About: Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

scientific article published on 12 November 2018

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в листопаді 2018 (uk) article scientifique publié en 2018 (fr) im November 2018 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en payares de 2018 (ast) 2018 թվականի նոյեմբերի 12-ին հրատարակված գիտական հոդված (hy) scientific article published on 12 November 2018 (en)
publication date	wds:Q59810491-8158CA88-5C2C-4A95-BEC4-9599E0D29F6C
publication date	2018-11-12 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q59810491-6BDF42F8-0512-4753-A4A6-5DDE0D412E00
language of work or name	English
cites work	wds:Q59810491-0D1A15D2-A1E1-438A-96F4-28EB94D4FD6B wds:Q59810491-0F87851D-EDED-46E3-A45A-11C671737CDB wds:Q59810491-126641FF-AB35-4EE8-A85D-0A4EEB3E1921 wds:Q59810491-1286268C-FDD9-481F-B968-D63486F7490B wds:Q59810491-1B9DD9C1-E5BC-4090-8A11-3D24EFA10773 wds:Q59810491-27CD4BB7-7A81-4C66-82B5-18F772C1B0E6 wds:Q59810491-2F6A5671-C591-4020-BAB2-A5CE3E84C424 wds:Q59810491-3F30949B-488D-4F18-BA42-7482908D30E3 wds:Q59810491-45C3E681-249C-4238-ADD5-3C99EA91B1B4 wds:Q59810491-495FBA35-ECB1-4CA1-8790-4D0B295EDBD6 wds:Q59810491-5401567B-4245-4910-B7AD-5C79A190731A wds:Q59810491-58B4F928-920F-4C60-B76E-D383B7424A7F wds:Q59810491-58DD1B04-2F6A-441E-BD54-B80C8C68BF49 wds:Q59810491-5C1870E1-8A63-4780-B170-73F28E4EDFFA wds:Q59810491-5CF8504E-8D5D-4FA7-BE19-6250D5B56BD6 wds:Q59810491-73AA8DD2-FC2F-489E-B7C3-2EB5D254778A wds:Q59810491-7663B8ED-A8E9-4796-AE72-6329F28A6322 wds:Q59810491-7B30AB7E-4391-4925-9374-5EA04E283D80 wds:Q59810491-7DA5A656-42B0-4B14-A0E3-CEDA616563CA wds:Q59810491-7E256C33-DA79-4DA9-94AF-1D3C34DF0F44 wds:Q59810491-819746C3-76E0-4E5E-AE91-A91467F4B2F1 wds:Q59810491-828B6912-A5E4-451B-952D-8F9C860A0AFA wds:Q59810491-892CEF00-6BFC-45A6-A696-A2E224076A91 wds:Q59810491-8E1D2EDF-28A1-4693-8B45-4054885E097D wds:Q59810491-9310F9C1-1023-4202-8E82-54A5F2C58987 wds:Q59810491-9474F095-EF5B-4ABB-A1DC-46F38C229EB8 wds:Q59810491-9521FFE4-8486-44C9-8B11-3C67D31F0B9C wds:Q59810491-997C84D9-FBEC-41D2-A1FC-624E80331B69 wds:Q59810491-A1AA5717-9D50-4F3D-8C24-510DAD88C53E wds:Q59810491-BB8BA06E-BDDE-4FB8-98B1-CAA823C1DB43 wds:Q59810491-BE6A5ECE-E867-4A2E-A5FD-88C47E5EC866 wds:Q59810491-C2332BE5-F4D2-4FD4-97BE-058D02CF9F2F wds:Q59810491-C349FB3E-BB3D-4FB1-9966-A466EE6561CE wds:Q59810491-D5014127-6B0C-445E-9BB0-B02A5D8E93EB wds:Q59810491-D77DB11A-117F-41E3-8C63-6D6B199D5876 wds:Q59810491-DFCC36F5-8553-4C5E-A023-E1AC34CDFA58 wds:Q59810491-E6F28970-F55D-41E7-B020-98E3101D70A5 wds:Q59810491-EFFF7FD3-EF7F-4DCD-8633-11B26AFD743C wds:Q59810491-F7AB4ACB-7430-4AF0-8EA3-4F78AB9DBEED wds:Q59810491-FC27E8A6-76A5-49AC-AD03-940BF42D4891 wds:Q59810491-FC7DA67E-95A4-43B5-9762-B4BF0C52E939
cites work	Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase. VMD: visual molecular dynamics Evaluation of docking performance: comparative data on docking algorithms SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling A new and rapid colorimetric determination of acetylcholinesterase activity RM1: a reparameterization of AM1 for H, C, N, O, P, S, F, Cl, Br, and I Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents Management of acute organophosphorus pesticide poisoning ACPYPE - AnteChamber PYthon Parser interfacE Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides. The value of novel oximes for treatment of poisoning by organophosphorus compounds Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. The acute treatment of nerve agent exposure MolDock: a new technique for high-accuracy molecular docking Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment Pharmacological effects of oximes: how relevant are they? Cholinergic symptoms due to nerve agent attack: a strategy for management A Recent Perspective on Discovery and Development of Diverse Therapeutic Agents Inspired from Isatin Alkaloids Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators Potential of two new oximes in reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by organophosphate compounds: an in vitro study Miniaturization and validation of the Ellman's reaction based acetylcholinesterase inhibitory assay into 384-well plate format and screening of a chemical library First principles calculations of thermodynamics and kinetic parameters and molecular dynamics simulations of acetylcholinesterase reactivators: can mouse data provide new insights into humans? Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method. Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases. Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase. Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors. Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon Peripheral site ligand-oxime conjugates: A novel concept towards reactivation of nerve agent-inhibited human acetylcholinesterase Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin An in vitro comparative study on the reactivation of nerve agent-inhibited guinea pig and human acetylcholinesterases by oximes Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning. Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents Docking and molecular dynamics studies of peripheral site ligand-oximes as reactivators of sarin-inhibited human acetylcholinesterase. Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates
author name string	wds:Q59810491-09461806-4154-4D51-80FD-842D7D0C8436 wds:Q59810491-8B093293-0659-421C-92B8-7F3C88F9205D wds:Q59810491-C0AB95D2-22CE-4C96-B54C-01F317FCD365
author name string	Eugenie Nepovimova Martin Valis Alessandro B C Simas

Faceted Search & Find service v1.16.117 as of May 05 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of May 5 2024, on Linux (x86_64-centos_6-linux-gnu), Single-Server Edition (378 GB total memory, 172 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software