About: Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice

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About: Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice Goto Sponge NotDistinct Permalink

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article by Nadja Herbach et al published 15 February 2007 in Diabetes

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в лютому 2007 (uk) im Februar 2007 veröffentlichter wissenschaftlicher Artikel (de) article by Nadja Herbach et al published 15 February 2007 in Diabetes (en)
publication date	wds:Q57198017-1694F9C4-E831-48CB-AE1D-2E30523A30B7
publication date	2007-02-15 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57198017-AF8580FE-C538-445A-A252-E025FBAA304F
language of work or name	English
author name string	wds:Q57198017-1C50051C-E74D-40AC-B18A-EF445328AF65 wds:Q57198017-5B50F7B4-76C6-4550-B1B7-5F8D9A09C7AE wds:Q57198017-694D4E0E-BF33-405F-A56A-B1B4A40BD1A4 wds:Q57198017-7B32FB1B-FA44-4762-94DC-0529C1C1721A wds:Q57198017-B8FB623F-6BF5-4122-AA44-08053F3D4F29
author name string	P. A. Halban M. H. de Angelis B. Rathkolb L. Pichl M. Klaften
rdfs:label	Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice (en) Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice (nl)
skos:prefLabel	Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice (en) Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice (nl)
name	Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice (en) Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice (nl)
author	wds:Q57198017-236D4B67-1764-49E9-85DB-9B19E69BFDA3 wds:Q57198017-2FCBF56F-D5A6-4CAE-8415-D67CF01AC20B wds:Q57198017-6A7B6E93-DF38-455D-89B8-3ED141ECC48D wds:Q57198017-7662FF1B-8BD2-4D03-A6DC-274F0E7E0AF9 wds:Q57198017-AE13A729-C365-4708-869F-D4FC5792D305
author	Eckhard Wolf Rüdiger Wanke Nadja Herbach Bernhard Aigner Elisabeth Kemter
title	wds:Q57198017-463A01D6-1D17-401F-894D-6C93C81A655E
title	Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice (en)
page(s)	wds:Q57198017-165F4688-47AA-4133-A61A-E08567531E1A
page(s)	1268-1276
instance of	wds:Q57198017-6685A84C-BE32-4881-AFAC-D61111BA5820
instance of	scholarly article
PubMed ID	wds:Q57198017-D2901035-6DFD-4B29-AAA5-8370F8C71CDD
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17303807
PubMed ID	17303807
published in	wds:Q57198017-CA1C842D-1F6A-4D09-8810-B5F04F202422
published in	Diabetes
issue	wds:Q57198017-9CA65FDA-B3E3-4A3A-B497-3A277AF28527
volume	wds:Q57198017-4EA7D805-8A04-4E39-BA8D-435A7C150BB8
issue	5
volume	56
DOI	wds:Q57198017-16283DB8-7F4F-4C2B-81F5-903A6B89B477
DOI	http://dx.doi.org/10.2337/DB06-0658
DOI	10.2337/DB06-0658
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q57198017
is cites work of	Diabetes mellitus due to the toxic misfolding of proinsulin variants [Pathogenesis of diabetes mellitus and diabetic complications. Studies on diabetic mouse models]. Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function Targeting endoplasmic reticulum stress in metabolic disease The role of the unfolded protein response in diabetes mellitus Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes The binary switch between life and death of endoplasmic reticulum-stressed beta cells Endoplasmic reticulum stress in beta-cells and development of diabetes Maternal influence of prolyl endopeptidase on fat mass of adult progeny Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene Insulin gene mutations and diabetes Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived β-cells Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress Neonatal diabetes mellitus: a model for personalized medicine Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells Genetic and Pharmacologic Models for Type 1 Diabetes Endoplasmic reticulum stress and pancreatic β-cell death Insulin gene mutations as a cause of permanent neonatal diabetes Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Transgenic pigs as models for translational biomedical research Misfolded proinsulin affects bystander proinsulin in neonatal diabetes Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats. Neonatal diabetes mellitus Proinsulin and the genetics of diabetes mellitus Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity Surrogate measures of insulin resistance: of rats, mice, and men. Proinsulin maturation, misfolding, and proteotoxicity Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease Permanent neonatal diabetes in INS(C94Y) transgenic pigs. Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass Diabetes as a disease of endoplasmic reticulum stress Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? A switch from life to death in endoplasmic reticulum stressed β-cells In vivo misfolding of proinsulin below the threshold of frank diabetes. INS-gene mutations: from genetics and beta cell biology to clinical disease Low alpha-synuclein levels in the blood are associated with insulin resistance Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic glucose clamps in rhesus monkeys The role of autophagy in endoplasmic reticulum stress-induced pancreatic β cell death Genetics and pathophysiology of neonatal diabetes mellitus

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