About: Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants

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About: Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants Goto Sponge NotDistinct Permalink

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description	article scientifique publié en 2006 (fr) artículu científicu espublizáu en 2006 (ast) vědecký článek publikovaný v roce 2006 (cs) наукова стаття, опублікована в липні 2006 (uk) 2006 թվականի հուլիսին հրատարակված գիտական հոդված (hy) 2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած (hyw) vedecký článok (publikovaný 2006/07/15) (sk) مقالة علمية (نشرت في 15-7-2006) (ar) wetenschappelijk artikel (gepubliceerd op 2006/07/15) (nl) scientific journal article (en) im Juli 2006 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q28513912-8F7B6D85-9374-4E40-ABED-089031194098
publication date	2006-07-15 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28513912-EEEEE131-97EE-40A6-86BD-D8F6D8EDCD36
language of work or name	English
cites work	wds:Q28513912-0BD2BC3E-8D5B-4F6A-9811-F6C08A8B0BB6 wds:Q28513912-1A61C4B6-0D91-4374-80AB-AF3A3974AB5B wds:Q28513912-1B719D91-B09D-4D21-B11B-8282B9E0C6B5 wds:Q28513912-1C5BFB2B-19B9-47B1-8D35-1F6C67ADAD04 wds:Q28513912-1DFD8F32-F997-459F-9195-EB7D193A8E2A wds:Q28513912-1F7AD25D-EC6B-419C-AB24-4C37831B6D10 wds:Q28513912-20DC251C-15F6-4D45-8B94-9120D119516A wds:Q28513912-22B2D3BE-B515-4DF5-BB5B-75EA4ADBC686 wds:Q28513912-2DCF25F7-919B-414B-AC80-519A60B8F392 wds:Q28513912-37B3970E-201C-4CB5-80D5-A6478241113C wds:Q28513912-3A97447F-C5FD-4C13-9CF3-C4A0EF55E3A9 wds:Q28513912-4757E131-9B57-4531-B8CC-C56BB80D508B wds:Q28513912-50BF93BF-DDF3-4E7A-BCE3-555F09BDC469 wds:Q28513912-5A1061B8-37B7-4389-B9B8-FB854426C43D wds:Q28513912-5EE1766B-647D-4262-9E7B-99A267C7C83A wds:Q28513912-6C431912-BD60-46B0-B657-5DFAAEAC8F54 wds:Q28513912-6E5A3B09-E3DF-49D2-8B35-AA8A6605AA2C wds:Q28513912-7A1EF5A4-9AD0-47F1-B041-C8AE4CE39C5A wds:Q28513912-7FBA9C4A-F48B-4DA7-8155-C724B8D2A555 wds:Q28513912-82AF6CFB-486D-4A0B-A8F1-2994DB9CF7D9 wds:Q28513912-8E9A828D-F68C-4DD3-BA65-12031D73DD63 wds:Q28513912-93941EE2-13A6-492D-829D-519935CE8BBB wds:Q28513912-96B4EB92-4AA2-49EB-8C48-59EEA52A8C43 wds:Q28513912-A90D8042-877A-4CE9-AF53-F24414D2A330 wds:Q28513912-AAFE4138-C7EE-4D3C-8307-1577806BE19C wds:Q28513912-C1C61E74-FFAF-4B6A-A2D8-2C9AAA8CFA80 wds:Q28513912-C98C1DD0-09FE-4286-984B-A589F497D4B6 wds:Q28513912-D1F07BEE-ABF8-49C1-B442-F2319E9A16DF wds:Q28513912-D7626E3E-19EE-4338-855E-70BBC348CEEE wds:Q28513912-DE7EF2B6-91DC-4641-8B3D-7574E06558AA wds:Q28513912-E2E2AA96-DB12-4608-ABB5-65C46C2FF926 wds:Q28513912-E5CF5D76-CC04-4502-A7C2-903D094EA187 wds:Q28513912-E61315D0-D0AB-4A2B-B070-10FE5B7885EA wds:Q28513912-E8DD1506-25A7-42B7-88DF-6A049A9843CA wds:Q28513912-EB3F058C-88DB-4E97-BEF2-BDF51546816A wds:Q28513912-F36023B6-9F67-4E27-9AEF-D28EEFB4D45D wds:Q28513912-F804B12A-566C-4CC5-92C4-922CEBAC1BF3
cites work	Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage TBX1 is required for inner ear morphogenesis Congenital heart disease in mice deficient for the DiGeorge syndrome region Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field. The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development Role of TBX1 in human del22q11.2 syndrome DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1 The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk Embryonic retinoic acid synthesis is essential for early mouse post-implantation development Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome A genetic link between Tbx1 and fibroblast growth factor signaling. Recovery from arterial growth delay reduces penetrance of cardiovascular defects in mice deleted for the DiGeorge syndrome region Patterning the pharyngeal arches Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function FGF-8 in the ventral pharynx alters development of myocardial calcium transients after neural crest ablation VEGF: a modifier of the del22q11 (DiGeorge) syndrome? Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.
author name string	wds:Q28513912-B1FC6D70-2887-4F48-8359-A53141D07055
OpenCitations bibliographic resource ID	wds:Q28513912-5B6D0AA3-A5B4-4C0C-961B-8C9619F2D54D
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/1343098
author name string	Angela Sobotka
OpenCitations bibliographic resource ID	1343098
rdfs:label	Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants (en) Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants (nl) Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants (ast)
skos:prefLabel	Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants (en) Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants (nl)

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