About: Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model

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About: Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model Goto Sponge NotDistinct Permalink

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scientific article published on 01 May 1989

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 1989 (uk) artículu científicu espublizáu en mayu de 1989 (ast) scientific article published on 01 May 1989 (en) im Mai 1989 veröffentlicher wissenschaftlicher Artikel (de)
publication date	wds:Q69352939-D0EA7E33-1627-45DD-9183-5058E1889691
publication date	1989-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q69352939-4DFA95AD-B3D5-41E5-A54C-6D0E9D76810B
language of work or name	English
author name string	wds:Q69352939-34A39681-105E-4F90-ADCD-8412CEF57477 wds:Q69352939-5488D29F-B333-434C-B0C8-2FDCF6E427A9 wds:Q69352939-767C5B19-90C4-4987-827F-3B950DE5A3F3 wds:Q69352939-8BB51180-1B49-4190-ACE3-FB8692AB74B0 wds:Q69352939-91AD1A46-7B36-420D-BFF3-C0F990601E51 wds:Q69352939-BB1597A6-5BDF-4EBD-8D2F-8E90D6B0477B wds:Q69352939-BD6D18BA-7C46-4F1C-8800-7DF44828D944 wds:Q69352939-DDDDA1A7-D200-4D28-B0FB-1902B41D587C
author name string	L A Mitscher L L Shen D W Chu C S Cooper P N Sharma T Rosen T J O'Donnell A G Pernet
rdfs:label	Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model (en) Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model (nl)
skos:prefLabel	Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model (en) Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model (nl)
name	Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model (en) Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model (nl)
title	wds:Q69352939-808B346D-2F0A-4155-926C-BB7E4788BA52
title	Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model (en)
page(s)	wds:Q69352939-665C1F7A-56CE-41B3-ADAD-9135900F3BE5
page(s)	3886-3894
instance of	wds:Q69352939-028113D2-9192-48D3-874C-F1C4807F4A4C
instance of	scholarly article
PubMed ID	wds:Q69352939-D47F210B-242F-4D0B-8B2D-8BD4B1E95893
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2546585
PubMed ID	2546585
published in	wds:Q69352939-AEDE3C4D-1A46-4BB3-8084-4A1D57910497
published in	Biochemistry
issue	wds:Q69352939-A267303B-BD07-4B6A-9CAB-01A31CE8DD20
volume	wds:Q69352939-3D3A4EBA-31DF-4409-8CE6-141BDF444839
issue	9
volume	28
DOI	wds:Q69352939-92842367-784E-4655-8B4B-703EEF62DF63
DOI	http://dx.doi.org/10.1021/BI00435A039
DOI	10.1021/BI00435A039
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q69352939
is cites work of	Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase The mode of action of quinolones: The paradox in activity of low and high concentrations and activity in the anaerobic environment Mode of action of the new quinolones: New data Incidence of various gyrA mutants in 451 Staphylococcus aureus strains isolated in Japan and their susceptibilities to 10 fluoroquinolones Analysis by PCR and direct DNA sequencing of gyrA mutations associated with fluoroquinolone resistance in Enterococcus faecalis. Mechanisms of resistance to quinolones DNA gyrase, topoisomerase IV, and the 4-quinolones DNA gyrase as a drug target The DNA cleavage reaction of DNA gyrase. Comparison of stable ternary complexes formed with enoxacin and CcdB protein A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex The DNA Gyrase-Quinolone Complex Effect of aerobic and anaerobic environments on antistaphylococcal activities of five fluoroquinolones Molecular details of quinolone-DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it. Major advances in antibacterial quinolone therapy Quinolone mode of action Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities. Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases Evaluation of complexes of DNA duplexes and novel benzoxazoles or benzimidazoles by electrospray ionization mass spectrometry Antibacterial discovery and development--the failure of success? Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli Characterization of mutations in Mycobacterium smegmatis involved in resistance to fluoroquinolones. Quinolone-DNA interaction: sequence-dependent binding to single-stranded DNA reflects the interaction within the gyrase-DNA complex In vitro assays used to measure the activity of topoisomerases A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA. Transport of pefloxacin across the bacterial cytoplasmic membrane in quinolone-susceptible Staphylococcus aureus Mechanism of action of quinolones against Escherichia coli DNA gyrase New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action The fluoroquinolone antibacterial agents Discovery and development of new antibiotics: the problem of antibiotic resistance Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid 4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction Mechanism of differential activities of ofloxacin enantiomers DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli Characterization of quercetin binding site on DNA gyrase New Escherichia coli gyrA and gyrB mutations which have a graded effect on DNA supercoiling. Synthesis and in vitro antibacterial activity of some N-(5-aryl-1,3,4-thiadiazole-2-yl)piperazinyl quinolone derivatives. Synthesis and in vitro antibacterial evaluation of N-[5-(5-nitro-2-thienyl)-1,3,4-thiadiazole-2-yl] piperazinyl quinolones. Molecular basis for the differential quinolone susceptibility of mycobacterial DNA gyrase Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex Quinolone binding to DNA is mediated by magnesium ions Antibacterial activities and inhibitory effects of sitafloxacin (DU-6859a) and its optical isomers against type II topoisomerases. Correlation of quinolone MIC and inhibition of DNA, RNA, and protein synthesis and induction of the SOS response in Escherichia coli.

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