-414D-85C3-7EC38E0FD7E8
author name string	R Gasser J Gut U A Meyer P Dayer M Eichelbaum G M Robertz T Kronbach
rdfs:label	Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers (en) Characterization of a common genetic defect of cytochrome P-450 function (nl)
skos:prefLabel	Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers (en) Characterization of a common genetic defect of cytochrome P-450 function (nl)
name	Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers (en) Characterization of a common genetic defect of cytochrome P-450 function (nl)
title	wds:Q70702408-7C2CA467-F7D3-4DFE-B561-2F7A39A14D08
title	Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers (en)
page(s)	wds:Q70702408-587A2E99-01AE-4902-BD58-9EFD610EA49F
page(s)	374-380
instance of	wds:Q70702408-87E73BC1-2898-4A54-802A-217448ECFB17
instance of	scholarly article
main subject	wds:Q70702408-11AAE9F6-FCAC-4A83-9FF2-FB4B3A588436
main subject	stereoselectivity
PubMed ID	wds:Q70702408-C5835741-31F6-4110-BD4A-A9A4B2102EE0
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6508804
PubMed ID	6508804
published in	wds:Q70702408-94139FDA-DA42-4984-8247-F53DBD1976AD
published in	Biochemical and Biophysical Research Communications
issue	wds:Q70702408-6BB7CFC2-E756-4B2B-A398-85DA9F8E83E2
volume	wds:Q70702408-656487D3-A50D-48D1-85DC-1FD198305417
issue	1
volume	125
DOI	wds:Q70702408-F6D3305F-DACD-4417-ACED-BCD893A2906D
DOI	http://dx.doi.org/10.1016/S0006-291X(84)80378-2
DOI	10.1016/S0006-291X(84)80378-2
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q70702408
is cites work of	Genetic Aspects of Drug Disposition and Therapeutics Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI) Recent developments in hepatic drug oxidation. Implications for clinical pharmacokinetics Making better drugs: Decision gates in non-clinical drug development MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry Investigation of the stereoselective metabolism of praziquantel after incubation with rat liver microsomes by capillary electrophoresis and liquid chromatography-mass spectrometry High-performance liquid chromatographic assay for the simultaneous determination of tramadol and its metabolites in microsomal fractions of human liver Clinical significance of the sparteine/debrisoquine oxidation polymorphism The metabolism of tramadol by human liver microsomes Molecular basis of polymorphic drug metabolism Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers The polymorphic oxidation of beta-adrenoceptor antagonists. Clinical pharmacokinetic considerations Regioselectivity and stereoselectivity of the metabolism of the chiral quinolizidine alkaloids sparteine and pachycarpine in the rat 49 Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6 Variability in drug metabolism: importance of genetic constitution Direct enantiomeric separation of betaxolol with applications to analysis of bulk drug and biological samples Capillary electrophoresis-mass spectrometry, liquid chromatography-mass spectrometry and nanoelectrospray-mass spectrometry of praziquantel metabolites Investigation of the stereoselective in vitro metabolism of the chiral antiasthmatic/antiallergic drug flezelastine by high-performance liquid chromatography and capillary zone electrophoresis Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s Is cyclosporin A an inhibitor of drug metabolism? Stereo- and regioselectivity of hepatic oxidation in man--effect of the debrisoquine/sparteine phenotype on bufuralol hydroxylation High-performance liquid chromatographic quantitation of 4-hydroxydebrisoquine in microsomal incubates by use of silica columns, aqueous mobile phase and automated column switching Mephenytoin stereoselective elimination in the rat: III. Stereoselective time course of induction during chronic hepatic portal vein administration
is cites work of	wds:Q39422300-C7C1B3AA-1A22-49CF-8DD8-6CD56329CFF5

Faceted Search & Find service v1.16.117 as of May 05 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of May 5 2024, on Linux (x86_64-centos_6-linux-gnu), Single-Server Edition (378 GB total memory, 180 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software