About: Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression

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About: Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression Goto Sponge NotDistinct Permalink

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scientific article published on 10 October 2008

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rdf:type	Item
description	videnskabelig artikel (da) article científic (ca) articolo scientifico (it) artigo científico (pt) bilimsel makale (tr) vedecký článok (sk) vetenskaplig artikel (sv) vědecký článek (cs) wetenschappelijk artikel (nl) wissenschaftlicher Artikel (de) научни чланак (sr) article scientifique (fr) artículu científicu espublizáu en 2008 (ast) наукова стаття, опублікована в жовтні 2008 (uk) 2008 թվականի հոկտեմբերի 10-ին հրատարակված գիտական հոդված (hy) scientific article published on 10 October 2008 (en) مقالة علمية نشرت في 10 أكتوبر 2008 (ar)
publication date	wds:Q37015016-B269FE98-E9BF-41E3-8082-3E9820119FA0
publication date	2008-10-10 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q37015016-366B1588-E5A6-4C38-8FC0-1DDD636ED9F1
language of work or name	English
cites work	wds:Q37015016-064BB32A-F2BE-43F1-8C59-ED94251476F8 wds:Q37015016-0CC458E7-F353-48AD-917E-FFA0FB01F297 wds:Q37015016-10AE449F-1A26-4A37-840F-63DC8799107E wds:Q37015016-1188C41B-4F1E-4B6C-B1C6-57163C8DAFF6 wds:Q37015016-17592D95-C7A7-41B9-A725-8B752E15F7E6 wds:Q37015016-20F90CDD-C68D-44D2-9F92-39E5A425C343 wds:Q37015016-2244B3E4-3C7C-4CAF-84F4-D96C06BA8368 wds:Q37015016-2CFD3802-F195-4C37-BBB7-3A4FEFBFF84A wds:Q37015016-2D83B51C-54EE-492C-A890-6EE8D5A1D7BE wds:Q37015016-3798ADC7-2B08-450F-A679-7BA76829D262 wds:Q37015016-3D08015C-461C-4E50-9BA9-46FFB24849F5 wds:Q37015016-42AB6081-981E-46A6-AC58-A3D6B29D1638 wds:Q37015016-42F36B6B-05DF-4A02-B76F-4AB37F23A2F0 wds:Q37015016-485C214E-5FAB-40F9-AA04-FF7B09991DB1 wds:Q37015016-4C13C0BE-B21C-4799-8485-019AA1717672 wds:Q37015016-589DBF67-4958-49BC-8B84-69B49C1FC4AA wds:Q37015016-69806F9B-166D-4825-93CA-AFB646C50911 wds:Q37015016-79A0634E-FB9E-41A6-B609-820DACEFC312 wds:Q37015016-8534956F-ED0F-4FB2-9FB5-F539D4BD5CF9 wds:Q37015016-870C301B-FBF9-4C7B-8C0C-2E27B9F750E2 wds:Q37015016-9A486A1D-140C-4685-98B2-B1817E57679C wds:Q37015016-9B08D4EA-A25F-40DA-9B72-944FBA0A742E wds:Q37015016-9D82D2A0-5675-4D06-9BCD-B6D2E05A0777 wds:Q37015016-9F718334-5882-4C2A-879F-653A051D009F wds:Q37015016-A5E1EC71-DD72-4D4A-85FB-89CB4BF6F828 wds:Q37015016-A8AE01BF-1B48-45C4-9B88-5242BB00F8E9 wds:Q37015016-B76CE870-9E3A-4389-844A-9BF975073860 wds:Q37015016-C9309193-1FF5-443B-9D29-5B1926CE978D wds:Q37015016-D4A7D1D9-9DB7-45BA-BFA5-9C76AEC9CC37 wds:Q37015016-D7942315-CFC4-4C3A-B601-E6D92D4F20E7 wds:Q37015016-DA2C9066-CFAD-451E-B276-3AA75F5CDBCE wds:Q37015016-E7B23C40-79CE-45B1-A1AB-74C088587FAB wds:Q37015016-EAD6D2E1-75F3-4821-92D0-E568931D77A8 wds:Q37015016-F6BB2A9B-A580-4063-998C-7A3C6022A41B
cites work	Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. An aminopeptidase activity in bovine pituitary secretory vesicles that cleaves the N-terminal arginine from beta-lipotropin60-65. Neuropeptide processing profile in mice lacking prohormone convertase-1. Precursor convertases in the secretory pathway, cytosol and extracellular milieu Proteolytic processing in the secretory pathway Induction of integral membrane PAM expression in AtT-20 cells alters the storage and trafficking of POMC and PC1. Carboxypeptidase E Processing and activation of lysosomal proteinases Corticotropin releasing factor stimulates adrenocorticotropin and β-endorphin release from AtT-20 mouse pituitary tumor cells Corticotropin-releasing factor stimulates phospholipid methylation and corticotropin secretion in mouse pituitary tumor cells Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L. Proteases for processing proneuropeptides into peptide neurotransmitters and hormones Melanocortin system and eating disorders Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective prohormone convertase 2. The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study. Peripheral beta-endorphin and pain modulation Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo Characterization of pro-opiocortin-converting activity in purified secretory granules from rat pituitary neurointermediate lobe Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Pathophysiological dynamics of human ovarian surface epithelial cells in epithelial ovarian carcinogenesis Complete structure of the porcine pro-opiomelanocortin mRNA derived from the nucleotide sequence of doned cDNA Purification and characteristics of the candidate prohormone processing proteases PC2 and PC1/3 from bovine adrenal medulla chromaffin granules Physiology of beta-endorphins. A close-up view and a review of the literature Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion Secretory vesicle aminopeptidase B related to neuropeptide processing: molecular identification and subcellular localization to enkephalin- and NPY-containing chromaffin granules Unique cleavage specificity of 'prohormone thiol protease' related to proenkephalin processing Regulation of cellular alpha-MSH and beta-endorphin during stimulated secretion from intermediate pituitary cells: involvement of aspartyl and cysteine proteases in the control of cellular levels of alpha-MSH and beta-endorphin Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH.
author name string	wds:Q37015016-06954739-12A8-4F2B-86B3-9A141ED64A0B wds:Q37015016-50956B98-D73A-415E-9244-96CF33453C4E wds:Q37015016-638C5426-99FE-472C-A5B5-857D69049EF0 wds:Q37015016-6EC13F46-EB3F-49AA-8434-6A53053AD8A2 wds:Q37015016-D3F8B3A5-649D-4796-BEE2-65EEFC7FE3D2 wds:Q37015016-DFA8DF42-19BE-452C-BB06-A03E32BE2028 wds:Q37015016-FA948E42-9506-497B-A644-53FFC4D86A02
author name string	Christoph Peters Vivian Hook Thomas Toneff

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