About: Joseph A. Trapani

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An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

Australian immunologist

Attributes	Values
rdf:type	Item
description	গবেষক (bn) ഗവേഷകൻ (ml) wetenschapper (nl) дослідник (uk) հետազոտող (hy) hulumtues (sq) Australian immunologist (en)
Encyclopedia of Australian Science ID	wds:Q46248485-079535D4-CB78-46D2-9968-A06EAC30C6F2
Encyclopedia of Australian Science ID	P006233b
rdfs:label	Joseph A Trapani (es) Joseph A Trapani (nl) Joseph A Trapani (sl) Joseph A Trapani (ast) Joseph A. Trapani (en)
skos:prefLabel	Joseph A Trapani (es) Joseph A Trapani (nl) Joseph A Trapani (sl) Joseph A Trapani (ast) Joseph A. Trapani (en)
name	Joseph A Trapani (es) Joseph A Trapani (nl) Joseph A Trapani (sl) Joseph A Trapani (ast) Joseph A. Trapani (en)
given name	wds:Q46248485-3f5228e8-4ca7-4559-bce7-de1f33b93518 wds:Q46248485-A932BE86-4AD5-4EC9-8055-5B2CFDDA6CE3
given name	Joseph Albert
instance of	wds:Q46248485-D5611DC3-0943-4F20-A2ED-ADF47B5E701E
instance of	Homo sapiens
award received	wds:Q46248485-18293b82-4aa6-f7e3-5b8a-745637495d4d wds:Q46248485-cdcae53e-483d-016d-2489-c725ea9fa36e
award received	Officer of the Order of Australia Fellow of the Australian Academy of Science
Google Knowledge Graph ID	wds:Q46248485-AB724A91-0183-4799-89D7-90FBC72D2690
Google Knowledge Graph ID	http://g.co/kg/g/11f0mh3_69
Google Knowledge Graph ID	/g/11f0mh3_69
Google Scholar author ID	wds:Q46248485-ec82334f-4d83-14da-dedc-3958fc164f22
Google Scholar author ID	1CskssoAAAAJ
skos:altLabel	Joseph Trapani (en) J. A. Trapani (en) Joseph Albert Trapani (en)
occupation	wds:Q46248485-238C1DFC-C08A-488B-92A6-35E119484803
employer	wds:Q46248485-51895697-4eb0-3f66-3b99-52674554689e wds:Q46248485-b417e6c5-4c01-6d45-ddab-f83059936614
sex or gender	wds:Q46248485-330BB794-6F41-498A-BF5B-BCB782FED58E
country of citizenship	wds:Q46248485-eb2624d8-4a73-6e5b-06ab-b989a683d492
educated at	wds:Q46248485-6dfb24e7-4d17-dfed-ff78-1bd638b257ac
family name	wds:Q46248485-1B32908C-280C-4D03-BA18-5D1C54CCB577
occupation	immunologist
employer	Peter MacCallum Cancer Centre University of Melbourne
sex or gender	male
country of citizenship	Australia
educated at	University of Melbourne
family name	Trapani
ORCID iD	wds:Q46248485-FD804981-8C31-4AAC-A9A2-7DAC30765FCB
Dimensions author ID	wds:Q46248485-EAD09490-E048-41DD-B228-AFC9593381BD
ORCID iD	https://orcid.org/0000-0003-0983-1532
ORCID iD	0000-0003-0983-1532
Dimensions author ID	01264555113.03
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q46248485 Joseph Trapani (immunologist)
is author of	The MACPF/CDC family of pore-forming toxins Type I IFNs enhance the terminal differentiation of dendritic cells Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis Chimeric (mouse/human) anti-colon cancer antibody c30.6 inhibits the growth of human colorectal cancer xenografts in scid/scid mice. The use of chimeric human Fc(epsilon) receptor I to redirect cytotoxic T lymphocytes to tumors The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy Assaying cytochrome C translocation during apoptosis Infective, neoplastic, and homeostatic sequelae of the loss of perforin function in humans Suppression of lymphoma and epithelial malignancies effected by interferon gamma The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32 A fresh look at tumor immunosurveillance and immunotherapy. Expression of IFI 16 in epithelial cells and lymphoid tissues. Adoptive transfer: The role of perforin in mouse cytotoxic T lymphocyte rejection of human tumor xenografts in vivo hScrib is a functional homologue of the Drosophila tumour suppressor Scribble A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro. Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing Perforin-mediated target-cell death and immune homeostasis The Interferon Inducible Autoantigen, IFI 16: Localization to the Nucleolus and Identification of a DNA-Binding Domain Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth. The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity. Cloning and characterisation of Ifi206: a new murine HIN-200 family member Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction Granzyme M mediates a novel form of perforin-dependent cell death Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo. Functional significance of the perforin/granzyme cell death pathway The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations The human interferon-inducible protein, IFI 16, is a repressor of transcription Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression HIN-200: a novel family of IFN-inducible nuclear proteins expressed in leukocytes.

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