About: Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D

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About: Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D Goto Sponge NotDistinct Permalink

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scientific article published on 24 April 2018

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 2018 (uk) scientific article published on 24 April 2018 (en) im Mai 2018 veröffentlichter wissenschaftlicher Artikel (de) article scientifique publié en 2018 (fr) artículu científicu espublizáu n'abril de 2018 (ast)
publication date	wds:Q64045360-7E67EC91-88D5-4114-88C4-F8FB1A456434
publication date	2018-04-24 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q64045360-B4182266-1315-4879-8BA5-1D1DFBD9B9A3
language of work or name	English
cites work	wds:Q64045360-1F8559A4-A3DA-407D-8A7C-7364864EF69C wds:Q64045360-22CBF7EA-C7A0-4AED-AE86-0A4879EF5C09 wds:Q64045360-38847D92-3158-44FB-B4B7-18E9055B2C83 wds:Q64045360-529E6464-A172-4768-92C5-CF492F93078F wds:Q64045360-55B18D2C-FD08-4737-B020-875CABAC3E38 wds:Q64045360-6B931B79-ECB7-4067-9653-CD31478EC203 wds:Q64045360-7134B5BC-394A-451F-B925-91B6B36D8046 wds:Q64045360-7AE560AD-E214-488D-BF3A-6AB7A286300E wds:Q64045360-7B94C74C-907E-412B-B27E-577033D09DF6 wds:Q64045360-7C395236-0B48-4B37-9881-480613CAD2F5 wds:Q64045360-8503DB4C-DCA1-42E3-BAAC-9BF60ED4E417 wds:Q64045360-8912EBF3-51DC-4A34-8AA0-B399E7EDBB4E wds:Q64045360-9FD13F9F-FA34-4A6D-BDED-4391304D1A80 wds:Q64045360-BFBD4098-D4C7-40D9-B127-CD569046201D wds:Q64045360-D2E40EB7-3737-437B-B2AD-D61E426F11DF wds:Q64045360-D98DC4F1-4A2D-4925-A916-62C68C761A44 wds:Q64045360-E169A7F2-5270-4F13-A49F-7BB299F6242B wds:Q64045360-F45F1C73-B876-4932-BF33-5F23CB861B03 wds:Q64045360-FA1A023F-A0AD-417D-B40B-E0108A821FB2
cites work	The spectrum of complement alternative pathway-mediated diseases Structures of C3b in complex with factors B and D give insight into complement convertase formation Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase Complement factor D, a novel serine protease Structure of human factor D. A complement system protein at 2.0 A resolution Comparative Studies on the Inhibition of Trypsin, Plasmin, and Thrombin by Derivatives of Benzylamine and Benzamidine Models of S/pi interactions in protein structures: comparison of the H2S benzene complex with PDB data. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies (4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome Small-molecule factor D inhibitors targeting the alternative complement pathway Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA) The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex. Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors
author name string	wds:Q64045360-37F4BB6F-F3CD-4D1F-BDDE-5C74C2777F32 wds:Q64045360-4DB13E61-1833-430D-B543-AB5C41F526C5 wds:Q64045360-54AF6D35-73E8-4F4F-AF65-865790A29C4E wds:Q64045360-6528AA86-0D61-4433-ABE4-CBD0D325C9A1 wds:Q64045360-79367444-7F88-4E25-98D8-9804488D5FC9 wds:Q64045360-B21EFF37-6F87-449F-A9AF-5DC39B598B0D wds:Q64045360-C80FF164-599F-4EFD-AE3B-567F40E9CFB8 wds:Q64045360-CA822304-4BCF-425B-AE1B-268F32DAC9C3 wds:Q64045360-D61158DE-8FCA-46A0-ADBF-D7594ADCC856
author name string	Paul Erbel Nils Ostermann Frederic Cumin Jürgen Maibaum Aengus Mac Sweeney Taeyoung Yoon Stefan Randl Anna Vulpetti Simon Rüdisser
rdfs:label	Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D (en) Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D (nl)
skos:prefLabel	Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D (en) Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D (nl)
name	Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D (en) Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D (nl)
author	wds:Q64045360-A3460EC7-C8E4-46F3-ADF7-0B1FAE50D19D
author	Edwige Lorthiois
title	wds:Q64045360-CD7227F8-435D-433F-9CC9-5E12B1BF954C
title	Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D (en)
page(s)	wds:Q64045360-E5B6BC00-10B8-4F54-A04D-F95A5050CDB1
page(s)	490-495
instance of	wds:Q64045360-34F58B6D-9986-4A04-874D-97F1BE6046FA
instance of	scholarly article
PubMed ID	wds:Q64045360-E560D6D4-E3F1-4C32-A3F3-38ABFF7C2C58
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29795765
PubMed ID	29795765
published in	wds:Q64045360-29EDD814-1528-4E3E-B01A-A28AC421B938
published in	ACS Medicinal Chemistry Letters
issue	wds:Q64045360-AB35483E-40D4-4AD5-80C8-E3415EAF0D77
volume	wds:Q64045360-07A1EC55-2F8F-4173-AD11-C349D0D8B5AC
issue	5
volume	9
DOI	wds:Q64045360-EA0E4599-BA27-4A4E-944C-AEA1B7E3CF73
DOI	http://dx.doi.org/10.1021/ACSMEDCHEMLETT.8B00104
DOI	10.1021/ACSMEDCHEMLETT.8B00104
PMCID	wds:Q64045360-908A226F-C92B-48C0-96A0-BF125D7607FC
PMCID	5949727
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q64045360

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