About: Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels

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About: Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels Goto Sponge NotDistinct Permalink

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scientific article published on 14 April 2008

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2008 (ast) наукова стаття, опублікована у квітні 2008 (uk) مقالة علمية نشرت في 14 أبريل 2008 (ar) scientific article published on 14 April 2008 (en)
publication date	wds:Q37358879-8A21DAE8-B10F-46D6-9CF8-9264DC44A507
publication date	2008-04-14 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37358879-1FC9C2CB-5A62-4EC6-97E0-0B5C0BC1D6BE
language of work or name	English
cites work	wds:Q37358879-015BFEC0-FD5F-4ECE-8DAA-CB5C9D10F38F wds:Q37358879-0737EB51-9446-45A7-8350-1EDEF0F1188A wds:Q37358879-0B80BC3C-D249-4B03-B715-12567BF907AA wds:Q37358879-14141859-B7B5-4963-98A1-6C30F1E8E27B wds:Q37358879-16F986D9-1060-4DEF-A46B-BF5C0096E9E9 wds:Q37358879-22387A72-DEE1-44EB-8648-B3832E7C721E wds:Q37358879-3AA2858C-9CA3-4C0C-8926-6D2BB9F4985C wds:Q37358879-3AC200E7-C75B-406E-8636-7DBB988272E9 wds:Q37358879-4161CF7D-238A-42A0-B7AD-453CC55965BD wds:Q37358879-418D6DEC-49E2-4296-B84E-2062A1BBE642 wds:Q37358879-49448731-D83A-4EB7-A781-794DB07875E2 wds:Q37358879-4F11B3E0-0D1E-4E6E-9563-5628DC5D3BA4 wds:Q37358879-5B556493-CF4F-45F3-9E5E-846AF822C7AF wds:Q37358879-662F58F8-744A-4D96-ACC9-ECECFD97E55C wds:Q37358879-675A508B-E286-4D91-8AC1-1D0CAD807F76 wds:Q37358879-70F0D66C-18F2-4C92-801B-5FBCD259CFF0 wds:Q37358879-811B2B31-771C-454C-8A70-C9A3C8F337A3 wds:Q37358879-81C64E42-3B2C-4032-BB9A-9797E28C7157 wds:Q37358879-83A52F46-9D04-4423-A170-88380DB26E3C wds:Q37358879-9B3CBFDC-2792-4AD7-BEA7-FCE61AA83F29 wds:Q37358879-9C9F40AC-8230-4B57-9C48-1AB43ADD1E18 wds:Q37358879-A7F38B8F-FB1B-4A46-B082-E0329435FF85 wds:Q37358879-B006A360-6AD4-46FD-88B6-2924A540AEA8 wds:Q37358879-B460E378-16CD-4D99-AE25-4792C546689E wds:Q37358879-B4CBAD9E-E535-44F6-836E-0EF2A08278CF wds:Q37358879-B68A5221-5B58-4974-8EB4-0821D143AA62 wds:Q37358879-B7F853AE-5433-4FC3-A0B2-3B0D899B2A67 wds:Q37358879-D3B5FC4E-04BE-410D-9C87-EF6C63D2FB89 wds:Q37358879-D6BD3C34-303C-4C30-BABB-55A723591526 wds:Q37358879-E4A25617-4A10-4541-9404-2C5C37C930F0 wds:Q37358879-ED139BC1-09E1-432F-95A8-7CFC0A912560 wds:Q37358879-EE530D93-2CA8-4811-A34F-0AF19A09341E wds:Q37358879-EF0D12F9-7059-4247-9789-0887FD58B88D wds:Q37358879-F51A4BA9-F407-4B25-A6BF-0B436F7A0009 wds:Q37358879-FFB0092F-3F5C-4BC4-AADF-ADC62486B096
cites work	A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome Schistosoma mansoni infection in eosinophil lineage-ablated mice An etiological role for aeroallergens and eosinophils in experimental esophagitis IL-5 promotes eosinophil trafficking to the esophagus. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. In vivo administration of antibody to interleukin-5 inhibits increased generation of eosinophils and their progenitors in bone marrow of parasitized mice. Eosinophil trafficking in allergy and asthma. Interleukin-5, eosinophils, and disease Treatment of patients with the hypereosinophilic syndrome with mepolizumab Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. Idiopathic eosinophilic esophagitis is associated with a TH2-type allergic inflammatory response Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome The eosinophil Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model Abnormal Clones of T Cells Producing Interleukin-5 in Idiopathic Eosinophilia Eosinophilic gastrointestinal disorders (EGID). Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways Detection of interleukin-5 messenger RNA in Reed-Sternberg cells of Hodgkin's disease with eosinophilia Safety and efficacy of the monoclonal anti-interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti–IL-5 antibody SCH55700 Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome Receptor internalization is required for eotaxin-induced responses in human eosinophils Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys. Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells Use of an Anti–Interleukin-5 Antibody in the Hypereosinophilic Syndrome with Eosinophilic Dermatitis Internalization, lysosomal degradation and new synthesis of surface membrane CD4 in phorbol ester-activated T-lymphocytes and U-937 cells Tumor-promoting phorbol esters selectively abrogate the expression of the T4 differentiation antigen expressed on normal and malignant (Sézary) T helper lymphocytes
author name string	wds:Q37358879-19E51686-201C-4F8D-9B58-D2BC28CC186F wds:Q37358879-239FF542-7B06-4281-BC97-DA5CE71CC7DD wds:Q37358879-4D1E5EC3-688A-4B72-A49B-92869A7223A0 wds:Q37358879-656FEA20-B628-45F6-9FAB-86FB03F06EC1 wds:Q37358879-86DE19A8-4ACF-4089-B7C2-953789941F03 wds:Q37358879-C9ECCD3D-7247-49B9-91A7-6CE62F424255 wds:Q37358879-F8C03238-88E8-4F79-AEA4-20C1C034ED87
author name string	Marc E Rothenberg Yoshiyuki Yamada

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