About: Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

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About: Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation Goto Sponge NotDistinct Permalink

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scientific article published on 16 June 2011

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в червні 2011 (uk) im Juni 2011 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 16 June 2011 (en) artículu científicu espublizáu en xunu de 2011 (ast)
publication date	wds:Q57838180-8BA36A92-F6B1-413F-BCAD-A19D845B0B64
publication date	2011-06-16 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57838180-320D0CDD-73E2-405C-B4F5-762F8CBB7C45
language of work or name	English
cites work	wds:Q57838180-0AAAB7D7-5FBD-41A1-AC64-B26B6C13F33D wds:Q57838180-12507B8C-E1B9-481A-BA8D-F8329F6ADC47 wds:Q57838180-2086B4A4-7920-4C33-908D-CD925F12DECE wds:Q57838180-2FE3E3ED-F26B-4CC8-AA50-9EA1CDE6A687 wds:Q57838180-32DA68D6-8690-438C-9798-1D3B42E3D7EA wds:Q57838180-337F370B-D657-42A4-B4A3-194B125F101F wds:Q57838180-35182784-F39D-4D83-A939-CD6845D8D50E wds:Q57838180-3C9F06F3-4E1A-4E87-A27A-D2E7FBFE9E0C wds:Q57838180-5E7E23A1-7277-4F98-A6D8-3CE795DF0015 wds:Q57838180-67A20268-4B95-49E8-80CE-22B08038AEDC wds:Q57838180-68F31477-799C-422A-A794-991861BCFF20 wds:Q57838180-73C1992D-0FC6-445A-A30A-269178BA46B3 wds:Q57838180-836FF0C8-D03A-497A-9880-9B4813455E76 wds:Q57838180-84F6CAE4-631D-4DF6-A597-2C713720E654 wds:Q57838180-89AB2FBA-FDE4-4875-A1EC-9EFF21B728AC wds:Q57838180-92E6854C-3791-4B63-A203-4726653E3DF5 wds:Q57838180-99483E8C-B842-4FE1-9886-9478CA38D543 wds:Q57838180-C065378B-6278-4DDA-B869-4EDD972850CD wds:Q57838180-CBB23A97-7751-49B4-9D22-CC501765DC0D wds:Q57838180-DBD129D7-5B36-449F-B04D-2DD28159D2EC wds:Q57838180-E0C4943B-DC89-445F-A317-93006D310BF2 wds:Q57838180-EC725394-99BC-454D-AB27-E6ECD2263966 wds:Q57838180-ED7C75CE-57FA-4AC3-B7C4-0698BCE9A349 wds:Q57838180-EFC5A7DB-4985-4596-9196-EA491B47EECA wds:Q57838180-F1D0FB9C-4C0F-47D1-B828-0BAC2063A607 wds:Q57838180-F53B8B9A-3CE9-4065-B3B1-DFEFE45F9201
cites work	A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations Glutathione transferases Generalized Gradient Approximation Made Simple PROCHECK: a program to check the stereochemical quality of protein structures The resurgence of platinum-based cancer chemotherapy Direct cellular responses to platinum-induced DNA damage Escaping free-energy minima Efficient exploration of reactive potential energy surfaces using Car-Parrinello molecular dynamics. Biochemical modulation of Cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance The CCP4 suite: programs for protein crystallography Testicular germ-cell cancer. Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance. Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily Glutathione transferases and cancer The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes An Efficient Real Space Multigrid QM/MM Electrostatic Coupling. The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes Structure and function of glutathione S-transferases. Exploring complex protein-ligand recognition mechanisms with coarse metadynamics The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution Flexible docking in solution using metadynamics Glutathione S-transferase polymorphisms: cancer incidence and therapy Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate. Reversal of multiple drug resistance in cholangiocarcinoma by the glutathione S-transferase-pi-specific inhibitor O1-hexadecyl-gamma-glutamyl-S-benzylcysteinyl-D-phenylglycine ethylester.
author name string	wds:Q57838180-11EE4396-4954-443E-BBDF-6CE7BBE4EB88 wds:Q57838180-1AE3E717-380B-474E-BDE5-58015B0C58CA wds:Q57838180-6FCF07A4-F7EE-4721-9EA0-7684E4609D28
author name string	Jade B Aitken Nancy C Hancock Louis C Italiano
rdfs:label	Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation (en) Studies of Glutathione Transferase P1-1 Bound to a Platinum (nl)
skos:prefLabel	Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation (en) Studies of Glutathione Transferase P1-1 Bound to a Platinum (nl)
name	Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation (en) Studies of Glutathione Transferase P1-1 Bound to a Platinum (nl)
author	wds:Q57838180-2F945CCB-A87D-4717-87B1-195059D342FA wds:Q57838180-4C894D75-B4AE-488E-BAF0-3529E67258F4 wds:Q57838180-63479B9F-A6B3-4094-A4B7-9A1F39672BE6 wds:Q57838180-6666CAAD-F7C1-44C0-BF0A-F6C9C0C0EB8B wds:Q57838180-811DB5B2-A9D6-4FF8-9B3B-18E45DDF46DB wds:Q57838180-9ED2C2E0-79F3-4E0D-A9F4-4D105835588E wds:Q57838180-AA758035-6B87-47E6-9826-B94BAC9B4654 wds:Q57838180-B900F1CB-D6EC-43C9-A836-EFDC2BBA2427 wds:Q57838180-D06AD3E3-8113-4E61-9044-F0D436075148 wds:Q57838180-D1AC99A3-DC3E-47EE-91E6-0CD949D7BD22 wds:Q57838180-DBC229F2-AC3A-45FF-8EAD-7F7486C19065
author	Ursula Röthlisberger Pablo Peláez-Campomanes Paul Dyson Michael W Parker Craig J Morton David B Ascher Anastasia De Luca Hugh H. Harris Wee Han Ang Lorien J Parker Jose Mario Bello Pineda
title	wds:Q57838180-0A3B8CB7-45A9-40B2-A8EF-E1FDB0C8F111
title	Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation (en)
page(s)	wds:Q57838180-0FD8BD97-2EAB-494A-94CB-3DA830766118
page(s)	7806-7816

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