About: RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis

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About: RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis Goto Sponge NotDistinct Permalink

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description	article (en) ലേഖനം (ml) wetenschappelijk artikel (nl) наукова стаття, опублікована у вересні 2007 (uk) im September 2007 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q56333589-27A78A70-E9AC-413E-BB40-0A4B415B7494
publication date	2007-09-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q56333589-ADEC63B2-61C8-4911-B7D6-0DB930AEC046
language of work or name	English
exact match	wds:Q56333589-FE2D40F2-545A-4172-BA1D-7B56BCD847BD
exact match	https://scigraph.springernature.com/pub.10.1038/ng2096
cites work	wds:Q56333589-01AC3CF7-FAEA-4DF8-9C99-A2123126F535 wds:Q56333589-01B421EF-86FE-4F99-BC1C-8B50F4745B58 wds:Q56333589-11BBBE20-1487-4ACE-AAD3-1EB7A5856308 wds:Q56333589-1F4281EC-9AD5-4BFE-A465-8EB0E52A24AB wds:Q56333589-277C8598-D780-4802-83A2-F1E1C838A212 wds:Q56333589-2C9E479C-C432-498B-B28A-0CE77E7E59F1 wds:Q56333589-32B0F785-F795-49F6-91D7-B77967AE004E wds:Q56333589-35FC0F6A-3905-4EAB-8CBE-91E3F10E74B3 wds:Q56333589-36AB8048-DCAB-4FFE-BE5F-E9B84C8BEF35 wds:Q56333589-3BA98A86-FD47-4431-85C5-5F83E6B703C9 wds:Q56333589-4A6D5D57-8A85-47B3-8949-2DBB1B7C80CE wds:Q56333589-5059BD79-C907-4E4E-83A5-2D7D7B921CBC wds:Q56333589-52399112-E1F0-42D1-A5FD-5534BC960A63 wds:Q56333589-58DA5995-ADC3-4B84-8824-2FFE9FDB4F9B wds:Q56333589-5E31CF31-DFF3-4E17-9A76-113737609383 wds:Q56333589-691D28F1-2D57-4A66-AC5B-F40A07E3DB45 wds:Q56333589-72B553C2-1D41-4C75-A7E9-86664954E506 wds:Q56333589-7ED4E0EE-FCCD-4676-B3E4-908405E90681 wds:Q56333589-80D2B8A7-D7FD-4CB1-8FC5-AA4ABCD3492D wds:Q56333589-81AE0A8D-E0A0-4692-A43B-26C5E0EF29A8 wds:Q56333589-A09B8976-A715-40E1-88FF-ECE07267E128 wds:Q56333589-B29F68CC-04BA-4489-91A5-F518ACC51197 wds:Q56333589-B73D87E1-1C5C-4B8B-BE24-0FEEA1A4D7E3 wds:Q56333589-C5F5C312-3965-4563-8F71-5048C6DCA066 wds:Q56333589-E825DC7B-46B4-4A8E-9171-0D3A36B93B2D wds:Q56333589-EF96CF66-D87E-4DBC-9702-E8614B52F57C wds:Q56333589-FB7CC81A-8255-470B-8E61-2F12863D8DDB
cites work	Identification of a novel inhibitor of mitogen-activated protein kinase kinase Management of craniosynostoses Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. Fibroblast-growth-factor receptor mutations in human skeletal disorders A DNA vector-based RNAi technology to suppress gene expression in mammalian cells FGF-2 acts through an ERK1/2 intracellular pathway to affect osteoblast differentiation. Roles of FGF receptors in mammalian development and congenital diseases Fibroblast growth factors, their receptors and signaling Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model The ERK cascade: a prototype of MAPK signaling Exclusive paternal origin of new mutations in Apert syndrome Activation of extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) by FGF-2 and PDGF-BB in normal human osteoblastic and bone marrow stromal cells: differences in mobility and in-gel renaturation of ERK1 in human, rat, and mouse osteoblast Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis. A Ser250Trp substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis Efficient in vivo manipulation of mouse genomic sequences at the zygote stage Roles of FGF signaling in skeletal development and human genetic diseases Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system. The pleiotropic effects of fibroblast growth factor receptors in mammalian development. Fibroblast growth factor (FGF)-2 directly stimulates mature osteoclast function through activation of FGF receptor 1 and p42/p44 MAP kinase Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. A model for the pharmacological treatment of crouzon syndrome Sprouty proteins: antagonists of endothelial cell signaling and more Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference Syndromes involving craniosynostosis and midface hypoplasia
author name string	wds:Q56333589-2790EEB0-17C7-4802-9753-1AF3F15EF192 wds:Q56333589-54F5004C-6AAE-463F-9FAD-72DCBCFF1290 wds:Q56333589-7B3115EB-33B1-4AC9-A1F3-8486A68C7DF7 wds:Q56333589-F8FBC3FD-EB4A-4B10-A8DB-20772FBB099B
author name string	Chu-Xia Deng Hyun-Seok Kim Rui-Hong Wang Vivek Shukla
rdfs:label	RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis (en) RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis (nl)
skos:prefLabel	RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis (en) RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis (nl)
name	RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis (en) RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis (nl)
author	wds:Q56333589-09D24EF1-1DC5-4D17-B433-6DD3B22FB130
author	Xavier Coumoul
title	wds:Q56333589-E45FEE97-C77D-47B2-9B2B-24EED3F8D5BC
title	RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis (en)
page(s)	wds:Q56333589-C4D46CA7-D566-4A7B-B239-E851916EC653
page(s)	1145-50
instance of	wds:Q56333589-D8F179E7-16AD-4C76-95C2-51AC810E1E71
instance of	scholarly article
main subject	wds:Q56333589-70A61580-D0F9-4B5A-8135-B72507E8EDBB wds:Q56333589-D6B40724-44BD-47B9-847A-DA0CAA41A6E7 wds:Q56333589-DFDA3AB4-2539-41BA-B778-FE1EF3683817
main subject	phenotype RNA interference craniosynostosis
PubMed ID	wds:Q56333589-7A17160E-3E4D-423A-AE79-D86B5DDE5451
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17694057
PubMed ID	17694057
published in	wds:Q56333589-32141BE8-739A-4C42-93CE-61A6E3DDD3E7
published in	Nature Genetics
issue	wds:Q56333589-3071FEAE-40C4-4EB6-B197-E6CA649A627F

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