About: Role of CHK2 in cancer development

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About: Role of CHK2 in cancer development Goto Sponge NotDistinct Permalink

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description	2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած (hyw) 2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված (hy) artículu científicu espublizáu en 2008 (ast) vědecký článek publikovaný v roce 2008 (cs) наукова стаття, опублікована у вересні 2008 (uk) مقالة علمية (نشرت في سبتمبر 2008) (ar) vedecký článok (publikovaný 2008/09/01) (sk) wetenschappelijk artikel (gepubliceerd op 2008/09/01) (nl) im September 2008 veröffentlichter wissenschaftlicher Artikel (de) scientific journal article (en)
publication date	wds:Q28611402-F4DFA395-5CFF-4C9E-8730-1F28A1E76DC6
publication date	2008-09-01 00:00:00Z (xsd:dateTime)
exact match	wds:Q28611402-54A9FD8D-727E-41D9-9A46-EF1FA31F1CF3
exact match	https://scigraph.springernature.com/pub.10.1007/s12094-008-0248-5
cites work	wds:Q28611402-003054DA-3403-4F2A-9162-044EFE03AE48 wds:Q28611402-00D8C2F6-E165-449D-88BF-317B6EEF83A3 wds:Q28611402-015DB05F-B554-4F60-88C8-F1A7657818B1 wds:Q28611402-031E8DBC-4AAF-4130-842D-C46F6586B669 wds:Q28611402-0B023C5C-136B-4998-BF40-3BFE050F6BBF wds:Q28611402-1ECFAA3A-0362-4075-B973-1E7FE5E3735C wds:Q28611402-3369D98E-24FD-4190-BDEB-350D3BB5E7C0 wds:Q28611402-3C691A14-5E55-472A-8A15-E5852D39A3FC wds:Q28611402-429CB1B9-02CE-420A-A8CA-755353BA3C87 wds:Q28611402-53FD1E94-06FA-4D5B-A53B-5C165E01FD53 wds:Q28611402-5B9DF637-F41F-476A-A89B-7F46FF198562 wds:Q28611402-5BB95923-2257-4953-A020-AB0D8CD33481 wds:Q28611402-684BCFB2-B374-4491-A855-657823A91AB5 wds:Q28611402-6A19A978-E402-4EA1-A6E6-5DA6B8946345 wds:Q28611402-6BAA6C7D-8158-4126-B743-944B19D531E7 wds:Q28611402-779C0377-7422-4286-BB4B-0B345E3F0309 wds:Q28611402-7D2414EE-6AA4-4D43-8FBB-4EF54DA34D6E wds:Q28611402-86973BC6-C292-41B3-ABD8-CBB644C99105 wds:Q28611402-8ADFD276-0DE9-4E6F-AF82-E085FF2DCBB4 wds:Q28611402-8E14B458-058A-4F93-96DB-E572D20C81D0 wds:Q28611402-92F0DD8D-90D8-44A3-A47D-F615314FE951 wds:Q28611402-A6EF75E7-9F96-480C-9C04-47BDAE99E426 wds:Q28611402-AB5D71A6-9048-4618-8BAE-EEFBB0D557AB wds:Q28611402-AF7EF941-0A45-49B0-9888-1061D4275870 wds:Q28611402-B7D95B0B-0FA5-40D0-99C6-DFF49458B792 wds:Q28611402-B8639E9F-92F8-4AD3-9BF2-877F8568A193 wds:Q28611402-B97DE917-EA67-456C-88A4-EAA1DD36AE2C wds:Q28611402-BF7684A7-CBA0-4E5F-B886-791696423755 wds:Q28611402-C71D76C1-88AB-4773-8701-7B7A77D1E994 wds:Q28611402-CA5C42B5-BD1A-4E64-BA32-4B1BACB5C41B wds:Q28611402-CB9DF547-61BF-4777-ADC3-95DA0FA59230 wds:Q28611402-D2E21341-7046-480B-80F9-7F74545B0503 wds:Q28611402-D3E97A52-6F04-4365-944F-281BEE58C6E4 wds:Q28611402-D688A820-E995-4BB6-8EEA-43B561825A00 wds:Q28611402-DE23ABB9-6959-4EA0-876C-98755950D872 wds:Q28611402-DFFCC14A-B5BF-45A9-9D3B-F68422C8BECC wds:Q28611402-E3F36580-2555-490E-AF1B-E8E5E485811E wds:Q28611402-EAE8E261-9D87-4025-9D46-D2CCE50DA1F7 wds:Q28611402-F5DFB495-11DE-4A8B-9EEC-C62AB7381900
cites work	Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes A role for ATR in the DNA damage-induced phosphorylation of p53 Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms CHEK2 is a multiorgan cancer susceptibility gene Excess risk for contralateral breast cancer in CHEK21100delC germline mutation carriers. The CHEK21100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. A cancer family syndrome in twenty-four kindreds hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01 Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? Activated checkpoint kinase 2 provides a survival signal for tumor cells Germ-line alterations in MSR1 gene and prostate cancer risk Targeted cancer therapies based on the inhibition of DNA strand break repair Cdc25: mechanisms of checkpoint inhibition and recovery Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage Cellular responses to DNA damage: one signal, multiple choices The role of double-strand break repair — insights from human genetics Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: checkpoint activation as a strategy against cancer DNA repair inhibitors in cancer treatment. Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells Mutation analysis of the CHK2 gene in breast carcinoma and other cancers Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2 Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. G2 checkpoint abrogators as anticancer drugs The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1 CHEK2 mutations in primary glioblastomas. Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles CHEK2 I157T associates with familial and sporadic colorectal cancer CHEK2 variants predispose to benign, borderline and low-grade invasive ovarian tumors Alterations of Chk1 and Chk2 expression in colon cancer. Inhibitors of checkpoint kinases: from discovery to the clinic. Detecting, signalling and repairing DNA double-strand breaks.
author name string	wds:Q28611402-6CBDEF64-9AA5-40F5-B624-EDAED0C6614B wds:Q28611402-9F2D7BAC-033E-4D7E-8923-FC0C10789D86 wds:Q28611402-E6C38694-C5A2-4892-A899-B6004076672F wds:Q28611402-EA202D36-6A77-4245-9848-F64721EAE881
author name string	Rosario Perona Isabel Sánchez Pérez Rosario Machado-Pinilla

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