About: Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones

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About: Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones Goto Sponge NotDistinct Permalink

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scientific article published on 28 November 2006

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в грудні 2006 (uk) im November 2006 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 28 November 2006 (en) artículu científicu espublizáu en payares de 2006 (ast)
publication date	wds:Q57976892-810C3ECC-45D7-4934-8844-E2F887A62673
publication date	2006-11-28 00:00:00Z (xsd:dateTime)
author name string	wds:Q57976892-5810594F-1817-4232-BBB6-35E54E855740 wds:Q57976892-989A5C72-8011-4043-95E7-0C8EF7CC4E95 wds:Q57976892-9DFEC003-9930-4F3E-9DC6-E560A501434E
author name string	Ying Wang David M Clarke M Claire Bartlett
rdfs:label	Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones (en) Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones (nl)
skos:prefLabel	Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones (en) Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones (nl)
name	Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones (en) Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones (nl)
author	wds:Q57976892-8E8E2DB9-E4AA-4998-B2D6-3769D899A4C4
author	Tip W. Loo
title	wds:Q57976892-B3F7D9D3-B57F-48B7-AD1D-3B73C7CB53AC
title	Modulating the folding of P-glycoprotein and cystic fibrosis transmembrane conductance regulator truncation mutants with pharmacological chaperones (en)
page(s)	wds:Q57976892-65193F7C-2342-4055-B527-70DBD5AA18A0
page(s)	751-758
instance of	wds:Q57976892-ADA17CB5-BAFF-4F3D-8579-06F74263865A
instance of	scholarly article
main subject	wds:Q57976892-2C0E4099-CB7A-4641-855B-F22D572D2350 wds:Q57976892-49A1774D-CF8D-48C7-8A44-410CB0845FF0 wds:Q57976892-CAEFA9AA-0022-41F4-A588-2A1A4A671E33 wds:Q57976892-E3548E7D-FB32-4254-98F3-0AF0EB5F2C12
main subject	molecular chaperones cystic fibrosis transmembrane protein pharmacology
PubMed ID	wds:Q57976892-AA405DE1-885B-4726-AC00-B42102E232B2
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17132688
PubMed ID	17132688
published in	wds:Q57976892-FF37C9E2-D09C-4E96-A916-43D594730096
published in	Molecular Pharmacology
issue	wds:Q57976892-E8A316A9-CF4A-493D-A17B-342E51478AD5
volume	wds:Q57976892-90B71E71-1FBE-4726-8C42-86A0554424EA
issue	3
volume	71
DOI	wds:Q57976892-06039A0B-63A4-4E07-AEEA-005C3691BCC5
DOI	http://dx.doi.org/10.1124/MOL.106.029926
DOI	10.1124/MOL.106.029926
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q57976892
is cites work of	Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesis Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11. Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites. Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter Functional stability of rescued delta F508 cystic fibrosis transmembrane conductance regulator in airway epithelial cells. Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants The V510D suppressor mutation stabilizes DeltaF508-CFTR at the cell surface. Cooperative assembly and misfolding of CFTR domains in vivo. Chemical and pharmacological chaperones as new therapeutic agents Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators Is CFTR-delF508 really absent from the apical membrane of the airway epithelium? The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease. Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70. Functional roles of glycogene and N-glycan in multidrug resistance of human breast cancer cells Simple image-based no-wash method for quantitative detection of surface expressed CFTR. Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface. P-glycoprotein is fully active after multiple tryptophan substitutions Nano-based rescue of dysfunctional autophagy in chronic obstructive lung diseases The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein. Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept Pharmacological Chaperones: Beyond Conformational Disorders. Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR. CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1) Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein Cargos and genes: insights into vesicular transport from inherited human disease Functional Rescue of F508del-CFTR Using Small Molecule Correctors Repairing the basic defect in cystic fibrosis - one approach is not enough. Modulation of multidrug resistance proteins by statins in human neuroblastoma
is cites work of	wds:Q33728190-B73535F3-FFEF-42FD-9FE1-979782EDE8FB wds:Q39966104-5D109F1F-096B-4BC7-A859-AA43DD7F729B wds:Q64244254-65330915-C754-49B2-83CD-FE265C9399E8 wds:Q27003966-55C012D6-DBAE-4DC8-9909-FA8329D7C6E4 wds:Q34975364-5E751052-B922-47F5-BDD1-7719ACCFB872 wds:Q34179757-E919B941-92BD-4562-83BA-03E41D0DA291 wds:Q33986166-A7F047AF-D980-4B19-B71F-2BD60B2A1D6C wds:Q39897495-5FCE2871-D879-44C6-BD75-1407CC754F61 wds:Q35770985-C29F79D9-8386-49D7-AD98-572E4E5C3E8C wds:Q41790893-E3F0FA0A-3594-40BB-9BA1-68DA75609EC4 wds:Q35325226-3F6C3D38-C625-4DDA-AC81-30CB3CB7AB09 wds:Q38873295-2786F8E4-15C6-4122-8ADD-03B7F4664E68

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