About: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia

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About: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia Goto Sponge NotDistinct Permalink

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scientific article (publication date: October 1997)

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rdf:type	Item
description	artículu científicu espublizáu en 1997 (ast) vědecký článek publikovaný v roce 1997 (cs) 1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած (hyw) 1997 թվականի հոտեմբերին հրատարակված գիտական հոդված (hy) наукова стаття, опублікована в жовтні 1997 (uk) مقالة علمية (نشرت في أكتوبر 1997) (ar) vedecký článok (publikovaný 1997/10/01) (sk) article scientifique publié en 1997 (fr) wetenschappelijk artikel (gepubliceerd op 1997/10/01) (nl) scientific article (publication date: October 1997) (en) im Oktober 1997 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q28250886-E8EFFFFC-056A-41DF-A0B8-E3597072A91D
publication date	1997-10-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28250886-D067D28F-9A56-4C9F-B17D-D6013034070A
language of work or name	English
author name string	wds:Q28250886-218FF6BC-2369-481C-B4DD-6293A4D49B35 wds:Q28250886-4D302B6D-7989-4F9E-AA51-0F5E87B5C614 wds:Q28250886-5E5EAA7B-E2D5-4627-BD33-8D9A7EFC2F0B wds:Q28250886-61D5E7F3-D6FA-4465-AD6B-E946356B5538 wds:Q28250886-64078F52-C971-4530-9D83-74AB84574AB4 wds:Q28250886-A1D4ECDB-ECBE-4582-913F-31A6BAB1D5C5 wds:Q28250886-A9E2D064-55D3-4D77-83D2-6935136324CD wds:Q28250886-B739B3A4-2BF4-4991-B61F-2F0B55203C7D wds:Q28250886-CB290CE3-BB2E-4572-9926-C150450D0D42 wds:Q28250886-F4418AA9-3422-4499-A565-2D5524603414 wds:Q28250886-FDFC103B-D470-4702-AD20-ECE694C2DA5F
author name string	P Marynen M Baens J Grosgeorge S D Raynaud H Van den Berghe I Wlodarska L Van Rompaey P Peeters J Cools P Philip F Monpoux
rdfs:label	Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (en) Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (nl) Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (ast)
skos:prefLabel	Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (en) Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (nl) Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (ast)
name	Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (en) Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (nl) Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (ast)
title	wds:Q28250886-2FB346D6-1420-4E5A-8CCD-AF9A6B650691
title	Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (en)
page(s)	wds:Q28250886-C8793452-605E-4542-872E-A943EF9A0F02
page(s)	2535-40
instance of	wds:Q28250886-52E0A3EA-AB27-4C29-9AE2-CB0B8C30EE6F
instance of	scholarly article
main subject	wds:Q28250886-4168217B-8B91-4C65-BA94-4C6033D6B751 wds:Q28250886-788DDF10-7A79-4460-AD81-173614E4C972
main subject	leukemia myeloid leukemia
PubMed ID	wds:Q28250886-F803A88B-E5EB-48BA-8B14-3A58A3BDF1ED
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9326218
PubMed ID	9326218
published in	wds:Q28250886-1C09F2AC-6391-4497-A029-7BB801EA7615
published in	Blood
issue	wds:Q28250886-F4DE5B13-8358-4632-A274-E96EB3DBF035
volume	wds:Q28250886-3C32A152-90EF-4884-8A60-8FB367FA17D7
issue	7
volume	90
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q28250886
is cites work of	Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3). Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase STAT signaling in the pathogenesis and treatment of cancer TYK2 is a key regulator of the surveillance of B lymphoid tumors Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components. ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5 JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia Canonical and non-canonical JAK-STAT signaling Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation Translocations in epithelial cancers The Janus kinases (Jaks) Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding protein. Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition CUL-4A is critical for early embryonic development Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia Lnk constrains myeloproliferative diseases in mice Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis The TEL/ARG leukemia oncogene promotes viability and hyperresponsiveness to hematopoietic growth factors Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.

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