About: E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo

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About: E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo Goto Sponge NotDistinct Permalink

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description	artículu científicu espublizáu en 2000 (ast) vědecký článek publikovaný v roce 2000 (cs) 2000 թուականի Մայիսին հրատարակուած գիտական յօդուած (hyw) наукова стаття, опублікована в травні 2000 (uk) 2000 թվականի մայիսին հրատարակված գիտական հոդված (hy) vedecký článok (publikovaný 2000/05/01) (sk) مقالة علمية (نشرت في مايو 2000) (ar) wetenschappelijk artikel (gepubliceerd op 2000/05/01) (nl) scientific journal article (en) im Mai 2000 veröffentlichter wissenschaftlicher Artikel (de) মলিকুলার অ্যাণ্ড সেলুলার বায়োলজি নামক বৈজ্ঞানিক পত্রিকায় প্রকাশিত নিবন্ধ (bn)
publication date	wds:Q28585017-3653CB8F-45AE-4329-AC49-2AF7F04124DD
publication date	2000-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28585017-435697E8-0A2C-4333-BA53-52B32B0AA999
language of work or name	English
cites work	wds:Q28585017-0A93F90F-986A-46B4-A07F-8A5EE147CFE2 wds:Q28585017-0E7FD928-42E8-4E7E-AFEF-E9642BE8B681 wds:Q28585017-120667D1-21AB-40FA-8552-A1298046CD34 wds:Q28585017-16CEBCF5-B560-4C35-ACDB-B0B49CEF840F wds:Q28585017-18329AD1-72B5-40DE-8CBF-DA2C06EDD7EF wds:Q28585017-2C935D5C-0543-4CD2-9027-F1EA733A3990 wds:Q28585017-2E967EED-9A8C-4598-9661-6F0F979807B2 wds:Q28585017-334283E9-7844-43B6-99B8-F533B4CCF653 wds:Q28585017-374F458F-5A53-4890-A9C7-32B83E4762B9 wds:Q28585017-431D17B4-2810-44EF-91FA-C2F318DBCEF0 wds:Q28585017-4BAF40D3-7CA1-4A0B-A22E-D1A58534F12A wds:Q28585017-59B3CB18-FA0D-45D1-BBCA-D46588DA8597 wds:Q28585017-5F26DE0A-CBBC-4DA7-B713-104F2C8623ED wds:Q28585017-62CAAAF0-5565-4DFA-87FA-208862F20BFC wds:Q28585017-672FD600-DEDE-45BE-84C5-7CCD85F8AF73 wds:Q28585017-6D496991-641D-499A-8514-E3770961A810 wds:Q28585017-71E04134-7D77-4101-9F49-FFA70C302975 wds:Q28585017-81200B7C-C972-4D0D-B8A9-252E6674C156 wds:Q28585017-81A53A24-089D-4B61-B529-7B3D2C6DA99E wds:Q28585017-83AAECBA-BC9F-40E4-B818-B8E34CC62721 wds:Q28585017-91B0E591-BE21-4932-82EF-04657594A681 wds:Q28585017-9EC9CE78-A1FE-4545-AC8C-452D891DE4C3 wds:Q28585017-A0B41DEF-1B9E-4C49-B5D3-28C47A4E07FE wds:Q28585017-ACEC08FA-FE88-47B1-89D0-07C313BE7371 wds:Q28585017-B189F657-C0DB-4DA1-A922-A8413FA8FA3D wds:Q28585017-B6B06C5A-D91C-4EE2-8533-04754F1B30BB wds:Q28585017-C430CF20-84B8-4859-A27E-06F97B63A63D wds:Q28585017-C74A81A6-1B09-4D2D-A761-9115F4E8F985 wds:Q28585017-CD56AF0D-50C1-4B0F-98CA-B9BCED20FEDC wds:Q28585017-D3F6ECC4-2F6C-4AFA-BDD6-32DE0CA55BB2 wds:Q28585017-D646F7A6-E1A5-44FB-B857-6585C7E7674E wds:Q28585017-E2155A51-3F03-43C1-91B8-C3761825C00F wds:Q28585017-E3432A54-CA13-4C27-B5B8-5D1F529B4DE4 wds:Q28585017-F4D3C354-5751-4A02-8D60-9766E4E76FF9 wds:Q28585017-FA87C32A-203C-4D87-8B1E-4D947CFBE0E0 wds:Q28585017-FE531F9F-4032-44EE-90B7-1500A3B3159A
cites work	Cancer cell cycles A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry Differential activities of E2F family members: unique functions in regulating transcription Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members The regulation of E2F by pRB-family proteins Tumor surveillance via the ARF-p53 pathway. E2F activity is regulated by cell cycle-dependent changes in subcellular localization Induction of S-phase entry by E2F transcription factors depends on their nuclear localization Specific regulation of E2F family members by cyclin-dependent kinases E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 Distinct roles for E2F proteins in cell growth control and apoptosis E2F-4, a new member of the E2F transcription factor family, interacts with p107 E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest Nucleolar Arf sequesters Mdm2 and activates p53 The subcellular localization of E2F-4 is cell-cycle dependent An E2F-like repressor of transcription. Oncogenic capacity of the E2F1 gene Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites Mechanism of active transcriptional repression by the retinoblastoma protein Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53 p14ARF links the tumour suppressors RB and p53. E2F-6, a member of the E2F family that can behave as a transcriptional repressor Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53. Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development Toward an understanding of the functional complexity of the E2F and retinoblastoma families E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model Multiple members of the E2F transcription factor family are the products of oncogenes Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity Deregulated expression of cell-cycle proteins during premalignant progression in SENCAR mouse skin Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability
author name string	wds:Q28585017-295C365C-AF8B-4069-BC23-D84B70BC86FA wds:Q28585017-EE1D4B4D-2DD1-47C7-BEC0-8BBD8CD2A3D2
author name string	D Wang J L Russell
rdfs:label	E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo (en) E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo (nl) E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo (ast)
skos:prefLabel	E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo (en) E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo (nl) E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo (ast)
name	E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo (en) E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo (nl)

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