About: Apical ectodermal ridge

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An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

Critical component of vertebrate limb development. It controls limb distal outgrowth.

Attributes	Values
rdf:type	Item
description	Critical component of vertebrate limb development. It controls limb distal outgrowth. (en)
rdfs:label	Apical ectodermal ridge (en) Cresta ectodérmica apical (ca) Cresta ectodérmica apical (es) Crista ectodermal apical (pt) Crista ectodérmica apical (pt-br) خط‌الرأس اکتودرمال آپیکال (fa)
skos:prefLabel	Apical ectodermal ridge (en) Cresta ectodérmica apical (ca) Cresta ectodérmica apical (es) Crista ectodermal apical (pt) Crista ectodérmica apical (pt-br) خط‌الرأس اکتودرمال آپیکال (fa)
name	Apical ectodermal ridge (en) Cresta ectodérmica apical (ca) Cresta ectodérmica apical (es) Crista ectodermal apical (pt) Crista ectodérmica apical (pt-br) خط‌الرأس اکتودرمال آپیکال (fa)
Freebase ID	wds:Q4779801-D7CA1B91-C1E0-48E3-9C37-B026B6ABA3CF
Freebase ID	/m/0fycsg
image	wds:Q4779801-ea583a88-4f34-2c31-20cc-384ab3505478
image
subclass of	wds:Q4779801-1919e3f3-42ac-098d-e0b0-6d7704ba51ad wds:Q4779801-321e2c9a-4159-1d2e-1a9a-66ecebcb932a
subclass of	embryonic structure group of cells
UBERON ID	wds:Q4779801-2664C870-E5AD-439D-A416-0A7C4B4F551E
UBERON ID	http://purl.obolibrary.org/obo/UBERON_0004356
UBERON ID	0004356
anatomical location	wds:Q4779801-c71847a0-4bb9-171f-480b-6c124b7ce177
anatomical location	limb
skos:altLabel	AER (en) Cresta ectodermica apical (es)
OpenAlex ID	wds:Q4779801-9E4E999B-96AF-4BA4-9E29-58196A679004
native label	wds:Q4779801-6D6078D6-E154-47FF-8244-93FE1CEE47D7
Microsoft Academic ID	wds:Q4779801-DF7F36B8-F2CF-4515-BE28-17F9F40D9978
Microsoft Academic ID	https://makg.org/entity/102309675
OpenAlex ID	C102309675
native label	crista ectodermalis apicalis (la)
Microsoft Academic ID	102309675
Terminologia Embryologica	wds:Q4779801-3AF84C9D-AFE8-44F6-8D70-E6AAC4B23B44
Terminologia Embryologica	E5.0.3.0.0.3.4
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q4779801 Apical ectodermal ridge https://es.wikipedia.org/wiki/Cresta_ectod%C3%A9rmica_apical https://fa.wikipedia.org/wiki/%D8%AE%D8%B7%E2%80%8C%D8%A7%D9%84%D8%B1%D8%A3%D8%B3_%D8%A7%DA%A9%D8%AA%D9%88%D8%AF%D8%B1%D9%85%D8%A7%D9%84_%D8%A2%D9%BE%DB%8C%DA%A9%D8%A7%D9%84
is has part(s) of	developing limb
is main subject of	Defect in the maintenance of the apical ectodermal ridge in the Dactylaplasia mouse Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation Fate map of mouse ventral limb ectoderm and the apical ectodermal ridge The limb deformity gene is required for apical ectodermal ridge differentiation and anteroposterior limb pattern formation Retinoic-acid-induced limb malformations resulting from apical ectodermal ridge cell death Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge FGF-2: apical ectodermal ridge growth signal for chick limb development FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb Functions of FGF signalling from the apical ectodermal ridge in limb development Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10. Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse Spatial and temporal patterns of cell death in limb bud mesoderm after apical ectodermal ridge removal Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud The expression pattern of the Distal-less homeobox-containing gene Dlx-5 in the developing chick limb bud suggests its involvement in apical ectodermal ridge activity, pattern formation, and cartilage differentiation The Apical Ectodermal Ridge: morphological aspects and signaling pathways BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Initial limb budding is independent of apical ectodermal ridge activity; evidence from a limbless mutant Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb. Identification of a spatially specific enhancer element in the chicken Msx-2 gene that regulates its expression in the apical ectodermal ridge of the developing limb buds of transgenic mice Development of the apical ectodermal ridge in the chick leg bud and a comparison with the wing bud The expression pattern of the chicken homeobox-containing gene GHox-7 in developing polydactylous limb buds suggests its involvement in apical ectodermal ridge-directed outgrowth of limb mesoderm and in programmed cell death JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions BMPs negatively regulate structure and function of the limb apical ectodermal ridge. BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds. Contribution to the morphometry of limb bud structures in the normodactylous and polydactylous rat. I. Apical ectodermal ridge Recent advances in the study of limb development: the emergence and function of the apical ectodermal ridge A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth The apical ectodermal ridge is a timer for generating distal limb progenitors Localization of HstI transcripts to the apical ectodermal ridge in the mouse embryo Pathogenesis of ectrodactyly in the Dactylaplasia mouse: aberrant cell death of the apical ectodermal ridge Mitogenic property of the apical ectodermal ridge Effects of the apical ectodermal ridge on growth of the versene-stripped chick limb bud Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation. FGF7 and FGF10 directly induce the apical ectodermal ridge in chick embryos Inductive activity and enduring cellular constitution of a supernumerary apical ectodermal ridge grafted to the limb bud of the chick embryo Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb. Retinoic acid application to chick wing buds leads to a dose-dependent reorganization of the apical ectodermal ridge that is mediated by the mesenchyme Posterior apical ectodermal ridge removal in the chick wing bud triggers a series of events resulting in defective anterior pattern formation. A Wnt3a variant participates in chick apical ectodermal ridge formation: distinct biological activities of Wnt3a splice variants in chick limb development Retinoic acid and pattern formation in the developing chick wing: SEM and quantitative studies of early effects on the apical ectodermal ridge and bud outgrowth Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning Early pectoral fin development and morphogenesis of the apical ectodermal ridge in the killifish, Aphyosemion scheeli Formation of extra-digits induced by surgical removal of the apical ectodermal ridge of the chick embryo leg bud in the stages previous to the onset of interdigital cell death Patterns of physiological cell death and mitoses in the apical ectodermal ridge in normodactylous and polydactylous rat limb buds. A quantitative evaluation

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