About: Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

article

Attributes	Values
rdf:type	Item
description	article (en) ലേഖനം (ml) wetenschappelijk artikel (nl) наукова стаття, опублікована у вересні 2014 (uk) article scientifique publié en 2014 (fr) im September 2014 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q56864501-5315121E-72BD-4CDB-AF29-8A2D6C8C298B
publication date	2014-09-07 00:00:00Z (xsd:dateTime)
exact match	wds:Q56864501-A19159FC-68F8-4FAC-BBD1-F608D9AD6A2A
exact match	https://scigraph.springernature.com/pub.10.1038/nbt.2968
cites work	wds:Q56864501-0191395C-9282-45E9-AB3B-00EB0BF044CB wds:Q56864501-1861F39D-7A71-4847-BED0-C24D86C88CFC wds:Q56864501-2429D775-8CA1-4433-81A0-CB09CEA70BC5 wds:Q56864501-29E3C85E-7325-4231-813A-129990432281 wds:Q56864501-2D700FCB-FDC0-485A-8D4C-527152A2DE94 wds:Q56864501-31D332FF-ADC5-468E-9F4C-6179302F0325 wds:Q56864501-325C04D2-D814-4FD4-B7DE-2D83DA51F969 wds:Q56864501-3461BDA7-B89C-43E1-B435-770212AF58B0 wds:Q56864501-35EAE4CD-28B5-4BED-92BE-9D2DD782A3D9 wds:Q56864501-394CC2B2-0BC2-4857-A7CE-D3DAE85C9EB0 wds:Q56864501-3B283998-F6AA-41C9-A50D-F4EAF5161503 wds:Q56864501-3FF6A9FD-17C3-4160-96B5-6AF4F540C5BB wds:Q56864501-4254624B-FB47-41FC-9DB3-01409BDF0D85 wds:Q56864501-4BA371AB-2C84-42BC-B4FF-A2ECC88DACEE wds:Q56864501-4FFA314C-897D-4F94-8C87-EF72074B612B wds:Q56864501-65BF2355-70F0-466A-81FB-54DA44AFC140 wds:Q56864501-75FC9CE1-99EA-4BC9-8793-0CCA0AFCAA55 wds:Q56864501-885F7D3E-58B8-495C-A4E1-F7391F76EEF7 wds:Q56864501-8B7397E2-2A92-43FF-8574-DA39CE4DDF6F wds:Q56864501-9DA722FF-3768-47E0-84FF-B0E31607139A wds:Q56864501-AA5CCB11-8268-40CA-A205-D197981B2B07 wds:Q56864501-AF810638-0696-40BB-A8A6-A7370AEEAB46 wds:Q56864501-B34CCA2F-DA3B-4176-94AE-14B9F5CC9082 wds:Q56864501-B8206648-99FB-42A7-A8FC-B2C636C6DFFC wds:Q56864501-C7CEE873-7F5D-4C85-8F78-36624ABF1547 wds:Q56864501-D5794FDE-7BF5-4109-B60D-C1F6B95ABEAE wds:Q56864501-D5ACB880-818A-4083-BFC0-C23AB344954E wds:Q56864501-DF0FFEF9-3AFC-4765-B766-C94A55B9DE03 wds:Q56864501-EDDF87DF-4181-43CB-B533-AD8AE4B9F71C
cites work	Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer Advancing antibody drug conjugation: from the laboratory to a clinically approved anticancer drug Antibody-drug conjugates: an emerging concept in cancer therapy Development of potent monoclonal antibody auristatin conjugates for cancer therapy Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis Antibody-drug conjugates in cancer therapy Antibody-drug conjugate (ADC) clinical pipeline: a review The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates Maturing antibody-drug conjugate pipeline hits 30. A Pictet-Spengler ligation for protein chemical modification Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Contribution of linker stability to the activities of anticancer immunoconjugates Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology. Trastuzumab emtansine: the first targeted chemotherapy for treatment of breast cancer Catalysis of imido group hydrolysis in a maleimide conjugate cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity Conjugation of anticancer drugs through endogenous monoclonal antibody cysteine residues Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides A general approach to site-specific antibody drug conjugates Antibody-drug conjugates. The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma Tunable degradation of maleimide-thiol adducts in reducing environments A new reagent for stable thiol-specific conjugation Hydrolysis of p-NN′-phenylenebismaleimide and its adducts with cysteine. Implications for cross-linking of proteins
author name string	wds:Q56864501-05BFF052-251E-452E-9A1D-4D3974B680CD wds:Q56864501-0A2EA9BB-E638-4F2C-A709-800B20CEE986 wds:Q56864501-0DC4D891-8538-4211-AC4E-ADFFE6394313 wds:Q56864501-0F0E9F5C-353E-4101-8B9E-E7666DFBCB98 wds:Q56864501-4AF52008-9CEF-4F52-9FDC-F49D54F7ABF8 wds:Q56864501-5CD4E95C-85BF-4037-8DCB-7468919D8BF0 wds:Q56864501-64ABF73E-B945-47F8-8FD7-0EFA12DFFE53 wds:Q56864501-88F01295-246B-498D-A740-DA25383DD244 wds:Q56864501-CBF9346B-1C31-422A-92DB-E145FC3C36DF wds:Q56864501-E1DE7D67-006A-4F35-8FD4-0D3712D84EB6 wds:Q56864501-F516A3E5-80AD-42A0-AEE8-C75060469922
author name string	Robert P Lyon Fu Li Peter D Senter Martha E Anderson Steven M Duniho Svetlana O Doronina Tim D Bovee Joshua H Hunter Chris I Leiske Cindy L Balasubramanian Jocelyn R Setter
rdfs:label	Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates (en) Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates (nl)
skos:prefLabel	Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates (en) Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates (nl)
name	Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates (en) Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates (nl)
title	wds:Q56864501-9B62B37C-DEAC-42BD-86CC-3E5DFCC4F872
title	Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates (en)
page(s)	wds:Q56864501-95159D9B-D51F-44CF-820D-828897A7ADD0

Faceted Search & Find service v1.16.117 as of May 05 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of May 5 2024, on Linux (x86_64-centos_6-linux-gnu), Single-Server Edition (378 GB total memory, 183 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software