About: Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity

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About: Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity Goto Sponge NotDistinct Permalink

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scientific article published on August 1996

Attributes	Values
rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 1996 (ast) наукова стаття, опублікована в серпні 1996 (uk) مقالة علمية نشرت في أغسطس 1996 (ar) scientific article published on August 1996 (en)
publication date	wds:Q37358027-BE0E30DA-22E5-4161-8022-234908B8AADB
publication date	1996-08-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37358027-A9610100-A3DE-472F-9E36-8F3CA7C89549
language of work or name	English
cites work	wds:Q37358027-14C64C0C-4211-48FB-962F-AEB87CEC38F7 wds:Q37358027-173EB5B9-2756-4CF8-830C-D7795191505D wds:Q37358027-1A484DFF-201C-4FCD-B95B-AEB861FE5C63 wds:Q37358027-28D1DD76-2085-48B8-A4DA-F2FDD0425EA7 wds:Q37358027-2972337D-4D26-45A1-AE66-45833BF1348A wds:Q37358027-33E52E13-CEEA-48F9-B1DF-3B5917E7CD26 wds:Q37358027-391C863F-B76D-4705-A694-EE251D5ECEFE wds:Q37358027-44F61165-ADDB-4BAA-A889-AD86C63CE5E2 wds:Q37358027-48AA3748-C70A-4091-A87E-8DC6FAD10EE0 wds:Q37358027-62F55C6C-DF1B-4AC6-B12A-2D17CE07D4FE wds:Q37358027-867DE21C-6952-488B-B480-DF6EA91F576D wds:Q37358027-91D1459C-B18E-4FE9-88FB-82A99964994C wds:Q37358027-ABC6E42B-8618-4CFC-91A4-916865E938E5 wds:Q37358027-AD94A8C4-94EC-46B1-B59A-3EA759FC4313 wds:Q37358027-B6C4C07B-2B99-4C75-A2CF-83ECE21A6BC6 wds:Q37358027-B89E5FF1-E96E-448B-B773-01A78941F48D wds:Q37358027-BC46D865-57B9-46F7-B1CF-4D2314FF7D00 wds:Q37358027-BC8E89A3-3E0D-4A81-BA2A-616D76AB44D1 wds:Q37358027-CF152E6B-FC52-4C9A-A50A-FC0F41823973 wds:Q37358027-DB1F3355-6269-495A-9F11-64F0ABC24950 wds:Q37358027-DBE66D25-3850-471F-B38F-D57D8904BA69 wds:Q37358027-DD83F511-7ECE-442E-AA79-21F91706CCFA wds:Q37358027-E1E3FA37-8178-4E12-AB94-0431A5F2AED9 wds:Q37358027-FB3E557A-6185-4B76-8B04-6164D13DB9B2 wds:Q37358027-FE8F2EB1-646D-4353-9BB8-AEBE38AB5340
cites work	Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity A base substitution at a splice site in the COL3A1 gene causes exon skipping and generates abnormal type III procollagen in a patient with Ehlers-Danlos syndrome type IV. Exon recognition in vertebrate splicing Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy. Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome Dihydropyrimidine dehydrogenase deficiency leading to thymine-uraciluria. An inborn error of pyrimidine metabolism Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea. Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients Elevated urine, blood and cerebrospinal fluid levels of uracil and thymine in a child with dihydrothymine dehydrogenase deficiency Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction Exon definition may facilitate splice site selection in RNAs with multiple exons GT to AT transition at a splice donor site causes skipping of the preceding exon in phenylketonuria Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy Severe fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles Analysis of the dihydropyrimidine dehydrogenase polymorphism in a British population Combination clinical trials with thymidine and fluorouracil: a phase I and clinical pharmacologic evaluation Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency Correlation between catalytic activity and protein content for the polymorphically expressed dihydropyrimidine dehydrogenase in human lymphocytes. Dihydropyrimidine dehydrogenase deficiency leading to thymine-uraciluria. An inborn error of pyrimidine metabolism Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil (review).
author name string	wds:Q37358027-0AA64461-47D8-4ACC-817A-9DA841D506B2 wds:Q37358027-1913D4D6-25D5-42FE-AA81-B208CF070998 wds:Q37358027-32E2672C-A933-4C37-9EC9-D21AE2D1B633 wds:Q37358027-71FFD554-D9D2-454E-B623-899C6EDB4136 wds:Q37358027-7C5E6F9F-45DC-43D6-A0FE-C83058C340D2
author name string	F J Gonzalez H L McLeod P Fernandez-Salguero X Wei J McMurrough
rdfs:label	Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (en) Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (nl) Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (ast)
skos:prefLabel	Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (en) Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (nl) Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (ast)
name	Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (en) Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (nl) Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (ast)
title	wds:Q37358027-59DAB097-38DA-4009-AC00-E56CEC25CFBC
title	Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity (en)
page(s)	wds:Q37358027-4A82F212-5AD3-4710-B1DE-D9EC5AC87F8B
page(s)	610-615
instance of	wds:Q37358027-E4CC07E1-84A0-4E90-8806-190F1EA41056
instance of	scholarly article
main subject	wds:Q37358027-B0E46C32-6F29-4BDD-B124-42EA3647225A wds:Q37358027-C0E9E843-233A-4CD3-9773-D5DFF0793AD7
main subject	wd:Q238512 dihydropyrimidine dehydrogenase deficiency

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