About: ubiquitin protein ligase activity

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Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an iso

Attributes	Values
rdf:type	Item
description	biologisch proces (nl) біологічний процес (uk) Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an iso (en)
exact match	wds:Q21095456-3D94A0BD-E6CA-4668-92DF-29E934516997
exact match	http://purl.obolibrary.org/obo/GO_0061630
rdfs:label	ubiquitin protein ligase activity (en)
skos:prefLabel	ubiquitin protein ligase activity (en)
name	ubiquitin protein ligase activity (en)
Gene Ontology ID	wds:Q21095456-34B1700D-BFCF-475F-9B6D-C9F7D57541F9 wds:Q21095456-7C65DC8B-0FC0-482E-8EFA-507CDC6C799F wds:Q21095456-84570672-05E4-4D33-94F6-09EA421FBC9B wds:Q21095456-8B6224F5-C8EF-4C23-A794-69617615C9B6 wds:Q21095456-DFDFC3AB-F199-45B8-9607-07C10B01ADE4
Gene Ontology ID	GO:0061630
instance of	wds:Q21095456-E6A8ADDC-BD30-41EB-BAAD-8B29BE4CBBDD
instance of	molecular function
subclass of	wds:Q21095456-0DD6B930-4C2F-4FF2-883F-086C59C2A118 wds:Q21095456-2ACAF9D0-59E9-4D68-B0D9-1177094D4849
subclass of	ubiquitin-protein transferase activity ubiquitin-like protein ligase activity
skos:altLabel	GO:0061630 (en) protein ubiquitination activity (en) ubiquitin ligase activity (en)
is owl:sameAs of	ubiquitin protein ligase activity ubiquitin protein ligase activity ubiquitin protein ligase activity ubiquitin protein ligase activity
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q21095456
is pr:P3452 of	wdref:97dfa6061add7818387f01925c1ff1c876dec62b
is subclass of of	ubiquitin-ubiquitin ligase activity histone ubiquitin ligase activity
is subclass of of	wds:Q112998306-425CF1D6-E382-40A1-8D78-82E3C02FE2F0 wds:Q21108473-4BF17177-4F7A-4A2F-B5E2-A2FA3E5B408E
is main subject of	A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro. Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses Interaction of the Salmonella Typhimurium effector protein SopB with host cell Cdc42 is involved in intracellular replication Forkhead box F2 suppresses gastric cancer through a novel FOXF2-IRF2BPL-β-catenin signaling axis. The ubiquitin-protein ligase Itch regulates p73 stability Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins Protein microarray characterization of the S-nitrosoproteome Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181 Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology TRIP12 functions as an E3 ubiquitin ligase of APP-BP1 The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5 E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1 Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1 Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP The HLA-DRalpha chain is modified by polyubiquitination Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. Trim24 targets endogenous p53 for degradation Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity. A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein A HECT domain E3 enzyme assembles novel polyubiquitin chains U box proteins as a new family of ubiquitin-protein ligases RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53 Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125 Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1 TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes Biochemical characterisation of the SWI/SNF family member HLTF. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase Dopamine covalently modifies and functionally inactivates parkin RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation SH3RF2 functions as an oncogene by mediating PAK4 protein stability The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair

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