About: Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor.

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About: Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor. Goto Sponge NotDistinct Permalink

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scientific article published on 21 August 2015

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rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) article scientific (oc) articol științific (ro) articolo scientifico (it) artigo científico (gl) artigo científico (pt) artigo científico (pt-br) artikull shkencor (sq) artikulong pang-agham (tl) artykuł naukowy (pl) bilimsel makale (tr) scienca artikolo (eo) teaduslik artikkel (et) tieteellinen artikkeli (fi) tudományos cikk (hu) vedecký článok (sk) vetenskaplig artikel (sv) vitenskapelig artikkel (nb) vitskapeleg artikkel (nn) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) επιστημονικό άρθρο (el) научна статия (bg) научная статья (ru) научни чланак (sr) מאמר מדעי (he) სამეცნიერო სტატია (ka) บทความทางวิทยาศาสตร์ (th) artikel ilmiah (id) bài báo khoa học (vi) naučni članak (sr-el) мақолаи илмӣ (tg-cyrl) научни чланак (sr-ec) article scientifique (fr) 2015 nî lūn-bûn (nan) 2015年の論文 (ja) 2015년 논문 (ko) наукова стаття, опублікована в серпні 2015 (uk) 2015年論文 (zh-hk) 2015年論文 (zh-tw) 2015年論文 (zh-hant) 2015年論文 (yue) 2015年論文 (zh-mo) 2015年论文 (zh) 2015年论文 (zh-cn) 2015年论文 (zh-sg) 2015年论文 (zh-hans) 2015年论文 (wuu) 2015年论文 (zh-my) artículo científico publicado en 2015 (es) artículu científicu espublizáu en 2016 (ast) 2016 ജനുവരി 1 നു പ്രസിദ്ധീകരിച്ച ശാസ്ത്ര ലേഖനം (ml) scientific article published on 21 August 2015 (en) scientific article published on 21 August 2015 (en-ca) scientific article published on 21 August 2015 (en-gb) ২১ আগস্ট ২০১৫-এ প্রকাশিত বৈজ্ঞানিক নিবন্ধ (bn) مقالة علمية نشرت في 21 أغسطس 2015 (ar)
publication date	wds:Q40621433-B851CDD6-8DAD-41A0-B53D-E17EA2BABC8A
publication date	2016-01-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q40621433-8FDB4F65-97D9-485C-96DC-0D7613604A71
language of work or name	English
cites work	wds:Q40621433-0A7D1085-71F4-41BB-BEAC-31D53D6077AE wds:Q40621433-0ECE24E3-7B6D-47FC-8108-C196CEB8DDD3 wds:Q40621433-17048711-327A-4C6D-805E-79E5A8B6D306 wds:Q40621433-29C0846F-2173-48BE-BB25-16CCD1099410 wds:Q40621433-4CBBD163-6A19-4839-ADDF-9FCD4D3264A0 wds:Q40621433-7D895052-1C0D-4F6D-BE0C-2446220F836D wds:Q40621433-7F036A8A-6964-4AE6-839C-1BB242DBDFB6 wds:Q40621433-8DF9F1E8-C37B-4EDD-818F-FDC5AB4A4E54 wds:Q40621433-A4C688CD-72B4-4243-B84E-03FFB6CA14C5 wds:Q40621433-AC5235A2-074A-4950-8E8D-943FE22227D0 wds:Q40621433-B5490D90-CDDF-4A87-AF1F-CFFA29ED21B0 wds:Q40621433-C2E949E4-7EA1-4C84-A505-6B21BC253CEB wds:Q40621433-DF9F9779-55DA-4630-8286-931649BEE52E
cites work	Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity Synopsis of some recent tactical application of bioisosteres in drug design Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells Oxetanes as versatile elements in drug discovery and synthesis A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization Quantitative ADME proteomics - CYP and UGT enzymes in the Beagle dog liver and intestine Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors
author name string	wds:Q40621433-0F22C80E-523B-48FA-B4D7-D3D3F138D2B4 wds:Q40621433-3874BA2C-68BC-413F-B382-BFC2E9209DE9 wds:Q40621433-590898D5-ECBB-40BA-B6DD-9D8CA6F7B34D wds:Q40621433-674206E3-27A6-41FF-B036-466E64C0856D wds:Q40621433-67ABF90F-D756-4C68-AD16-4F4D53662528 wds:Q40621433-6A28FCA8-9C3F-4CB2-B317-FD199E17894D wds:Q40621433-7C557C37-FD15-48BB-87A3-3D54333376A8 wds:Q40621433-A931E268-2700-4417-A47E-AAB1998EA3A8 wds:Q40621433-EE7505F2-D469-4F24-A67F-AE7BAF681E73
author name string	Robert A Copeland

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