About: Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia.

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About: Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. Goto Sponge NotDistinct Permalink

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scientific article published on 06 February 2013

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2013 (ast) наукова стаття, опублікована в лютому 2013 (uk) scientific article published on 06 February 2013 (en) مقالة علمية نشرت في 06 فبراير 2013 (ar)
publication date	wds:Q37576591-C3753D3B-CA58-40A9-8168-6C037071DD94
publication date	2013-02-06 00:00:00Z (xsd:dateTime)
exact match	wds:Q37576591-10B573E5-9986-494D-AA08-DD68BF66F836
exact match	https://scigraph.springernature.com/pub.10.1038/leu.2013.37
cites work	wds:Q37576591-0AF21EDB-2100-48B1-95EA-88D80710ABBF wds:Q37576591-14FCFA4E-AB28-4846-AC6D-92C05F6A6DEE wds:Q37576591-3AC572A8-1510-4CC4-8D0D-8F8C835803A1 wds:Q37576591-56C10AF5-3242-4A1A-B593-D002E08017D9 wds:Q37576591-58387E40-D322-4AC9-95A0-A6FBAA8C7CF6 wds:Q37576591-5BF24BC7-0E95-4615-9FC8-E705CF331C7D wds:Q37576591-89FE123E-A62A-40D1-9B19-8F16F913E302 wds:Q37576591-8C7B91AE-9C16-4C3F-B9B4-B9AC60BAF272 wds:Q37576591-9A402865-40CB-42F0-AC6C-2D3E713A431D wds:Q37576591-B4C01D73-3217-429F-B0F3-BFC324657251 wds:Q37576591-CD727DC2-4F83-4365-901F-B0DCF8DD96F6 wds:Q37576591-EB45F239-51A7-4C3F-85E7-2E6A709B0F12 wds:Q37576591-EF8F4B3E-E9FC-4999-A171-DC17054E7C50 wds:Q37576591-F26C28C3-AFCA-4B18-B570-B5F7DE3CE3ED wds:Q37576591-F30949EB-B045-4F6E-8167-DDBF7F1D63D9
cites work	Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Chronic lymphocytic leukemia Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells CD38 signal transduction in human B cell precursors. Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and phosphatidylinositol 3-kinase ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia
author name string	wds:Q37576591-0DD510EA-473D-4005-8CEF-DCE2A0632A99 wds:Q37576591-231650C8-3509-49B9-B9F9-F1A36A311013 wds:Q37576591-B2C448A7-859F-4B52-8F81-5AA8C717982C wds:Q37576591-CD5945E9-74F3-4763-937F-265FE06AF7B0
author name string	D Liu A Wiestner S E M Herman J W Friedberg
rdfs:label	Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. (en) Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. (nl) Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. (ast)
skos:prefLabel	Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. (en) Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. (nl) Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. (ast)
name	Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. (en) Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. (nl) Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia. (ast)
author	wds:Q37576591-1C13EF52-6673-4B4B-B27B-B9E5A6A8B808 wds:Q37576591-2DF3F875-D38C-494E-AFD1-8D1C42741ECD
author	Paul M Barr Erin M McAuley
title	wds:Q37576591-FDB8F7CB-C1E8-47BD-BF43-100694413891
title	Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia (en)
page(s)	wds:Q37576591-B0E76240-9881-4008-B8A2-C82622CDB930
page(s)	1769-1773
instance of	wds:Q37576591-ADE29398-5653-40FA-9238-3DDB42E5B06B
instance of	scholarly article
main subject	wds:Q37576591-2E146FC7-EB86-4063-89E1-D97B7AFE471F wds:Q37576591-35C1FAEE-91AA-4810-8270-2DE12894C844
main subject	leukemia lymphocyte
PubMed ID	wds:Q37576591-3448BB31-E5E1-4AD5-964A-4D82172FE4DF
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23385377
PubMed ID	23385377
published in	wds:Q37576591-375312A9-C24A-47D8-BC6E-140286D4C753
published in	Leukemia
issue	wds:Q37576591-D623FE8D-7C88-4417-A6C1-6A803094B103
volume	wds:Q37576591-5E6EA546-2692-4DEF-AEE2-2646A375380C
issue	8
volume	27
DOI	wds:Q37576591-4A89BCCA-80FA-4F15-86DB-E3747E21BADA
DOI	http://dx.doi.org/10.1038/LEU.2013.37
DOI	10.1038/LEU.2013.37
ResearchGate publication ID	wds:Q37576591-7BBC3F09-4D0E-49DB-B2D1-E4935F13B2E9
ResearchGate publication ID	235405200
PMCID	wds:Q37576591-0DDD9FF7-8B4F-48EF-8986-6282187307CA
PMCID	3920486
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q37576591
is cites work of	B-cell receptor signaling as a driver of lymphoma development and evolution

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