About: Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding

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scientific article published on 01 October 2002

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в жовтні 2002 (uk) مقالة علمية تنشرت ف 1 أكتوبر 2002 (ary) article scientifique publié en 2002 (fr) im Oktober 2002 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'ochobre de 2002 (ast) scientific article published on 01 October 2002 (en)
publication date	wds:Q57257284-1CE2A39F-7DED-40A2-A790-4243B81DD71F
publication date	2002-10-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57257284-B32DA271-9431-4F0E-B476-AFDF32BC30F8
language of work or name	English
author name string	wds:Q57257284-0D588813-93A9-417E-B5DB-4DC6DD551DFA
author name string	Helmut R Salih
rdfs:label	Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (en) Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (nl)
skos:prefLabel	Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (en) Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (nl)
name	Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (en) Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (nl)
author	wds:Q57257284-065A5113-2802-4041-9FD9-8B2C2CC97658 wds:Q57257284-42ADEE2F-1FB5-44C4-9710-F561248CEADF
author	Hans-Georg Rammensee Alexander Steinle
title	wds:Q57257284-F8926820-7415-4815-B41D-29B76DBE671F
title	Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding (en)
page(s)	wds:Q57257284-1E8A11FF-C781-41D0-93BE-78EFD93DA550
page(s)	4098-4102
instance of	wds:Q57257284-A17011E8-5851-4570-9585-5F5A71A1BB6B
instance of	scholarly article
main subject	wds:Q57257284-09D346B1-E3A8-4D7E-B4DD-E8759F712077
main subject	proteolysis
PubMed ID	wds:Q57257284-EADCF61E-8E29-481A-A30A-EF869536A1BF
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12370336
PubMed ID	12370336
published in	wds:Q57257284-DDC84F37-2759-41AA-B649-BC998FD079EC
published in	Journal of Immunology
issue	wds:Q57257284-2E50FEF9-0703-47FA-94EF-E539BF470401
volume	wds:Q57257284-C63ED03D-D568-4D44-BC7B-56955F0F1F2E
issue	8
volume	169
DOI	wds:Q57257284-72DAB8C6-8529-44E2-A308-4FDD350D9ABC
DOI	http://dx.doi.org/10.4049/JIMMUNOL.169.8.4098
DOI	10.4049/JIMMUNOL.169.8.4098
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q57257284
is cites work of	Human NKG2D-ligands: cell biology strategies to ensure immune recognition Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis Human MHC class I chain related (MIC) genes: their biological function and relevance to disease and transplantation NKG2D and Related Immunoreceptors Regulation of ligands for the activating receptor NKG2D. NKG2D ligands in tumor immunity Effect of NKG2D ligand expression on host immune responses Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis. Opposing effects of interferon-alpha and interferon-gamma on the expression of major histocompatibility complex class I chain-related A in tumors. Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity. The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabine-induced MICA/B expression MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17. Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma Molecular Bases for the Regulation of NKG2D Ligands in Cancer. Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells. The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Opportunities and limitations of natural killer cells as adoptive therapy for malignant disease Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation Immune functions encoded by the natural killer gene complex Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions Generation of soluble NKG2D ligands: proteolytic cleavage, exosome secretion and functional implications Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9. Thermodynamic analysis of degenerate recognition by the NKG2D immunoreceptor: not induced fit but rigid adaptation NK cell-based immunotherapy for malignant diseases Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1 Cancer-Induced Alterations of NK-Mediated Target Recognition: Current and Investigational Pharmacological Strategies Aiming at Restoring NK-Mediated Anti-Tumor Activity RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer. Hepatitis B virus-induced hepatocellular carcinoma: functional roles of MICA variants. Characterization of alternatively spliced transcript variants of CLEC2D gene Crystal Structure of the Cowpox Virus-Encoded NKG2D Ligand OMCP Expression of the RAE-1 family of stimulatory NK-cell ligands requires activation of the PI3K pathway during viral infection and transformation Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis. Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma Tumor stroma-associated antigens for anti-cancer immunotherapy Tumor escape mechanisms: potential role of soluble HLA antigens and NK cells activating ligands NKG2D ligands: unconventional MHC class I‐like molecules exploited by viruses and cancer Regulation of ligands for the NKG2D activating receptor

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