About: The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1

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scientific article published in Journal of Biological Chemistry

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rdf:type	Item
description	artículu científicu (ast) wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 2000 (uk) article publié dans la revue scientifique Journal of Biological Chemistry (fr) im August 2000 veröffentlichter wissenschaftlicher Artikel (de) scientific article published in Journal of Biological Chemistry (en)
publication date	wds:Q57268727-B63A55E5-3C08-4013-A7CD-4C6C1C184E16
publication date	2000-08-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57268727-484A0844-0220-414E-87BF-E7E876B27B51
language of work or name	English
cites work	wds:Q57268727-03009774-D07B-450B-94FC-2A4CE1DDAFFE wds:Q57268727-10A457EA-9BAB-460A-BC24-1A0DDAA67E0A wds:Q57268727-1BB841C6-3EE2-4485-8642-09628A19AE4F wds:Q57268727-41C25AB7-2BD9-46FC-B176-E94ECEFFEDB4 wds:Q57268727-62629882-3D84-4BDF-B3BC-FFE57BA4965D wds:Q57268727-668ED455-63A8-43A5-9B3D-C0A3CAF9E985 wds:Q57268727-66FF0006-799A-4A0A-B30D-F8F061597C8C wds:Q57268727-70CD86C3-941F-46DA-87AF-AA1916776D25 wds:Q57268727-755293EB-6F39-4C5E-BBBA-F29997083CFB wds:Q57268727-75685056-B4D6-4BA1-BBE2-5871E9D483B8 wds:Q57268727-764C8072-66CE-4E20-B3CE-5D05F89BE623 wds:Q57268727-7FB09B30-452B-4E96-909E-1885069AF272 wds:Q57268727-9F54910C-C454-4466-AC66-612F3318CA28 wds:Q57268727-A08A6415-1DCF-4D5E-B11F-89DBC6AFE559 wds:Q57268727-AA76D1FA-51AF-4528-8A04-655A1148FE33 wds:Q57268727-C21FF088-57FE-47DA-A3D2-BEB0584A87B4 wds:Q57268727-D4D9FDA0-A0E9-4C9D-AC2F-D7A180B3DDBF wds:Q57268727-D681C8E2-D566-40A5-823C-C8AFC66AFB97 wds:Q57268727-EA77D134-CDE3-43A5-9722-6EAF061BBCA9 wds:Q57268727-EF91229C-1D84-4500-9AE1-87CF07D69476 wds:Q57268727-F0A0C34F-1DAC-4873-AD99-5FCD2CC6804D wds:Q57268727-F1AB394C-3A1E-4AE2-80D7-90571E2030C1 wds:Q57268727-F2EDF7B5-57CF-4170-A2AE-864D42FC5768 wds:Q57268727-F5CE227B-8D9D-4F92-9BA7-2503FE8C1090 wds:Q57268727-FCE3F77F-3440-476B-8666-73BB02231F62
cites work	Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues Eukaryotic protein processing: endoproteolysis of precursor proteins 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway Pro-protein convertases of subtilisin/kexin family. Identification of the region within the neuroendocrine polypeptide 7B2 responsible for the inhibition of prohormone convertase PC2 The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity In vitro characterization of the novel proprotein convertase PC7. Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60. The pituitary polypeptide "7B2" is associated with LH/FSH and TSH cells and is localized within secretory vesicles. 7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines Localization of metallocarboxypeptidase D in AtT-20 cells. Potential role in prohormone processing. Proteolytic processing in the secretory pathway Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing. Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity Two activation states of the prohormone convertase PC1 in the secretory pathway Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: a potential mechanism for its inactivation Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library
author name string	wds:Q57268727-09F62E7B-7264-48AD-A337-6C70AED0D853 wds:Q57268727-292F17EB-EA06-4040-B4BA-2477DF689C16 wds:Q57268727-3DFE46DB-31B0-4554-8473-5DB39EE0D02E wds:Q57268727-E07997F6-2511-4D4F-B29A-FA4CA29C8345
author name string	L D Fricker Y Qian L A Devi S Munzer
rdfs:label	The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1 (en) The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1 (nl)
skos:prefLabel	The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1 (en) The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1 (nl)
name	The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1 (en) The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1 (nl)
author	wds:Q57268727-4BC86F5C-36AB-4567-97F8-3818D48CD906 wds:Q57268727-582C34BC-1B43-4070-BACE-13D4316A6DFC
author	Nabil Seidah Nino Mzhavia
title	wds:Q57268727-29E8251E-17D9-4C01-94FE-E04A2B34855C
title	The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1 (en)
page(s)	wds:Q57268727-2C9C06C0-20B0-4962-8E71-05A3012C9F41
page(s)	23596-23601
instance of	wds:Q57268727-E06A8A39-E5E0-4B4C-B9A1-00705006982D
instance of	scholarly article
PubMed ID	wds:Q57268727-93BFF8C9-6A9F-45AD-AEB9-A7BDC180F647
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10816562
PubMed ID	10816562
published in	wds:Q57268727-30A8AF30-DE8F-4556-A3A5-E6B67EAF2235
published in	Journal of Biological Chemistry
issue	wds:Q57268727-14F20D95-DC76-46A1-8A04-0982C809E6D0
volume	wds:Q57268727-E54744FD-BE64-478D-B97A-C141705A0FCB
issue	31
volume	275
DOI	wds:Q57268727-47D324F1-5E96-41E2-BEAB-4907FEB586B0
DOI	http://dx.doi.org/10.1074/JBC.M001583200
DOI	10.1074/JBC.M001583200
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q57268727
is cites work of	MALDI imaging mass spectrometry to investigate endogenous peptides in an animal model of Usher's disease Potential opportunity in the development of new therapeutic agents based on endogenous and exogenous inhibitors of the proprotein convertases

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