About: Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62

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About: Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62 Goto Sponge NotDistinct Permalink

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scientific article published on 20 October 2008

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2008 (fr) наукова стаття, опублікована в жовтні 2008 (uk) im Oktober 2008 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'ochobre de 2008 (ast) scientific article published on 20 October 2008 (en)
publication date	wds:Q58425721-DABE98BA-574C-496A-935F-6D6FC76456F9
publication date	2008-10-20 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q58425721-910BF374-45CD-4D13-9A09-6FDAB7E22D34
language of work or name	English
exact match	wds:Q58425721-820E6B5F-47DC-4FC5-B414-54A7BD6D3242
exact match	https://scigraph.springernature.com/pub.10.1038/onc.2008.392
cites work	wds:Q58425721-03323363-A1E4-4256-81B3-E296D8BBD6F3 wds:Q58425721-0438C130-0754-47CD-94D0-B0E70439DF49 wds:Q58425721-0DD3FC99-5CC8-42FE-BAC5-CF033473175F wds:Q58425721-112D68D7-5117-40E7-8FA7-1330C5A476E2 wds:Q58425721-11E23F13-0773-400B-BFBD-D9162BC376CA wds:Q58425721-153A09CA-B040-4B84-B111-F52A7CBB484E wds:Q58425721-16FFC7F5-3D5D-455F-9CD2-D66DDB733DB6 wds:Q58425721-217CEF8D-455F-4ECE-9BA7-BB0299E0E16E wds:Q58425721-26C7AE95-729C-4770-AFD5-84494E7F37AD wds:Q58425721-2E68DED7-EBA8-42DC-B605-30C9C5822658 wds:Q58425721-2E922931-F552-4C75-95BA-CD9A62C85FED wds:Q58425721-31078704-91EC-4B9E-9237-0779FE38A623 wds:Q58425721-3338BD6A-4023-4BCC-A429-9D239A853EC9 wds:Q58425721-336102D7-CA71-4826-AB38-D3D9F555BF53 wds:Q58425721-34339294-AA78-41F4-81BD-DAE991F25792 wds:Q58425721-417360DE-8413-4FBB-B840-56684634CD30 wds:Q58425721-49AC8A2F-D1E8-49C5-8A91-82C4F587F825 wds:Q58425721-54746B4C-7475-4C6B-837C-5D7FE3984D97 wds:Q58425721-63786A62-1E11-4B04-AB93-E1ECB0A149D7 wds:Q58425721-6EFE589D-4D0C-4FA9-8841-A17B5A02E682 wds:Q58425721-729EEBB3-3A0A-4D31-9B56-F8DFFB7A2179 wds:Q58425721-75853CB5-AFE8-4958-A9EF-EA2C7A2DE0CB wds:Q58425721-771818DD-AF7E-470B-8BE8-E8FD54B4B4D8 wds:Q58425721-8DC4D880-5A17-48DB-A210-9780C4B7E001 wds:Q58425721-91FD5DA9-1657-49C6-B329-229AC8B160C0 wds:Q58425721-A65D715E-9F39-49AC-B295-07179F353449 wds:Q58425721-AB9A1210-8407-44E7-8D84-103853A36A8B wds:Q58425721-AEAAB11A-8453-4A82-A883-36F8351299F4 wds:Q58425721-AF8EF5E1-FDC6-430D-B0A2-FBA4D59376EB wds:Q58425721-BACA717A-7717-48A0-8963-128EDC48442C wds:Q58425721-BBC9C27A-AF1B-4941-A684-9F2FA86E1AE9 wds:Q58425721-BC4FB5C3-9313-4441-9CF9-96342BE6F25D wds:Q58425721-C41159DD-76CD-4FA9-A867-3E9030059B74 wds:Q58425721-C6F1F8DF-2EE4-43A4-80BF-AE7617836A28 wds:Q58425721-C88B16C4-9B27-4BC0-AB54-09B2284FF7AE wds:Q58425721-CF9CCB1B-7929-4508-ABE9-6C3F52424651 wds:Q58425721-D5849B7F-C8B7-429E-A159-E4DAE582D238 wds:Q58425721-DC3F9276-3513-47B7-9D88-8EF28AF1ED65 wds:Q58425721-E3949A19-6337-453A-B48E-901ABA729150 wds:Q58425721-E73DC5D3-0321-4303-9A46-60A6C6584301 wds:Q58425721-EAC4CE08-9BDE-46BE-B9F4-E1C8E3431A09 wds:Q58425721-F168F8A0-0140-4579-B18E-4BFB7C9C28D0 wds:Q58425721-F7EB4418-510A-4338-A87D-BB0A95C04C0D wds:Q58425721-F90D1D6D-1774-49AD-B3FC-C49D95970F86 wds:Q58425721-F96B9F88-C637-4A3A-B8E9-053B83D62040
cites work	LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death A conserved family of prolyl-4-hydroxylases that modify HIF HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. The role of autophagy in cancer development and response to therapy. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation ERK activation upon hypoxia: involvement in HIF-1 activation Hypoxia-induced energy stress regulates mRNA translation and cell growth BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells Proline hydroxylation and gene expression Targeting HIF-1 for cancer therapy Autophagy in the Pathogenesis of Disease Autophagy fights disease through cellular self-digestion The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Oxygen sensing by HIF hydroxylases Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes "Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation Regulation of angiogenesis by hypoxia: role of the HIF system Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease. Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.

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