About: β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma

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About: β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma Goto Sponge NotDistinct Permalink

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scholarly article by Guangya Zhang et al published 15 March 2019 in Cell Death and Disease

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в березні 2019 (uk) article scientifique publié en 2019 (fr) im März 2019 veröffentlichter wissenschaftlicher Artikel (de) scholarly article by Guangya Zhang et al published 15 March 2019 in Cell Death and Disease (en)
publication date	wds:Q64086091-66C6CA86-1186-4398-AB30-5D29042831D7
publication date	2019-03-15 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q64086091-10C82456-7B2A-4ECE-806D-504832609A78
language of work or name	English
cites work	wds:Q64086091-03EAEC45-3401-41E5-AC3F-65EB128FE023 wds:Q64086091-05B5352A-43FC-49E6-8647-1124B8565417 wds:Q64086091-13222D4F-E69C-4670-B5A6-A43A27D72D72 wds:Q64086091-13412598-05C8-4915-9835-5B54DA40FEE5 wds:Q64086091-17E94D03-27B3-42AF-8C72-9D6F4829E71B wds:Q64086091-24B45C55-C796-4B57-B38E-E2B256492653 wds:Q64086091-270362D4-06F4-4438-9C2A-716C9DB1937C wds:Q64086091-4D5F7DA9-8921-4A31-BC3B-8246A589639A wds:Q64086091-4EEAEAAB-40A6-4656-A0B8-A94B0B62BDB3 wds:Q64086091-56F1F20D-E80A-401A-9974-0EDA43EC7BA5 wds:Q64086091-59372A5D-9E28-4B09-87E1-7A0B886433E0 wds:Q64086091-5CF856F4-CC8C-4F20-A9CD-3E4FCF50CE39 wds:Q64086091-6247B89C-C7B1-4AF1-8482-CD0875B0C5AE wds:Q64086091-656EF914-5275-49B9-8555-56E41F29277F wds:Q64086091-66916961-ECA4-4418-9EE4-C5C8F4CF36E5 wds:Q64086091-6AB93059-6714-4654-BCCC-1D23AFA5C169 wds:Q64086091-71CBAA0F-59DD-4374-AB94-C15584BF165B wds:Q64086091-78DEDAD4-E3D3-4C88-8CE0-96188F7A7128 wds:Q64086091-7D9EEC89-71B2-4C54-A08F-34DCC86C4A15 wds:Q64086091-7DA35846-1B9C-4A74-8B74-AF8068EABD12 wds:Q64086091-834B90A7-AF01-4EA4-BA32-7D59EF066A1D wds:Q64086091-8FB3B473-3443-415F-9BF2-03DF10C7F3AA wds:Q64086091-9B13F9B3-AA7F-4183-9DBE-D401A7BD532A wds:Q64086091-9BB6EB21-186C-4221-95E1-F7BD5E40CAE3 wds:Q64086091-9E03617B-1BD2-49BB-B246-560B18911E41 wds:Q64086091-A071F977-E230-4BB9-9665-B1BD07377ED8 wds:Q64086091-A42294CA-1B5E-41B3-9330-98B1DB26C172 wds:Q64086091-AAD23644-0FCC-4DC7-9C45-ED0A6A3D07A5 wds:Q64086091-ACB22290-CCDA-4E0C-B98B-99D4BEDD91EB wds:Q64086091-B297831D-9A59-4C47-9382-8481822744F7 wds:Q64086091-B8991F0F-0B34-4B6A-8983-2E8BB6F5F409 wds:Q64086091-B8CB78D5-7424-4022-9FC9-048CAAF25532 wds:Q64086091-BAEA18C5-9EB2-4507-B894-11477CD53429 wds:Q64086091-BDABB372-E61A-4625-B8D8-B02EC7603426 wds:Q64086091-C4061741-0517-425B-847C-E228ABDBFDBB wds:Q64086091-C7145209-7CD1-456B-88F4-074F6F7C0AB8 wds:Q64086091-CBF79EF5-7DB4-48B0-90F1-24949DD1C98F wds:Q64086091-CCC20E5E-2E90-4BA9-B02A-AFB6C2B8C074 wds:Q64086091-DC90602C-F0F1-465D-8134-6147A21FB0D3 wds:Q64086091-DFF8854F-8A45-41D2-A3A8-24636048DEFC wds:Q64086091-E32DF139-ACAD-48BD-962B-761BDC359AF2 wds:Q64086091-E65DB50A-A774-404F-B805-F21CFF8015CB wds:Q64086091-E9919FDF-E67B-46A6-BF33-7008370505D1 wds:Q64086091-F8317169-1DF0-42F1-A94D-EA81ECF5F167
cites work	A human MAP kinase interactome Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence Signal integration by JNK and p38 MAPK pathways in cancer development Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival Dysregulation of apoptosis in hepatocellular carcinoma cells ERK activation increases nitroprusside induced apoptosis in human melanoma cells irrespective of p53 status: role of superoxide dismutases. Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines. Effect of mouth cleaning with hinokitiol-containing gel on oral malodor: a randomized, open-label pilot study Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment Fungicidal activity of beta-thujaplicin analogues Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance. Hinokitiol Inhibits Melanogenesis via AKT/mTOR Signaling in B16F10 Mouse Melanoma Cells Hinokitiol, a natural tropolone derivative, offers neuroprotection from thromboembolic stroke in vivo Hinokitiol, a natural tropolone derivative, inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-kappaB. Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3 Antibiotic substances from the heart wood of Thuja plicata D. Don; the constitution of beta-thujaplicin The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence Prooxidant action of hinokitiol: hinokitiol-iron dependent generation of reactive oxygen species Antimicrobial activity and metalloprotease inhibition of hinokitiol-related compounds, the constituents of Thujopsis dolabrata S. and Z. hondai MAK Cell Death Signaling Targeting autophagy in cancer Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells Induction of reactive oxygen species: an emerging approach for cancer therapy Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. "Hepatocellular carcinoma: A life-threatening disease". Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer. Downregulation of cancer stem cell properties via mTOR signaling pathway inhibition by rapamycin in nasopharyngeal carcinoma Autophagy induction for the treatment of cancer Emerging evidence of molecular biomarkers in hepatocellular carcinoma. Hinokitiol suppresses cancer stemness and oncogenicity in glioma stem cells by Nrf2 regulation Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells. Treatment of β-thujaplicin counteracts di(2-ethylhexyl)phthalate (DEHP)-exposed vascular smooth muscle activation, inflammation and atherosclerosis progression.
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