About: Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA.

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About: Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. Goto Sponge NotDistinct Permalink

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scientific article published on 26 October 2010

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rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2010 (ast) наукова стаття, опублікована в жовтні 2010 (uk) مقالة علمية نشرت في 26 أكتوبر 2010 (ar) scientific article published on 26 October 2010 (en)
publication date	wds:Q37803300-A6207CA6-C702-482D-AEC6-89C3FAEA867F
publication date	2010-10-26 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37803300-D589A11B-114E-4F55-9B6A-B2A2B9D8EC66
language of work or name	English
cites work	wds:Q37803300-1671D04C-957D-43A9-A36F-37C877798A43 wds:Q37803300-1B97D1C0-F2C5-4688-BABE-4E76C6023277 wds:Q37803300-2BC5D489-D2A8-457C-A108-A414E0D24041 wds:Q37803300-2D5AD0F9-2AC9-466D-BC89-B0E34A51B345 wds:Q37803300-334DD848-EB76-4172-92A0-A06FF7CD9D51 wds:Q37803300-3A288D79-5625-4320-B257-75A527C4D290 wds:Q37803300-3D5F1881-FF3D-4716-AD18-F9B370CC3AE3 wds:Q37803300-422DF71F-C1E9-4406-95FC-CD176596DBCA wds:Q37803300-478E1F4F-198E-410C-8018-9D6D94105504 wds:Q37803300-4A2BF984-720C-4E91-9681-A6AEB866EEA8 wds:Q37803300-51896481-39C1-41F1-8166-05E9B0956C83 wds:Q37803300-55B8AF38-DFF2-429B-84DA-0F30E719CCD6 wds:Q37803300-56F1B0F9-FF76-4D10-9C77-827FBCE751EA wds:Q37803300-58A3CD78-4610-47BD-834F-BCC3212BD7F6 wds:Q37803300-6A13BD2D-6715-4EFE-9C75-37088643DA62 wds:Q37803300-9DD28760-972D-469F-BA08-07525826E3AD wds:Q37803300-B35F7F58-2F9D-4B53-806C-CAD07D422ACB wds:Q37803300-C7D23844-316C-49EF-9CBE-6941F974FD31 wds:Q37803300-D323A98E-BAB3-487A-826D-5C8599C3305C wds:Q37803300-D98AB44C-18C3-408F-B0AC-9542C8FA8929 wds:Q37803300-DB04AC3B-390D-4CD0-A2A8-E339977E9034 wds:Q37803300-DCB57BD1-AB5F-445C-81A6-5F2A87C6B83B wds:Q37803300-E60CC3E9-4B12-4AFC-9408-8080FFCEB526 wds:Q37803300-F1E5C991-4CCD-44C6-8C24-E7648A6194A9 wds:Q37803300-F5AF91C6-17AA-4741-A37E-B8531C7E8432 wds:Q37803300-FB09FFEE-59F4-4E09-BAD5-C1792868CC0F wds:Q37803300-FF2A2E70-5684-4C47-B41B-76D3E4CB1756
cites work	Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches The interplay between MYC and HIF in cancer. Quantitative proteomic analysis of Myc oncoprotein function Alternative isoform regulation in human tissue transcriptomes Integration of external signaling pathways with the core transcriptional network in embryonic stem cells Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing The gene encoding the splicing factor SF2/ASF is a proto-oncogene Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins) Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell line. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells Pyruvate kinase M2 is a phosphotyrosine-binding protein On the Origin of Cancer Cells The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth Downstream targets of heterogeneous nuclear ribonucleoprotein A2 mediate cell proliferation Pyruvate kinase type M2 and its role in tumor growth and spreading Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines. Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing Multiple and specific mRNA processing targets for the major human hnRNP proteins Temporally distinctive changes of alternative splicing patterns during myogenic differentiation of C2C12 cells
author name string	wds:Q37803300-2549B827-E1CC-4E31-A869-D0210FBD3F06
author name string	Mo Chen
rdfs:label	Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (en) Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (nl) Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (ast)
skos:prefLabel	Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (en) Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (nl) Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (ast)
name	Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (en) Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (nl) Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. (ast)
author	wds:Q37803300-1747431C-DD16-4905-8790-C9BFD716A4F4 wds:Q37803300-F4235BB1-7DC3-4BFA-B63C-08064CD34960
author	James L. Manley Jian Zhang
title	wds:Q37803300-20E6BBA7-D0CF-44DE-8EC6-3BAB8255D6A5
title	Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA (en)
page(s)	wds:Q37803300-FF784509-9B9F-4374-9BEE-8D35BADD0D15
page(s)	8977-8980
instance of	wds:Q37803300-80CDB0A6-8DC3-42E5-AD8E-15313CFC43EC
instance of	scholarly article
main subject	wds:Q37803300-C3B50EE6-46B2-43DF-B137-FFE5CA26F2FE
main subject	alternative mRNA splicing, via spliceosome
PubMed ID	wds:Q37803300-B1E5FC2C-7E4A-4FEB-BB80-3AFE8E71918B
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20978194

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