About: Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice

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scientific article published in Nature

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rdf:type	Item
description	artículu científicu (ast) wetenschappelijk artikel (nl) article publié dans la revue scientifique Nature (fr) scientific article published in Nature (en) im März 1989 veröffentlichter wissenschaftlicher Artikel (de) наукова стаття, опублікована в Nature в березні 1989 (uk)
publication date	wds:Q58994134-DB7F1B27-0B05-49B6-82EF-E6656E19180C
publication date	1989-03-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q58994134-496E78B4-187A-4DB8-B870-252AE5EB8AA1
language of work or name	English
exact match	wds:Q58994134-611719FC-CF8F-47A6-9AD2-D633D23ED0EA
exact match	https://scigraph.springernature.com/pub.10.1038/338350a0
cites work	wds:Q58994134-004730E2-F1C5-4A21-B7AA-4EFAC0681E4B wds:Q58994134-046980DE-3D79-4C9D-9309-96C7AF7BC8B0 wds:Q58994134-111C711C-C67D-4F3A-B922-18E1D4BC45B8 wds:Q58994134-1D59289F-28A0-4408-A2F7-1CF1BC2E7786 wds:Q58994134-32715EE4-2178-41EB-94C1-3321D4F7B9DE wds:Q58994134-4123CB11-05DD-4116-AA37-4A33F8EBDBBD wds:Q58994134-53C47DD9-9A2D-4066-B535-F92B9559AC99 wds:Q58994134-609224D5-854F-40F5-9845-098B4BA66678 wds:Q58994134-88BE88B8-1DF2-449D-ABD8-8821AB492D01 wds:Q58994134-A0884E1C-1A30-4942-8677-BEF8319AF5C6 wds:Q58994134-B3D4C0E5-B37E-42A3-884B-A8F119B122F5 wds:Q58994134-BB9FEDB6-757F-4B19-86CB-858266F5AB68 wds:Q58994134-C33BC6FE-0FC2-44ED-B00C-362D5E451ED5 wds:Q58994134-C789C6A6-FD74-437B-86E2-A26DBF444771 wds:Q58994134-D11C3689-1CE4-4867-AB9B-E806F533DB1A wds:Q58994134-D5BB58E1-A69C-4385-AD8E-B2FD0E020478 wds:Q58994134-D83448CF-749B-4BFC-9B16-926FB547DE7C wds:Q58994134-E2D13D67-C115-4A49-9799-034FD5FBFBCC wds:Q58994134-E83C91C3-AC19-478C-A6DC-196A80EFAD61 wds:Q58994134-F52126AA-AEEC-4154-93B5-5A5D25D3275A wds:Q58994134-FCE2D806-FB77-4D3C-8DB1-25FEC083CCCD
cites work	The human CK gene segment and the kappa deleting element are closely linked Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus Sequences of mouse immunoglobulin light chain genes before and after somatic changes Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line Lambda chain expression at different stages of ontogeny in C57BL/6, BALB/c and SJL mice Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice The human kappa deleting element and the mouse recombining segment share DNA sequence homology Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes. POLYPEPTIDE CHAINS OF HUMAN GAMMA-GLOBULIN: CELLULAR LOCALIZATION BY FLUORESCENT ANTIBODY Cmu gene rearrangement of mouse immunoglobulin genes in normal B cells occurs on both the expressed and nonexpressed chromosomes Provision of the immunoglobulin heavy chain enhancer downstream of a test gene is sufficient to confer lymphoid-specific expression in transgenic mice V–J joining of immunoglobulin κ genes only occurs on one homologous chromosome
author name string	wds:Q58994134-5268000F-D813-4CE2-B9F5-FAC908761615 wds:Q58994134-614554B2-0E93-45B0-90D1-C9F4DB6545BF wds:Q58994134-9B934D8E-3CB8-4553-BC13-3FD90653585F wds:Q58994134-CCB145C5-B39D-46BA-B846-EA266BB44396 wds:Q58994134-EB8B406E-2C20-4197-BFA2-BD41F3C9334C
author name string	Neuberger MS Williams GT Surani MA Pettersson S Caskey HM
rdfs:label	Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice (en) Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice (nl)
skos:prefLabel	Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice (en) Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice (nl)
name	Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice (en) Isotype exclusion and transgene down-regulation in immunoglobulin-λ transgenic mice (nl)
title	wds:Q58994134-42712D3B-40E8-4292-85E8-43D95FC838FA
title	Isotype exclusion and transgene down-regulation in immunoglobulin-lambda transgenic mice (en)
page(s)	wds:Q58994134-93EA6DFD-7A82-4F9C-846A-CBA3CDA3D822
page(s)	350-352
instance of	wds:Q58994134-543CE60A-62EC-46FD-A273-7693639F3BC2
instance of	scholarly article
PubMed ID	wds:Q58994134-5FBEF935-BCFE-452A-9555-78D4AD14F362
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2493585
PubMed ID	2493585
published in	wds:Q58994134-3B290DB8-9A2C-4D41-AC40-1641BE8ECF71
published in	Nature
issue	wds:Q58994134-DB94BB3F-5CCA-4416-95C3-979186F25A2C
volume	wds:Q58994134-C3EBEAE7-F4C0-4FCD-86E7-ADB4DC89AE69
issue	6213
volume	338
DOI	wds:Q58994134-DDB09347-3BDC-43BA-8AAF-D656A507C3F2
DOI	http://dx.doi.org/10.1038/338350A0
DOI	10.1038/338350A0
Dimensions Publication ID	wds:Q58994134-A645D022-8860-448E-BAAD-CEFA7E3C37BC
Dimensions Publication ID	1050759287
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q58994134
is cites work of	Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy. Allelic exclusion of immunoglobulin genes: models and mechanisms Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution Up-regulated recombination-activating gene expression in sIg- variants of a human mature B cell line undergoing secondary Ig lambda rearrangements in cell culture Regulation of immunoglobulin light chain isotype expression. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice Antigen receptors on T and B lymphocytes: parallels in organization and function High-level expression of a human immunoglobulin gamma 1 transgene depends on switch region sequences

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