About: Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study

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About: Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study Goto Sponge NotDistinct Permalink

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scientific article published on 08 November 2018

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) im Oktober 2018 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en payares de 2018 (ast) наукова стаття, опублікована в жовтні 2018 (uk) scientific article published on 08 November 2018 (en)
publication date	wds:Q57288229-40378F98-6E47-4B4A-AC73-2490E2AC3E59
publication date	2018-11-08 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57288229-1B2E7695-66BA-4C2E-BAD9-34004D4A4B6F
language of work or name	English
cites work	wds:Q57288229-007F19E5-05FE-4CE8-8B67-D9631CDFD491 wds:Q57288229-0375B4F9-B8BF-4E87-8A70-9CA42136C407 wds:Q57288229-16B3D670-9FF6-4202-9569-8DED0153B934 wds:Q57288229-1956E06E-8551-406B-8EC1-BD79BD37AA4C wds:Q57288229-3ED7B0C0-948C-49CE-B899-8E60AF04F4E8 wds:Q57288229-4609C6DE-E1B1-404C-AFFF-59B214681AEC wds:Q57288229-564DB8F5-03FC-4409-A452-5B75867226F9 wds:Q57288229-68321E17-2891-4C82-AC21-880E1E6D1832 wds:Q57288229-69003A48-50B9-48AC-AF88-746E741B3FF8 wds:Q57288229-7160C215-A627-412D-8F38-F35C7A9FB5EA wds:Q57288229-7EE92C8A-DFA6-454E-B7CD-78FCE971E223 wds:Q57288229-9415B701-BA49-417E-B1A1-AC17DF4F530C wds:Q57288229-9C0627FC-C90A-4B92-AECC-6F3B6E6CA561 wds:Q57288229-A525CA8C-C838-43FD-9290-3DEACEAAB50E wds:Q57288229-A5C43757-08AE-4AC7-8C2D-08835759E903 wds:Q57288229-AE7CF403-3A20-4C3C-ADDF-E847ABE844C2 wds:Q57288229-AED0DB70-1225-4110-851C-5405F6A2076C wds:Q57288229-B0B7CAC2-AE9E-4B57-8F51-226963DEB15B wds:Q57288229-B379A17D-3988-48CD-B8FC-6A94FDED09A2 wds:Q57288229-BF8C3CFA-8A57-4104-A6B2-E3BB648AF9DE wds:Q57288229-C0D5140F-C9B4-4876-B6F2-0BD5B45D754A wds:Q57288229-CCBDBEC2-2743-4F93-B237-E661E34390FB wds:Q57288229-D3D2CC84-D0BC-4D23-B5B7-A9A39CE1C2C6 wds:Q57288229-EDE6C78D-3FE4-4B4B-94D1-4CD52493C459 wds:Q57288229-F2E34574-A7EC-40B3-BD9D-8B12C024D870
cites work	Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults Cloning and functional expression of a human liver organic cation transporter Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children. Epirubicin glucuronidation and UGT2B7 developmental expression. Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort. Morphine pharmacokinetics and pharmacodynamics in preterm and term neonates: secondary results from the NEOPAIN trial Innovative clinical trial design for pediatric therapeutics Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver Prediction of morphine dose in humans. Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography–tandem mass spectrometry Prediction of morphine clearance in the paediatric population : how accurate are the available pharmacokinetic models? Morphine clearance and effects in newborn infants in relation to gestational age. Evidence-based morphine dosing for postoperative neonates and infants. Respiratory effects of intravenous morphine infusions in neonates, infants, and children after cardiac surgery Morphine glucuronidation in preterm neonates, infants and children younger than 3 years Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes. Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children. Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter. OCT1 pharmacogenetics in pain management: is a clinical application within reach? OCT1 genetic variants influence the pharmacokinetics of morphine in children. Use of opportunistic clinical data and a population pharmacokinetic model to support dosing of clindamycin for premature infants to adolescents Pharmacokinetic Studies in Neonates: The Utility of an Opportunistic Sampling Design. PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants
author name string	wds:Q57288229-32A3D2F9-91E9-49AF-A4B1-3069C40D2776 wds:Q57288229-97395471-B536-4C94-A0A9-21FE791935D4 wds:Q57288229-AFECD7DD-BED1-4DA9-B9A0-85CE3CB63D1D wds:Q57288229-DF53B78D-41AB-475E-A96B-2377E1908585 wds:Q57288229-F22AB0AB-98DA-4E99-9CE1-11DFAE0D568D wds:Q57288229-FCFBE411-AB3F-415D-9858-6A431443E317
author name string	David Hahn Alexander A Vinks Tomoyuki Mizuno Tsuyoshi Fukuda Chie Emoto Joshua C Euteneuer
rdfs:label	Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study (en) Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study (nl)
skos:prefLabel	Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study (en) Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study (nl)
name	Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study (en) Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study (nl)
author	wds:Q57288229-0E77B930-70FE-4300-8C61-4D4BBEF61276 wds:Q57288229-102C36A2-1CB0-4D85-B88A-BCB7697F6438 wds:Q57288229-16F34077-44B7-478D-8928-084626A843E9 wds:Q57288229-29367FE8-F56D-40B7-AE8C-0385FDEDE16A wds:Q57288229-5A5BEAA0-FF2A-4118-AED1-C98230348A45 wds:Q57288229-62FD5204-F813-4B70-9CDD-8F5AE2440540
author	Alexander Vinks David R Hahn Chie Emoto Tomoyuki Mizuno Tsuyoshi Fukuda Joshua C Euteneuer
title	wds:Q57288229-92DC1083-28B3-45E2-87DD-A2E9BA027C20
title	Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study (en)
page(s)	wds:Q57288229-9C888FE4-BB63-4B7F-B3CD-40067E9E200E
page(s)	761-768
instance of	wds:Q57288229-59B9B5A7-98F2-490D-A6A1-9F378E74DAFB
instance of	scholarly article
main subject	wds:Q57288229-97EBE7B7-D88F-4A8A-8DF4-DDE23F9ADBFA
main subject	morphine
PubMed ID	wds:Q57288229-0D2DDE5E-37F9-4C4F-8BC6-8D1C4E143B28
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30300922

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