About: BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression

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About: BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression Goto Sponge NotDistinct Permalink

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scientific journal article

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description	artículu científicu espublizáu en 2003 (ast) vědecký článek publikovaný v roce 2003 (cs) 2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված (hy) наукова стаття, опублікована у вересні 2003 (uk) 2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած (hyw) wetenschappelijk artikel (gepubliceerd op 2003/09/05) (nl) vedecký článok (publikovaný 2003/09/05) (sk) مقالة علمية (نشرت في 5-9-2003) (ar) article publié dans la revue scientifique Journal of Biological Chemistry (fr) im September 2003 veröffentlichter wissenschaftlicher Artikel (de) scientific journal article (en)
publication date	wds:Q28570736-FEDEAEAE-08E7-4DA5-A45F-2037CC610211
publication date	2003-09-05 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28570736-6470D418-51A0-4A2E-A14A-2F35E2637652
language of work or name	English
cites work	wds:Q28570736-03DB42CA-DB54-44E7-9382-9CCEB57C6400 wds:Q28570736-05499151-0AFF-45E1-AB54-EA764D208CBD wds:Q28570736-0CCD9B77-9D8C-4935-BE93-4BBBB20867FE wds:Q28570736-1C6EDDEB-A6CF-4759-83CC-1AC5FEF276FD wds:Q28570736-1E33C3A8-2312-4CDD-BA7F-B3E3BA21EE41 wds:Q28570736-29766AB1-AB78-41E4-9E5C-DF2AD7C67547 wds:Q28570736-29D5F7CC-D433-49A8-A58E-45B9942A5CF1 wds:Q28570736-2F2B299C-E5AA-4B7A-8CBA-E295908A1C68 wds:Q28570736-323DC02E-A613-4DD5-80D3-1DF1B484B368 wds:Q28570736-3676F174-A515-41CF-907F-BBEBD99609CB wds:Q28570736-36A0F94C-32CE-453F-ACB7-DCC6B7F0E748 wds:Q28570736-3B304A5F-4233-4E0A-A165-D1E570A4A396 wds:Q28570736-41623D5D-ED29-407E-82C1-17008AA7274E wds:Q28570736-4C6F36AA-7B17-4F09-AEAD-A7A3EDA2D313 wds:Q28570736-4D093C00-B695-4741-81F4-1154FB9BF1A3 wds:Q28570736-53D96A6F-B8D4-4065-9207-8202F2A27B0E wds:Q28570736-6F5876E2-DFBD-43B9-B8A0-A573E8C68836 wds:Q28570736-71DFDD22-F3F3-46FC-89AD-9194F701DA54 wds:Q28570736-7990EFFF-39D8-472E-9892-BFE5660E593B wds:Q28570736-7CF60FDA-6515-47FB-9248-97D35DB41218 wds:Q28570736-939AFACA-88A8-4142-BE92-BE53F5D88CF9 wds:Q28570736-A2EA34C3-FBF9-4AE4-8ABA-ED172B09860D wds:Q28570736-AA9E2E3E-F092-4C30-9C67-2A8EFF4D140B wds:Q28570736-AF6A119D-DC92-4CFF-A2E0-4193A903CE9B wds:Q28570736-B3D0E79F-4560-4308-AE49-D9EF7056E15A wds:Q28570736-CBC07C7C-B2C1-432F-AA22-9497F4AC6CA0 wds:Q28570736-D969DF9E-2934-49F7-A003-CA21F48675AC wds:Q28570736-DBB2576B-BEDC-41E6-881E-4809180DE8C5 wds:Q28570736-E08200C2-52AF-4F77-A09F-42A1D845596E wds:Q28570736-E932C5BC-0906-46D7-A744-C67DA1CBA8F6 wds:Q28570736-F99E960F-7655-42FF-9D0D-6C0FB28C49DE wds:Q28570736-FF8167B2-1C4A-4923-897E-5151B54EEA79
cites work	A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts. Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation TGF-beta signalling from cell membrane to nucleus through SMAD proteins Cloning and characterization of two members of the vertebrate Dlx gene family The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2 Bone: formation by autoinduction Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta rDlx, a novel distal-less-like homeoprotein is expressed in developing cartilages and discrete neuronal tissues Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis. Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation Role of activator protein 1 transcriptional activity in the regulation of gene expression by transforming growth factor beta1 and bone morphogenetic protein 2 in ROS 17/2.8 osteoblast-like cells Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5 Hedgehog proteins stimulate chondrogenic cell differentiation and cartilage formation Early gene responses associated with transforming growth factor-beta 1 growth inhibition and autoinduction in MCF-7 breast adenocarcinoma cells Overexpression of Dlx5 in chicken calvarial cells accelerates osteoblastic differentiation
author name string	wds:Q28570736-447E6892-0610-4BD0-8EF3-F6D16F934BEB wds:Q28570736-532F83E5-7460-451B-92F7-3EF39BBB1ED4 wds:Q28570736-73122973-F205-42F5-94F7-4E7E90DC96D6 wds:Q28570736-8552C332-2396-4287-A34D-3A8C5647B13D wds:Q28570736-A0237245-4E4C-47A2-B453-876FB410B951 wds:Q28570736-A96811E8-D2D1-4609-B1A4-F5D566759836 wds:Q28570736-B599705F-FAD2-4DB6-82B6-61106D0E1B51 wds:Q28570736-C4CFDF55-249E-4814-9C26-DC4D0E379006 wds:Q28570736-D20CD6DB-F74B-4860-A344-876BF806CBA5 wds:Q28570736-EC9D4FE2-EBF2-4F23-AFF4-DAC7C51F53E8
OpenCitations bibliographic resource ID	wds:Q28570736-82BEE609-8D71-443A-984A-654CD9E9FDF4
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/3023133
author name string	Hyun-Jung Kim Hyun-Mo Ryoo Hee-Moon Kyung Mi-Hye Lee Youn-Jeong Kim John M. Wozney Jae-Hyun Sung Hyun-Dong Park

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