About: Christopher Overall

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researcher

Attributes	Values
rdf:type	Item
description	forskare (sv) ikertzailea (eu) researcher (en) 연구원 (ko) গবেষক (bn) 研究者 (ja) ഗവേഷകൻ (ml) wetenschapper (nl) дослідник (uk) باحت (ary) изилдөөчү (ky) 研究者 (zh) հետազոտող (hy) hulumtues (sq)
rdfs:label	Christopher Overall (en) Christopher Overall (es) Christopher Overall (nl) Christopher Overall (sl) Christopher Overall (ast)
skos:prefLabel	Christopher Overall (en) Christopher Overall (es) Christopher Overall (nl) Christopher Overall (sl) Christopher Overall (ast)
name	Christopher Overall (en) Christopher Overall (es) Christopher Overall (nl) Christopher Overall (sl) Christopher Overall (ast)
given name	wds:Q42843211-6D8E340C-A298-4E9E-AB7C-E7D58F999226
given name	Christopher
instance of	wds:Q42843211-4F2121E9-A334-45B8-9F61-191EACE81E48
instance of	Homo sapiens
occupation	wds:Q42843211-3DA7FD9F-E483-4BF8-8F6D-BB67B444DBFA
sex or gender	wds:Q42843211-F713F7B9-E657-44EA-BBF6-8EDCA350FDD7
VIAF ID	wds:Q42843211-22920b20-5485-446c-bb15-54075ad38787
family name	wds:Q42843211-28070FE9-5042-4B7D-9539-A1A79FA77883
Canadiana Name Authority ID	wds:Q42843211-45168553-C0CA-4002-B7C8-1884405397D8
VIAF ID	http://viaf.org/viaf/105499693
occupation	researcher
sex or gender	male
VIAF ID	105499693
family name	Overall
Canadiana Name Authority ID	ncf10319968
ORCID iD	wds:Q42843211-7B80B9B6-A734-4A4C-A378-904466FF3B87
ORCID iD	https://orcid.org/0000-0001-6404-5521
ORCID iD	0000-0001-6404-5521
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q42843211
is author of	Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8 The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Conne Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice A time-course comparative microarray analysis of an incompatible and compatible response by Glycine max (soybean) to Heterodera glycines (soybean cyst nematode) infection Human and mouse proteases: a comparative genomic approach Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics In search of partners: linking extracellular proteases to substrates Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B. Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3' subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond Protease yoga: extreme flexibility of a matrix metalloproteinase Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts. Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical. Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage. Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in c Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity Stromal regulation of vessel stability by MMP14 and TGFbeta The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites Matrix metalloproteinase proteomics: substrates, targets, and therapy. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo Protease degradomics: a new challenge for proteomics Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics Mannose-binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: potential role in human MBL deficiency ArrayInitiative - a tool that simplifies creating custom Affymetrix CDFs Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome. Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

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