About: Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection

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About: Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection Goto Sponge NotDistinct Permalink

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description	wetenschappelijk artikel (nl) наукова стаття, опублікована в жовтні 2000 (uk) article scientifique publié en octobre 2000 (fr) im Oktober 2000 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q64380401-9574E8F1-3A19-4D02-8F15-4525737D51EE
publication date	2000-10-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q64380401-EAAABBEC-6149-4A3C-821C-635E6E2F2C71
language of work or name	English
cites work	wds:Q64380401-0E3C0124-91D7-4A1F-8E47-DB4A1F68E2BE wds:Q64380401-0FCF1B4A-BC73-4F99-8A3A-8D4D282BCDF0 wds:Q64380401-186BDF11-B7E5-4CDB-8E81-270A7C0E6C8B wds:Q64380401-19A7BF43-1927-4893-AB78-FAC730D97AF6 wds:Q64380401-1A68EFDF-5AD0-4C61-AA13-6AB2EEC32704 wds:Q64380401-1FA11909-86C1-4626-9B23-D154B31F05D2 wds:Q64380401-2AE8E60B-DE3F-4B5F-A2A8-7A391BF776C1 wds:Q64380401-2BB7C325-5BF7-4FCB-80F9-2F3C0853497A wds:Q64380401-329313B5-9421-49B7-88D8-B61B4C6A59C4 wds:Q64380401-340950A5-8ECF-4334-B71F-4F1004B60FE6 wds:Q64380401-435E7E4B-3D51-4E31-BBE0-919183BD7912 wds:Q64380401-4452E4ED-0BE6-4BA3-9889-B1DCFB8A2E73 wds:Q64380401-46B3827C-972E-4544-89DF-E5170376078A wds:Q64380401-517E1AC2-AAA6-4962-A3C1-FE852C244C22 wds:Q64380401-569CBA10-C7A3-4969-9BCA-DBBE401EC7D1 wds:Q64380401-5722A8E1-2A7B-4E78-903C-25C4A58E3574 wds:Q64380401-5A16320F-2945-4426-A1AB-4FED0AFCDEF4 wds:Q64380401-741034FC-7B8A-482C-903F-3119B2E1F511 wds:Q64380401-7470F63C-F4ED-4D8F-BB78-83F59741DEB4 wds:Q64380401-7D84EE15-6FB8-4003-8B87-4358980F3F2C wds:Q64380401-84744F7C-357D-42CD-8E10-42CBD579F206 wds:Q64380401-885DBE75-ED37-4F6A-9825-A51287BC02FC wds:Q64380401-916AC0F3-BD5E-4B4E-A50D-A7E7A3751A4D wds:Q64380401-91B56130-8A08-46D4-81F4-CE92709125D0 wds:Q64380401-99DEA910-166D-416A-9045-84F6D0F13267 wds:Q64380401-9D96EEC1-35D9-45A1-BF10-7E5670FC303C wds:Q64380401-B0179463-3FAB-4DA1-8096-E9C9F2690CFF wds:Q64380401-BD9945E9-8D20-4802-B5BB-52339E38B1F3 wds:Q64380401-C11AF0C5-7034-4949-A5C1-E8A2F4A5498D wds:Q64380401-C336C740-244E-4E7A-85D0-C9D33528FD4B wds:Q64380401-CF486DDE-2900-441D-8FA1-9D96A81170F6 wds:Q64380401-E21C56AE-8527-4E67-8506-BD192124368C wds:Q64380401-E2A7D5F1-2BE2-4E52-A1D0-3A45AFDC720E wds:Q64380401-E6EF5835-3F3F-46E3-8D8D-FF9F3DDF82CC wds:Q64380401-EA1B064D-863A-4C54-A81E-BFB61946A637 wds:Q64380401-EDAC05FD-DC50-4A3A-B1D1-C69BC653575D wds:Q64380401-F129D599-94F6-4574-A5ED-6EE2575576EA
cites work	Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance Improved technique of heart transplantation in rats Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38mapk are involved in IL-10-mediated selective repression of TNF-alpha-induced activation and maturation of human peripheral blood monocyte-derived Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis Induction of tolerance by IL-10-treated dendritic cells The dendritic cell system and its role in immunogenicity Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendriti Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1. Systemic administration of cellular interleukin-10 can exacerbate cardiac allograft rejection in mice Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset Monocyte-derived dendritic cell precursors facilitate tolerance to heart allografts after total lymphoid irradiation. Differential effects of exogenous interleukin-10 on cardiac allograft survival: inhibition of rejection by recipient pretreatment reflects impaired host accessory cell function IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells Immunotherapeutic potential of tumor antigen-pulsed and unpulsed dendritic cells generated from murine bone marrow
author name string	wds:Q64380401-05643BD6-0461-40D7-952C-92CA8C42ABF1 wds:Q64380401-07CF2D07-D495-484D-B0A8-E11BA507F91B wds:Q64380401-0A231869-8739-44FC-BEC5-8F9D3FA7D10C wds:Q64380401-2BBAA1F1-1339-4DE4-B4AF-4D15EC05E558 wds:Q64380401-371D7512-0133-483C-B18B-3006AC087E77 wds:Q64380401-479E8979-D511-4F8E-A7E5-F998907DDE4E wds:Q64380401-BF0D8635-05DC-4988-A754-98D59D09E4E9
author name string	W Li L Lu Y Wan Z Xing W C Lee J Gauldie S Qiani
rdfs:label	Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection (en) Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection (nl)
skos:prefLabel	Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection (en)

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