About: Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma

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About: Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma Goto Sponge NotDistinct Permalink

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scientific article published on 21 September 2018

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована у вересні 2018 (uk) im September 2018 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en setiembre de 2018 (ast) scientific article published on 21 September 2018 (en)
publication date	wds:Q58705635-6A67D5C1-F5D3-4080-A07A-EF917969BB91
publication date	2018-09-21 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q58705635-EB443AA0-2A96-4E42-A8BB-29B9D6E746AB
language of work or name	English
exact match	wds:Q58705635-15D9BCFE-BC54-48C5-B9A4-C3A41B34B7DA
exact match	https://scigraph.springernature.com/pub.10.1038/s41389-018-0084-0
cites work	wds:Q58705635-04A12569-A649-4920-AB8E-6F933945EB27 wds:Q58705635-05616CA9-2AC6-4330-BD7C-6611D1A486E5 wds:Q58705635-0B684C93-949D-4BDF-AA2D-3A54720C915E wds:Q58705635-14F38AE8-BEFA-4D3D-B467-928B9A4512A0 wds:Q58705635-180D7250-6D6C-49B9-81C9-C4C839FD52F1 wds:Q58705635-276D3E1A-ED15-42E9-92AE-CB99A54BB5D4 wds:Q58705635-2A8BEC8B-D111-4C19-BF04-A311CE331D55 wds:Q58705635-2BEEA914-7420-4656-80F9-3E28E1C4254F wds:Q58705635-2F9E62AB-4F66-4B04-B321-7A463CADC0EB wds:Q58705635-3C0922E9-C229-4C94-9AB4-6037AB6566DA wds:Q58705635-42DAA3B7-25A0-4A57-8331-6DFDC32E2BA6 wds:Q58705635-49AFE58F-B408-4F7D-AA8D-957519960F16 wds:Q58705635-4DCD410B-4B83-46B3-8CD6-0DEAE73C0090 wds:Q58705635-503E5924-2CA7-42E8-818F-87FA8469C47F wds:Q58705635-55A45781-7806-4E7F-8C77-E276FFE98941 wds:Q58705635-591862E2-2345-402C-AA98-6FF7C3ECC54F wds:Q58705635-5B53397C-C82B-448F-8C0D-4F24FD72BB71 wds:Q58705635-5D2B10D6-9991-4179-927F-1BD1B17827D7 wds:Q58705635-7614FB34-61F5-40A3-92DF-4D57BAE12528 wds:Q58705635-7DB227B4-972F-400E-A981-1DDF6841EF24 wds:Q58705635-82E58682-8B6A-4A2A-B67C-3B5C5109F963 wds:Q58705635-8D8FE806-D48A-4524-8388-5E57D23F1A06 wds:Q58705635-8EBEBC4B-B133-403B-9598-0C2BBB83B2BD wds:Q58705635-A1D36762-9B0D-4E17-A50E-ED266D047F06 wds:Q58705635-A7565F3A-DCBC-4C47-B36B-607B9EE21A08 wds:Q58705635-AAD07437-F642-4B6A-9A63-DAD0D7CF2E0F wds:Q58705635-B0C0329B-8F51-4F90-BF69-94133B7F2D51 wds:Q58705635-B5B631C4-F094-4C0A-9B57-37465D4BBDC5 wds:Q58705635-BC1F6DF5-8016-42A2-AFA7-8B126722C683 wds:Q58705635-BDD9277D-1108-4FDA-8DCF-90F521944DD4 wds:Q58705635-C8D85997-3C78-4B9E-9380-9F231F379070 wds:Q58705635-E13E851D-0B05-49EA-AAA5-BB500776750F wds:Q58705635-E2FE3121-269E-4BC3-914D-4F8ED64C830A wds:Q58705635-FC8B5702-16B4-4DA7-BD9D-7E15BB187C42
cites work	The clinical approach towards chondrosarcoma An inhibitor of Bcl-2 family proteins induces regression of solid tumours Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity Marshall Urist Award. Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma. Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment. Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40. The search for synergy: a critical review from a response surface perspective. Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome Structure-guided design of a selective BCL-X(L) inhibitor An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Inhibition of chondrosarcoma growth by mTOR inhibitor in an in vivo syngeneic rat model Zoledronic acid slows down rat primary chondrosarcoma development, recurrent tumor progression after intralesional curretage and increases overall survival. Systematic discovery of multicomponent therapeutics Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy. MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. Establishment and characterization of a continuous human chondrosarcoma cell line, ch-2879: comparative histologic and genetic studies with its tumor of origin. Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas. Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL. IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas Characterization of a new human cell line (CH-3573) derived from a grade II chondrosarcoma with matrix production Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFβ as potential targets. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.
author name string	wds:Q58705635-122A86EE-9C9A-4F51-9919-D9563D6E598D wds:Q58705635-13DE79CB-6245-428F-BAC6-A2BA5343868A wds:Q58705635-2544DA50-686D-4B59-941C-2CA1E003FF5F wds:Q58705635-5B5114EA-EB1F-4272-912E-D45B8136CDB7 wds:Q58705635-62A864AC-33A7-4EDB-A3AE-0B809AF043DD wds:Q58705635-67940EE3-D778-4891-A5A3-0086C81C5543 wds:Q58705635-C2F98ADC-854C-4A52-BE7B-746ADDB99653 wds:Q58705635-CAC4F699-8CC4-4719-A0F0-409705B6E78B
author name string	Aurélie Dutour Jean Yves Blay Yvonne de Jong Jolieke G van Oosterwijk Brendy E van den Akker David Monderer Emeline Brandinelli Morgane Monchanin
rdfs:label	Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma (en) Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma (nl)
skos:prefLabel	Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma (en) Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma (nl)

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