About: A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation

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About: A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation Goto Sponge NotDistinct Permalink

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description	artículu científicu espublizáu en 2014 (ast) vědecký článek publikovaný v roce 2014 (cs) 2014 թվականի հունիսին հրատարակված գիտական հոդված (hy) наукова стаття, опублікована в червні 2014 (uk) 2014 թուականի Յունիսին հրատարակուած գիտական յօդուած (hyw) مقالة علمية (نشرت في يونيو 2014) (ar) vedecký článok (publikovaný 2014/06/01) (sk) wetenschappelijk artikel (gepubliceerd op 2014/06/01) (nl) article scientifique publié en 2014 (fr) scientific journal article (en) im Juni 2014 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q28116504-4CA62583-912D-48E2-9FFC-426FD5FF0AB6
publication date	2014-06-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28116504-3349AAF9-B27C-4F14-8E4E-5141998EDDE6
language of work or name	English
cites work	wds:Q28116504-06DAA599-FE73-478E-87DA-26FECE9A30BF wds:Q28116504-1501B176-3CA9-4912-8057-2A5D2BD7765D wds:Q28116504-19DF2A2B-EEAF-41B2-AB67-71FABF244DD8 wds:Q28116504-310C8499-E0BA-4080-AE0F-D30A142AE411 wds:Q28116504-3A48D2E0-1BA5-4DFC-A500-10527A6B2F53 wds:Q28116504-3BB93AF9-787D-4492-BB6F-C39ACC9E1782 wds:Q28116504-4E9DB320-3F80-41A3-9BF4-621C98F6ED0E wds:Q28116504-5415AE11-86D5-43BB-9237-3EFDE41E8CD6 wds:Q28116504-55526482-05A9-4378-A54F-DF06BD9EF2C1 wds:Q28116504-56711D17-856E-4251-A15B-81E9191F8D24 wds:Q28116504-572A6587-61BB-4853-99F0-838AF095CA5D wds:Q28116504-59337A63-9FF2-424C-8D51-66EA66884C1D wds:Q28116504-59D165AB-1B85-48BD-A1B0-14DB5864717F wds:Q28116504-65AF010E-4A03-4BDD-9F4C-1FA647953244 wds:Q28116504-69194708-B6E4-4A5A-817D-777A6732E32D wds:Q28116504-6D0FDD73-C58C-48B7-8434-555BE1EA685C wds:Q28116504-6DAC417C-BC90-40C4-9868-D8142825FEA9 wds:Q28116504-70CF242C-85DD-47B1-BEF2-BEE66F48BCCD wds:Q28116504-82B9EB5F-C992-4A97-8724-E057094F5971 wds:Q28116504-8750395B-AC7B-4CA6-A300-B661CC427459 wds:Q28116504-89E0DBC8-8E57-45AD-A0F0-4D6AC6CB3AA4 wds:Q28116504-99A77D02-03DA-406B-9414-05C506F6C27F wds:Q28116504-9BC55C27-44F2-4E14-885F-2C46309E523A wds:Q28116504-AC8F4BF7-3D34-4275-8563-2E3DF1E4F0AC wds:Q28116504-C3F88DFF-8E77-4775-BB35-B5969522A523 wds:Q28116504-C8E1F6F1-EF44-4F9C-9894-8D0084DB5A9D wds:Q28116504-D31F9EF7-AD50-4482-BAC1-B8E4313EE607 wds:Q28116504-DA5288B6-1B42-4698-BB43-F0E4FC2604E0 wds:Q28116504-E01B11D1-305E-43F8-BE32-25AC9370B7B1 wds:Q28116504-E043AD12-E71D-441B-A060-FD67A63284A0 wds:Q28116504-EBE9A82B-96DB-4025-AB2E-85ED1A078673
cites work	Efficient selection for high-expression transfectants with a novel eukaryotic vector Cation-chloride cotransporters and neuronal function Excitatory GABA action is essential for morphological maturation of cortical neurons in vivo Genic intolerance to functional variation and the interpretation of personal genomes Dendritic spine pathology in epilepsy: cause or consequence? Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2 Behavioural phenotypes of hypomorphic KCC2-deficient mice An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo Mechanisms of human inherited epilepsies A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport Genetic dissection of the common epilepsies A polygenic heterogeneity model for common epilepsies with complex genetics. GABA actions and ionic plasticity in epilepsy. Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene Decreased neuronal synchronization during experimental seizures. Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride Validation of a questionnaire for clinical seizure diagnosis Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila. KCC2 interacts with the dendritic cytoskeleton to promote spine development Role of the sodium channel SCN9A in genetic epilepsy with febrile seizures plus and Dravet syndrome. Molecular mechanisms of cognitive and behavioral comorbidities of epilepsy in children Augmented currents of an HCN2 variant in patients with febrile seizure syndromes Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission Synchronization and desynchronization in epilepsy: controversies and hypotheses
author name string	wds:Q28116504-4AA83C00-94DD-4B7A-A6D1-9708E6618FB0 wds:Q28116504-57907C31-080F-42C0-B8F7-C34AF1DEFCF7 wds:Q28116504-5CB202AC-245D-4496-8AE9-E44BEB518E8E wds:Q28116504-83AD3C6F-C25C-494D-8006-74C09B42AD02 wds:Q28116504-B30DF9E9-33C9-4E16-AD80-B71130F3F8D0 wds:Q28116504-CAC6CB90-F95C-4542-968C-DAA128A066D9 wds:Q28116504-ECFD5A8D-4D5D-4592-A331-41DE2434BFD7 wds:Q28116504-EF47C4A4-3D2B-43C5-B665-815205AAB9D1 wds:Q28116504-EFCC5831-9081-482D-B574-9290D24B65B6
OpenCitations bibliographic resource ID	wds:Q28116504-103AE0D3-3F6D-4AEB-AA80-45A9E8B41384
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/4314432
author name string	Peter Blaesse Bronwyn E. Grinton Faraz Ahmad Karen L. Oliver Laszlo Vutskits Patricia Seja Sarah E. Heron Tristiana C. Williams Xenia Iona
OpenCitations bibliographic resource ID	4314432
rdfs:label	A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation (en)

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