About: Jian-Dong Huang

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cancer researcher

Attributes	Values
rdf:type	Item
description	forskare (sv) 연구원 (ko) 研究者 (ja) wetenschapper (nl) дослідник (uk) эрдэмтэн (mn) वैज्ञानिक (hi) изилдөөчү (ky) 研究者 (zh) cancer researcher (en)
rdfs:label	Jian-Dong Huang (en) J D Huang (nl)
skos:prefLabel	Jian-Dong Huang (en) J D Huang (nl)
name	Jian-Dong Huang (en) J D Huang (nl)
Scopus author ID	wds:Q70624280-6F56B63E-F6AB-4701-AF23-1BA4A2602667
Scopus author ID	8108660600
instance of	wds:Q70624280-1BD6F023-C60E-444E-AF33-74599BF33125
instance of	Homo sapiens
occupation	wds:Q70624280-F4D39329-AC77-4BBD-82BF-4FA0AB5C8AFD
employer	wds:Q70624280-F55A7EF9-DD99-48D9-8536-E04BF48FE1EC
on focus list of Wikimedia project	wds:Q70624280-F1285204-E28F-4241-88DF-C40666678FC9
educated at	wds:Q70624280-29D19745-31EA-44A3-8511-5495BDD506E5 wds:Q70624280-3BAC4969-95A7-48C8-B462-6E1F469A5546
occupation	researcher
employer	Frederick National Laboratory for Cancer Research
on focus list of Wikimedia project	WikiProject COVID-19
educated at	UCLA Division of Life Sciences Fudan University
ORCID iD	wds:Q70624280-2E8FADA6-E98F-4479-ACB9-B0E63CF0D893
ORCID iD	https://orcid.org/0000-0001-7531-2816
ORCID iD	0000-0001-7531-2816
ResearcherID	wds:Q70624280-13C4D306-B39E-4F80-832A-920C9373D5F0
ResearcherID	C-4277-2009
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q70624280
is author of	Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza A virus replication. The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases. Increased efficiency of oligonucleotide-mediated gene repair through slowing replication fork progression. The interplay between multiple enhancer and silencer elements defines the pattern of decapentaplegic expression. The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus. Efficient and seamless DNA recombineering using a thymidylate synthase A selection system in Escherichia coli Identification of factors influencing strand bias in oligonucleotide-mediated recombination in Escherichia coli The torso response element binds GAGA and NTF-1/Elf-1, and regulates tailless by relief of repression. Genomic instability in laminopathy-based premature aging The involvement of replication in single stranded oligonucleotide-mediated gene repair. Dissect Kif5b in nuclear positioning during myogenesis: the light chain binding domain and the autoinhibitory peptide are both indispensable. A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas Small noncoding RNA GcvB is a novel regulator of acid resistance in Escherichia coli Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics. Use of a riboswitch-controlled conditional hypomorphic mutation to uncover a role for the essential csrA gene in bacterial autoaggregation. Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region Ultrahigh resolution mass spectrometry-based metabolic characterization reveals cerebellum as a disturbed region in two animal models. Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer's disease in CRND8 mice. Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty. Stripe formation in bacterial systems with density-suppressed motility Recombinant ESAT-6-like proteins provoke protective immune responses against invasive Staphylococcus aureus disease in a murine model Identification of major histocompatibility complex class I C molecule as an attachment factor that facilitates coronavirus HKU1 spike-mediated infection. A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection. Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus. Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex Expression and characterization of a histidine-rich protein, Hpn: potential for Ni2+ storage in Helicobacter pylori. Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions. Visualizing the proteome of Escherichia coli: an efficient and versatile method for labeling chromosomal coding DNA sequences (CDSs) with fluorescent protein genes Conventional kinesin KIF5B mediates adiponectin secretion in 3T3-L1 adipocytes Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice In vitro selection of HIV-1 CRF08_BC variants resistant to reverse transcriptase inhibitors. Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detection. Inhibition of SARS coronavirus helicase by bismuth complexes. Decrease in the Generation of Amyloid-β Due to Salvianolic Acid B by Modulating BACE1 Activity. Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model. Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity A modified formulation of Huanglian-Jie-Du-Tang reduces memory impairments and β-amyloid plaques in a triple transgenic mouse model of Alzheimer's disease SARS-CoV-2 infects human neural progenitor cells and brain organoids Super-resolution imaging of a 2.5 kb non-repetitive DNA in situ in the nuclear genome using molecular beacon probes. Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma. A SIRT1-centered circuitry regulates breast cancer stemness and metastasis Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients Portable two-way riboswitches: design and engineering Modification of the RpoS network with a synthetic small RNA. Cell death caused by single-stranded oligodeoxynucleotide-mediated targeted genomic sequence modification. Live attenuated Salmonella typhimurium vaccines delivering SaEsxA and SaEsxB via type III secretion system confer protection against Staphylococcus aureus infection. Urinary Metabolomics Reveals Alterations of Aromatic Amino Acid Metabolism of Alzheimer's Disease in the Transgenic CRND8 Mice. Analysis of Kif5b expression during mouse kidney development. Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19 Single-stranded oligonucleotide-mediated gene repair in mammalian cells has a mechanism distinct from homologous recombination repair. Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin Inhibition of HBV gene expression and replication by stably expressed interferon-alpha1 via adeno-associated viral vectors. The effect of salvianolic acid B combined with laminar shear stress on TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells 'Obligate' anaerobic Salmonella strain YB1 suppresses liver tumor growth and metastasis in nude mice. Stable knockdown of Kif5b in MDCK cells leads to epithelial-mesenchymal transition. A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile Multimodal nonlinear optical microscopy reveals critical role of kinesin-1 in cartilage development. Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity. A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating A novel galactose-PEG-conjugated biodegradable copolymer is an efficient gene delivery vector for immunotherapy of hepatocellular carcinoma

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